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Profiling of testis-specific or testis-predominant genes expressed in mouse male germ cell lines GC-1 and GC-2
BackgroundSpermatogenesis is a tightly organized process that utilizes an intrinsic genetic program composed of germ cell-specific genes. Although...
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Multiple transcriptome analyses reveal mouse testis developmental dynamics
The testes are the organs of gamete production and testosterone synthesis. Up to date, no model system is available for mammalian testicular...
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Isolation and Characterization of Testis Macrophages Using Flow Cytometry
Testis-resident macrophages are first responders of the innate immune system against pathogens. They also exert day-to-day functions that are poorly...
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The Rete Testis: Development and Role in Testis Function
AbstractThe rete testis connects seminiferous tubules in which germ cells develop to the efferent ducts and the epididymis, where gametes mature and...
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High Concentration of Iron Ions Contributes to Ferroptosis-Mediated Testis Injury
In order to explore the effect of excessive iron supplementation on ferroptosis in mouse testes, Kunming mice received injections of varying...
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FGF-independent MEK1/2 signalling in the developing foetal testis is essential for male germline differentiation in mice
BackgroundDisrupted germline differentiation or compromised testis development can lead to subfertility or infertility and are strongly associated...
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The immunolocalization of adiponectin and its receptors in the testis of the frog Pelophylax bergeri
In all vertebrates, reproductive strategies are achieved by modulation of the neuroendocrine system in a similar manner and with minor variations...
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New approaches concerning the testis of Astyanax lacustris (Characidae): immunohistochemical studies
Astyanax lacustris , locally known as lambari-do-rabo-amarelo, is a study model for Neotropical fish. Testis of A. lacustris shows deep...
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Association between Yili goose sperm motility and expression profiles of mRNA and miRNA in testis
BackgroundThe study was conducted to find out the candidate microRNA (miRNA) and genes that associated with sperm motility of Yili goose through...
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Prenatal nicotine exposure leads to epigenetic alterations in peripheral nervous system signaling genes in the testis of the rat
BackgroundPrenatal nicotine exposure (PNE) has been documented to cause numerous deleterious effects on fetal development. However, the epigenetic...
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Live Imaging of the Drosophila Testis Stem Cell Niche
Live imaging of adult tissue stem cell niches provides key insights into the dynamic behavior of stem cells, their differentiating progeny, and their...
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The cancer-testis lncRNA LINC01977 promotes HCC progression by interacting with RBM39 to prevent Notch2 ubiquitination
Cancer-testis genes are involved in the occurrence and development of cancer, but the role of cancer-testis-associated lncRNAs (CT-lncRNAs) in...
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Isolation and In Vitro Culture of Germ Cells and Sertoli Cells from Human Fetal Testis
In the human fetal testis, fetal germ cells (FGCs) are progressively surrounded by supporting Sertoli cells inside seminiferous cords. During the...
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Quantitative proteomics and phosphoproteomics reveal insights into mechanisms of ocnus function in Drosophila testis development
BackgroundTestis is the only organ supporting sperm production and with the largest number of proteins and tissue-specific proteins in animals. In...
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Pancreatic lipase-related protein 2 is selectively expressed by peritubular myoid cells in the murine testis and sustains long-term spermatogenesis
Spermatogenesis is a complicated process of germ cell differentiation that occurs within the seminiferous tubule in the testis. Peritubular myoid...
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Elucidating the molecular mechanisms underlying the induction of autophagy by antidepressant-like substances in C57BL/6J mouse testis model upon LPS challenge
The treatment of depression with pharmaceuticals is associated with many adverse side effects, including male fertility problems. The precise...
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Utility of melatonin in mitigating ionizing radiation-induced testis injury through synergistic interdependence of its biological properties
BackgroundIonizing radiations (IR) have widespread useful applications in our daily life; however, they have unfavorable effects on reproductive...
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Autophagy regulates sex steroid hormone synthesis through lysosomal degradation of lipid droplets in human ovary and testis
Autophagy is an evolutionarily conserved process that aims to maintain the energy homeostasis of the cell by recycling long-lived proteins and...
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Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice
The Cancer/Testis Antigen (CTA) genes comprise a group of genes whose expression under physiological conditions is restricted to the testis but is...
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Spem2, a novel testis-enriched gene, is required for spermiogenesis and fertilization in mice
Spermiogenesis is considered to be crucial for the production of haploid spermatozoa with normal morphology, structure and function, but the...
