It’s nicknamed the Eternal City for a reason. In Rome, you can drink from a street fountain fed by an ancient aqueduct. Or see the same profile on a statue in the Capitoline Museum and the guy making your cappuccino. (Which, of course, you know never to order after 11 am.) Rome is also a city of contrasts—what other place on earth could be home to both the Vatican and La Dolce Vita?

Located on the Rhine River near the borders of France and Germany, Basel contains the country's highest concentration of museums. The culture-centric city, site of the world's most influential art market each June, is also home to the lovely Munster Cathedral, made of red sandstone with a multi-colored tile roof. Green spaces abound, including the popular zoological gardens in the city center. Switzerland's largest site of Roman ruins, Augusta Raurica, are an easy day trip to the east.

While many visitors come for the beaches, arts celebrations and fiestas, San Sebastian-Donostia is serious about its food and drink. The Old Quarter’s narrow, winding streets are full of bars and restaurants, and in the modern city, sidewalk cafes are all around. The city specialises in seafood. Just make sure you know not to expect dinner at 6 or 7 p.m.—that’s much too early in Spain. Instead, tide yourself over with tapas, and enjoy eating and drinking late into the night.

Holland's most modern city began as a fishing village in the 13th century. It was developing into an industrial and trading power when German bombers destroyed the city centre and harbour in 1940. However, Rotterdam's unique architecture now brings many visitors to cycle around this urbane, cosmopolitan city. Old Dutch-style houses can still be found in historic Delfshaven, from where the pilgrims set sail in 1620. Cultural offerings ranging from the summer carnival to classical music can compete with those of Amsterdam.

Want to make your co-workers insanely jealous? Just casually drop "I’m holiday making in the Maldives this year" into conversation, preferably in the dead of winter. Or better yet, go there without mentioning it to anyone—then send them a "Wish you were here!" postcard.

Laid-back Ella draws travellers to Sri Lanka's highlands with its mountain forests, tea plantations, and relatively cool climate. The wildlife-rich region is also home to caves, cascades, and secluded temples—plus the Ella Gap, which offers lofty views between a cleft in two hills.

Ancient civilization gets a tropical beach twist in Mui Ne, a resort town in southeast Vietnam. Formidable Cham towers seem to keep watch over the visitors who come here for the epic kitesurfing or to frolic along the sand dunes. Candy-colored fishing vessels bob gently in the waters of Mui Ne Harbor, where you can buy steamed seafood that’s literally fresh off the boat.