Advance articles
-
Accepted Manuscript
Research Article 9 July 2024
Relation between the Dantu blood group variant and bacteraemia in Kenyan children: a population-based case control study
Silvia N Kariuki and othersThe Journal of Infectious Diseases, jiae339, https://doi.org/10.1093/infdis/jiae339Published: 9 July 2024 Section: Major Article -
Editor's Choice
Corrected Proof
Research Article 8 July 2024
Sources of Human Immunodeficiency Virus Infections Among Men Who Have Sex With Men With a Migration Background: A Viral Phylogenetic Case Study in Amsterdam, The Netherlands
Alexandra Blenkinsop and othersThe Journal of Infectious Diseases, jiae267, https://doi.org/10.1093/infdis/jiae267Published: 8 July 2024 Section: Major Article -
Corrected Proof
Editorial 8 July 2024
Molnupiravir in Combination With Nirmatrelvir/Ritonavir: No Cause for Alarm
Daniel R KuritzkesThe Journal of Infectious Diseases, jiae214, https://doi.org/10.1093/infdis/jiae214Published: 8 July 2024 Section: Editorial -
Accepted Manuscript
Brief Report 8 July 2024
Severe West Nile virus and Sars-CoV-2 infections in a patient with thymoma and anti-type I IFN antibodies
Federica Barzaghi and othersThe Journal of Infectious Diseases, jiae321, https://doi.org/10.1093/infdis/jiae321Published: 8 July 2024 Section: Brief Report -
Editor's Choice
Corrected Proof
Brief Report 8 July 2024
Combined Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 Reduces Molnupiravir-Induced Mutagenicity and Prevents Selection for Nirmatrelvir/Ritonavir Resistance Mutations
Shuntai Zhou and othersThe Journal of Infectious Diseases, jiae213, https://doi.org/10.1093/infdis/jiae213Published: 8 July 2024 Section: Brief ReportIn a SARS-CoV-2 macaque model, we found that molnupiravir induced several nirmatrelvir resistance mutations at low abundance that were not further selected in combination therapy. Coadministration of nirmatrelvir/ritonavir lowered the magnitude of the mutagenetic effect of molnupiravir.
-
Accepted Manuscript
Research Article 5 July 2024
Phase 3 Study Assessing Lot-to-lot Consistency of RSVPreF3 Vaccine and its Immune Response, Safety, and Reactogenicity When Co-administered with FLU-D-QIV
Nnenna Chime and othersThe Journal of Infectious Diseases, jiae342, https://doi.org/10.1093/infdis/jiae342Published: 5 July 2024 Section: Major ArticleThis study demonstrated the lot-to-lot consistency of 3 lots of RSVPreF3 vaccine and highlighted that RSVPreF3 and FLU-D-QIV co-administration was immunogenically noninferior (for 3 of 4 constituent influenza strains evaluated) to the administration of FLU-D-QIV alone, and was well tolerated.
-
Accepted Manuscript
Research Article 5 July 2024
Trajectories of serum HBsAg during treatment and association with HBsAg loss in children with HBeAg-positive chronic hepatitis B: a latent class trajectory analysis
Zhenzhen Yao and othersThe Journal of Infectious Diseases, jiae349, https://doi.org/10.1093/infdis/jiae349Published: 5 July 2024 Section: Major Article -
Accepted Manuscript
Research Article 4 July 2024
Genomic epidemiology and evolution of rhinovirus in western Washington State, 2021-22
Stephanie Goya and othersThe Journal of Infectious Diseases, jiae347, https://doi.org/10.1093/infdis/jiae347Published: 4 July 2024 Section: Major ArticleHuman rhinovirus A-C species and their co-circulating genotypes show remarkable overall genetic diversity. Using the largest collection of newly sequenced rhinovirus genomes to date, we demonstrate extensive co-circulation of highly divergent clades within a genotype with highly constrained amino acid variability in the viral polyprotein.
-
Accepted Manuscript
Research Article 4 July 2024
A DNA Methylation Signature from Buccal Swabs to Identify Tuberculosis Infection
Lovisa Karlsson and othersThe Journal of Infectious Diseases, jiae333, https://doi.org/10.1093/infdis/jiae333Published: 4 July 2024 Section: Major Article -
Corrected Proof
Correction 3 July 2024
Correction to: Antibody Levels and Protection After Hepatitis B Vaccine: Results of a 30-Year Follow-up Study and Response to a Booster Dose
The Journal of Infectious Diseases, jiae336, https://doi.org/10.1093/infdis/jiae336Published: 3 July 2024 Section: Correction -
Accepted Manuscript
Research Article 2 July 2024
Do pregnant persons want influenza vaccines? Knowledge, attitudes, perceptions, and practices toward influenza vaccines in 8 low- and middle-income countries
Margaret McCarron and othersThe Journal of Infectious Diseases, jiae340, https://doi.org/10.1093/infdis/jiae340Published: 2 July 2024 Section: Major ArticleWe explored knowledge, attitudes, and practices of pregnant persons about seasonal influenza vaccines to inform actions to improve vaccine uptake among this priority population.
-
Corrected Proof
Correction 2 July 2024
Correction to: Comparative Analysis of Ebola Virus Glycoprotein Interactions With Human and Bat Cells
The Journal of Infectious Diseases, jiae337, https://doi.org/10.1093/infdis/jiae337Published: 2 July 2024 Section: Correction -
Accepted Manuscript
Letter 1 July 2024
Response to Building the Future of Infectious Diseases: A Call to Action for Quality Improvement Research and Measurement
Caitlin Naureckas Li and othersThe Journal of Infectious Diseases, jiae338, https://doi.org/10.1093/infdis/jiae338Published: 1 July 2024 Section: Letter to the Editor -
Corrected Proof
Correction 1 July 2024
Correction to: Progress in Access and Oral Polio Vaccine Coverage Among Children Aged <5 Years in Polio Campaigns After the Political Change in Afghanistan
The Journal of Infectious Diseases, jiae334, https://doi.org/10.1093/infdis/jiae334Published: 1 July 2024 Section: Correction -
Accepted Manuscript
Research Article 29 June 2024
Results of a nationally representative seroprevalence survey of chikungunya virus in Bangladesh
Sam W Allen and othersThe Journal of Infectious Diseases, jiae335, https://doi.org/10.1093/infdis/jiae335Published: 29 June 2024 Section: Major ArticleWe use a nationally representative seroprevalence study to estimate the underlying burden to chikungunya prior to a major outbreak in 2017. We found the population had very limited immunity at the time but the vector was widespread.
-
Accepted Manuscript
Research Article 29 June 2024
Antibodies to Helminth Defense Molecule-1 are associated with inflammation, organomegaly, and decreased nutritional status in schistosomiasis japonica
Amanda E Ruiz and othersThe Journal of Infectious Diseases, jiae330, https://doi.org/10.1093/infdis/jiae330Published: 29 June 2024 Section: Major ArticleAntibodies targeting the immunomodulator Schistosoma japonicum Helminth Defense Molecule (SjHDM-1) are associated with increased inflammation, hepatomegaly and multiple measures of reduced nutritional status. Our results suggest that anti-SjHDM-1 responses inhibit the beneficial immunomodulatory function of SjHDM-1, resulting in host morbidity.
-
Editor's Choice
Accepted Manuscript
Research Article 28 June 2024
Risk factors for recurrent urinary tract infections among women in a large integrated health care organization in the United States
Bradley K Ackerson and othersThe Journal of Infectious Diseases, jiae331, https://doi.org/10.1093/infdis/jiae331Published: 28 June 2024 Section: Major Article -
Accepted Manuscript
Research Article 28 June 2024
Relative contributions of the novel diarylquinoline TBAJ-876 and its active metabolite to the bactericidal activity in a murine model of tuberculosis
Saskia E Mudde and othersThe Journal of Infectious Diseases, jiae332, https://doi.org/10.1093/infdis/jiae332Published: 28 June 2024 Section: Major ArticleThe profound bactericidal activity of the new diarylquinoline TBAJ-876 in a tuberculosis mouse model was substantially attributable to in vivo formation of the highly active M3-metabolite, highlighting the need to consider metabolites when translating mouse model findings to humans.
-
Accepted Manuscript
Research Article 27 June 2024
Safety and Immunogenicity of mRNA-1010, an Investigational Seasonal Influenza Vaccine, in Healthy Adults: Final Results From a Phase 1/2 Randomized Trial
Jintanat Ananworanich and othersThe Journal of Infectious Diseases, jiae329, https://doi.org/10.1093/infdis/jiae329Published: 27 June 2024 Section: Major ArticleA single dose of mRNA-1010 quadrivalent seasonal influenza vaccine elicited broad and durable humoral responses that persisted through 6 months as well as robust T-cell responses, with a safety profile consistent with other mRNA-based vaccines
-
Corrected Proof
Editorial 27 June 2024
T-Cell Responses to Treponema pallidum Proteins in Blood and Skin to Advance Syphilis Vaccine Design: Learning From Nature
Juan C Salazar and Justin D RadolfThe Journal of Infectious Diseases, jiae246, https://doi.org/10.1093/infdis/jiae246Published: 27 June 2024 Section: Editorial Commentary -
Corrected Proof
Research Article 27 June 2024
Treponema pallidum Periplasmic and Membrane Proteins Are Recognized by Circulating and Skin CD4+ T Cells
Tara B Reid and othersThe Journal of Infectious Diseases, jiae245, https://doi.org/10.1093/infdis/jiae245Published: 27 June 2024 Section: Major ArticleLittle is known about the targets of effector T cells during human syphilis. Herein we show that Treponema pallidum infection elicits antigen-specific CD4+ T-cell responses in blood and skin that persist in both compartments long after curative therapy.
-
Accepted Manuscript
Review Article 27 June 2024
Incidence of RSV in Adults: A Comprehensive Review of Observational Studies and Critical Gaps in Information
Benjamin Doty and othersThe Journal of Infectious Diseases, jiae314, https://doi.org/10.1093/infdis/jiae314Published: 27 June 2024 Section: ReviewWe conducted a global comprehensive literature review of studies reporting RSV incidence in adults. Estimates of RSV-incidence are variable; population-based studies with well-defined case definitions/surveillance strategies are needed in addition to studies in community-based populations and lower- and middle-income regions.
-
Accepted Manuscript
Research Article 25 June 2024
Precision symptom phenotyping identifies early clinical and proteomic predictors of distinct COVID-19 sequelae
Nusrat J Epsi and othersThe Journal of Infectious Diseases, jiae318, https://doi.org/10.1093/infdis/jiae318Published: 25 June 2024 Section: Major Article -
Corrected Proof
Editorial 25 June 2024
Prospectively Defined Clusters of Coronavirus Disease 2019 Sequelae
Shritha Velaga and Justin StebbingThe Journal of Infectious Diseases, jiae319, https://doi.org/10.1093/infdis/jiae319Published: 25 June 2024 Section: Editorial -
Accepted Manuscript
Research Article 24 June 2024
Inconsistent increase in age at RSV hospitalisation of children <2 years during the SARS-CoV-2 pandemic: a retrospective multicentre study in four European countries
Eline R Harding and othersThe Journal of Infectious Diseases, jiae292, https://doi.org/10.1093/infdis/jiae292Published: 24 June 2024 Section: Major ArticleDuring the SARS-CoV-2 pandemic RSV hospitalization patterns in children <2 year changed. Although a shift to older age was seen in the Netherlands, we did not observe an increase in age in the other three participating countries in Europe.
-
Corrected Proof
Research Article 24 June 2024
Osteopontin Depletion in Nonhematopoietic Cells Improves Outcomes in Septic Mice by Enhancing Antimicrobial Peptide Production
Chang Yu and othersThe Journal of Infectious Diseases, jiae320, https://doi.org/10.1093/infdis/jiae320Published: 24 June 2024 Section: Major ArticleOpn depletion in nonhematopoietic cells but not hematopoietic cells contributes to improved sepsis outcomes. Knockdown of Opn effectively reduced bacterial loads in the gut by increasing the expression of antimicrobial peptides through the AKT-FOXO3a signaling pathway.
-
Corrected Proof
Editorial 24 June 2024
New Publishing Strategy at JID
Cynthia L SearsThe Journal of Infectious Diseases, jiae326, https://doi.org/10.1093/infdis/jiae326Published: 24 June 2024 Section: Editorial Commentary -
Accepted Manuscript
Research Article 24 June 2024
The contrasting phenotypes of neutrophils during asymptomatic versus symptomatic Leishmania braziliensis infection
Jacilara A Conceiҫão and othersThe Journal of Infectious Diseases, jiae317, https://doi.org/10.1093/infdis/jiae317Published: 24 June 2024 Section: Major Article -
Accepted Manuscript
Editorial 24 June 2024
Hepatitis B surface antigen loss: what does integration have to do with a functional HBV cure?
Ashwin Balagopal and Chloe L ThioThe Journal of Infectious Diseases, jiae327, https://doi.org/10.1093/infdis/jiae327Published: 24 June 2024 Section: Viewpoint -
Accepted Manuscript
Research Article 20 June 2024
Post-mortem analysis of dolutegravir, tenofovir, lamivudine and efavirenz penetration in multiple CNS compartments
Fan Wang and othersThe Journal of Infectious Diseases, jiae325, https://doi.org/10.1093/infdis/jiae325Published: 20 June 2024 Section: Major ArticlePostmortem analysis of CNS tissues reveals heterogenous antiretroviral distribution.
-
Corrected Proof
Research Article 18 June 2024
Quantity and Quality of Naturally Acquired Antibody Immunity to the Pneumococcal Proteome Throughout Life
Marloes Vissers and othersThe Journal of Infectious Diseases, jiae255, https://doi.org/10.1093/infdis/jiae255Published: 18 June 2024 Section: Major Article -
Accepted Manuscript
Research Article 18 June 2024
Humoral Immunogenicity of mRNA-1345 RSV Vaccine in Older Adults
Jaya Goswami and othersThe Journal of Infectious Diseases, jiae316, https://doi.org/10.1093/infdis/jiae316Published: 18 June 2024 Section: Major ArticlemRNA-1345 vaccine enhanced levels of RSV-A and RSV-B nAb and preF bAb compared with placebo in adults (≥60 years) across various subgroups, including those at risk for severe disease, consistent with its demonstrated efficacy in the prevention of RSV disease.
-
Corrected Proof
Research Article 17 June 2024
Clinical Presentation of Early Syphilis and Genomic Sequences of Treponema pallidum Strains in Patient Specimens and Isolates Obtained by Rabbit Inoculation
Ligang Yang and othersThe Journal of Infectious Diseases, jiae322, https://doi.org/10.1093/infdis/jiae322Published: 17 June 2024 Section: Major ArticleWe collected specimens from individuals with early syphilis in Guangzhou, China, for Treponema pallidum quantitative polymerase chain reaction, whole genome sequencing (WGS), and isolation of T pallidum in rabbits. Our results support the use of WGS from rabbit isolates to inform vaccine development.
-
Corrected Proof
Research Article 17 June 2024
Breath Biomarkers of Pediatric Malaria: Reproducibility and Response to Antimalarial Therapy
Amalia Z Berna and othersThe Journal of Infectious Diseases, jiae323, https://doi.org/10.1093/infdis/jiae323Published: 17 June 2024 Section: Major ArticleThis validation study supports the hypothesis that Plasmodium falciparum malaria infection causes changes in breath composition. Specific breath volatiles are associated with low and high parasitemia, indicating that compound levels are dependent on parasitological features of malaria.
-
Corrected Proof
Brief Report 15 June 2024
Prevalence of Cefixime-Resistant Neisseria gonorrhoeae in Melbourne, Australia, 2021–2022
Eric P F Chow and othersThe Journal of Infectious Diseases, jiae313, https://doi.org/10.1093/infdis/jiae313Published: 15 June 2024 Section: Brief ReportThe prevalence of cefixime-resistant Neisseria gonorrhoeae among sexually active individuals in Melbourne exceeds the threshold of the 5% resistance level recommended by the World Health Organization. Thus, cefixime treatment would have limited benefits in Australia.
-
Corrected Proof
Research Article 15 June 2024
Dolutegravir- Versus Efavirenz-Based Treatment in Pregnancy: Impact on Red Blood Cell Folate Concentrations in Pregnant Women and Their Infants
Denise L Jacobson and othersThe Journal of Infectious Diseases, jiae308, https://doi.org/10.1093/infdis/jiae308Published: 15 June 2024 Section: Major ArticleOur findings from the randomized controlled clinical trial IMPAACT 2010/VESTED suggest that cellular uptake of folate and transport of folate to the infant do not differ in pregnant women starting dolutegravir- versus efavirenz-based antiretroviral therapy (nor tenofovir alafenamide vs tenofovir disoproxil fumarate).
-
Corrected Proof
Research Article 14 June 2024
Plasma From Older Children in Malawi Inhibits Plasmodium falciparum Binding in 3-Dimensional Brain Microvessels
Fatou Joof and othersThe Journal of Infectious Diseases, jiae315, https://doi.org/10.1093/infdis/jiae315Published: 14 June 2024 Section: Major ArticleIn highly endemic Plasmodium falciparum regions, older children acquire immunity that protects against severe malaria. This study used 3-dimensional human brain microvessels to demonstrate that older Malawian children acquire adhesion-blocking antibodies that may contribute to cerebral malaria immunity.
-
Corrected Proof
Research Article 14 June 2024
Varied Prevalence of Antimalarial Drug Resistance Markers in Different Populations of Newly Arrived Refugees in Uganda
Stephen Tukwasibwe and othersThe Journal of Infectious Diseases, jiae288, https://doi.org/10.1093/infdis/jiae288Published: 14 June 2024 Section: Major ArticleUgandan refugees newly arrived from South Sudan and the Democratic Republic of Congo were frequently infected with malaria parasites, with prevalences of markers of drug resistance remarkably different depending on the refugee country of origin.
-
Corrected Proof
Research Article 13 June 2024
Whole-Genome Sequencing of Invasive Neonatal Escherichia coli From Uppsala County, Sweden
Anna Heydecke and othersThe Journal of Infectious Diseases, jiae309, https://doi.org/10.1093/infdis/jiae309Published: 13 June 2024 Section: Major Article -
Corrected Proof
Obituary 12 June 2024
In Memoriam: W. Michael Scheld, MD
Allan R Tunkel and Bennett LorberThe Journal of Infectious Diseases, jiae290, https://doi.org/10.1093/infdis/jiae290Published: 12 June 2024 Section: Epilogue Reflections -
Accepted Manuscript
Research Article 12 June 2024
miRNome profiling of extracellular vesicles in severe COVID-19 patients and identification of predictors of mortality
Laura Sánchez-De Prada and othersThe Journal of Infectious Diseases, jiae310, https://doi.org/10.1093/infdis/jiae310Published: 12 June 2024 Section: Major Articleextracellular vesicles (EVs) contain microRNAs (miRNAs) that play a central role in intercellular communication. We massively analysed the miRNA profile in plasma-derived EVs from severe COVID-19 patients referred to controls, identifying two miRNAs (hsa-miR-1469 and hsa-miR-6124) as strong mortality predictors.
-
Corrected Proof
Research Article 12 June 2024
Establishing Correlates of Maternal-Fetal Cytomegalovirus Transmission—One Step Closer Through Predictive Modeling
Arnaud Marchant and othersThe Journal of Infectious Diseases, jiae281, https://doi.org/10.1093/infdis/jiae281Published: 12 June 2024 Section: Major ArticleUsing different models (participant clustering/stratification and an interpretable predictive model using trained decision trees for risk prediction), we found that anti-pentamer IgG concentration during pregnancy and viral load in saliva are biomarkers jointly predicting the risk of maternal-fetal cytomegalovirus transmission.
-
Corrected Proof
Brief Report 12 June 2024
Correlation of Genogroup I, Genotype 1 (GI.1) Norovirus Neutralizing Antibody Levels With GI.1 Histo-Blood Group Antigen–Blocking Antibody Levels
Robert L Atmar and othersThe Journal of Infectious Diseases, jiae311, https://doi.org/10.1093/infdis/jiae311Published: 12 June 2024 Section: Brief ReportGI.1 norovirus antibody levels measured by microneutralization assay are highly correlated with those measured by histo-blood group antigen–blocking assays.
-
Corrected Proof
Research Article 10 June 2024
Safety and Immunogenicity of a 4-Component Generalized Modules for Membrane Antigens Shigella Vaccine in Healthy European Adults: Randomized, Phase 1/2 Study
Isabel Leroux-Roels and othersThe Journal of Infectious Diseases, jiae273, https://doi.org/10.1093/infdis/jiae273Published: 10 June 2024 Section: Major Article -
Accepted Manuscript
Research Article 10 June 2024
Cytomegalovirus antiviral resistance among participants in the phase 3 trial of letermovir vs valganciclovir prophylaxis in kidney transplant recipients
Julie M Strizki and othersThe Journal of Infectious Diseases, jiae287, https://doi.org/10.1093/infdis/jiae287Published: 10 June 2024 Section: Major ArticleAmong 589 CMV D+R- kidney transplant recipients who received CMV disease prophylaxis with letermovir or valganciclovir for up to 200 days, there was a low risk for development of resistance to letermovir.
-
Corrected Proof
Research Article 7 June 2024
Antibody and T-Cell Response to Bivalent Booster SARS-CoV-2 Vaccines in People With Compromised Immune Function: COVERALL-3 Study
Alain Amstutz and othersThe Journal of Infectious Diseases, jiae291, https://doi.org/10.1093/infdis/jiae291Published: 7 June 2024 Section: Major ArticleKidney transplant recipients and people with HIV had a robust cellular and humoral response after receiving bivalent SARS-CoV-2 vaccines, lasting for 6 months, and adverse events were rare. Lung transplant recipients mounted a delayed and insufficient immune response.
-
Corrected Proof
Research Article 7 June 2024
B-Cell Activation Gene Signature in Blood and Liver of Hepatitis B e Antigen–Positive Patients With Immune Active Chronic Hepatitis B
Zgjim Osmani and othersThe Journal of Infectious Diseases, jiae280, https://doi.org/10.1093/infdis/jiae280Published: 7 June 2024 Section: Major Article -
Corrected Proof
Research Article 6 June 2024
Nipah Virus-Associated Neuropathology in African Green Monkeys During Acute Disease and Convalescence
Kerry Goldin and othersThe Journal of Infectious Diseases, jiae300, https://doi.org/10.1093/infdis/jiae300Published: 6 June 2024 Section: Major ArticleThis is an in-depth study into the spectrum and distribution of CNS lesions in African green monkeys infected with Nipah virus. CNS lesions during the acute and convalescent stage were investigated, providing valuable insight into Nipah virus meningoencephalitis.
-
Corrected Proof
Research Article 6 June 2024
Impact of Hypoxia-Inducible Factor-1α on Host Immune Metabolism and Tissue Damage During Mycobacterium bovis Infection
Yue Nan and othersThe Journal of Infectious Diseases, jiae305, https://doi.org/10.1093/infdis/jiae305Published: 6 June 2024 Section: Major ArticleThis article investigates the potential relationship between HIF-1α, host immune metabolism, and tissue damage during Mycobacterium bovis infection, aiming to offer pertinent insights for host-directed therapy.
-
Corrected Proof
Brief Report 6 June 2024
Recurrent Group B Streptococcus Neonatal Invasive Infections, France, 2007–2021
Ghalia Sbaa and othersThe Journal of Infectious Diseases, jiae307, https://doi.org/10.1093/infdis/jiae307Published: 6 June 2024 Section: Brief ReportGroup B Streptococcus (GBS) neonatal infections recur in approximately 2% of cases. Prematurity, low birth weight, and GBS clonal complex 17 are largely associated with recurrence. Isolates from both episodes are fully susceptible to β-lactams and most often strictly identical.
-
Corrected Proof
Research Article 6 June 2024
Dysregulation of Stress Erythropoiesis and Enhanced Susceptibility to Salmonella Typhimurium Infection in Aryl Hydrocarbon Receptor–Deficient Mice
Michelle Mayer and othersThe Journal of Infectious Diseases, jiae304, https://doi.org/10.1093/infdis/jiae304Published: 6 June 2024 Section: Major ArticleAryl hydrocarbon receptor deficiency in mice results in increased susceptibility to chronic systemic Salmonella infection due to enhanced erythropoietin-driven stress erythropoiesis in the spleen and accompanying destruction of the splenic architecture.
-
Corrected Proof
Research Article 6 June 2024
Dengue NS1 Antibodies Are Associated With Clearance of Viral Nonstructural Protein-1
Michelle Premazzi Papa and othersThe Journal of Infectious Diseases, jiae299, https://doi.org/10.1093/infdis/jiae299Published: 6 June 2024 Section: Major ArticleSecondary infections of dengue virus were characterized by higher NS1 antibodies. There was a negative correlation between NS1 antibody and protein during the course of infection with antigen-antibody complexes cleared after the febrile phase.
-
Corrected Proof
Research Article 6 June 2024
A Robust Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)–Specific T- and B-Cell Response Is Associated With Early Viral Clearance in SARS-CoV-2 Omicron-Infected Immunocompromised Individuals
Magda Vergouwe and othersThe Journal of Infectious Diseases, jiae306, https://doi.org/10.1093/infdis/jiae306Published: 6 June 2024 Section: Major ArticleIn Omicron-infected immunocompromised patients, early and strong T- and B-cell responses are associated with effective viral clearance and fewer emergences of monoclonal antibody resistance-associated mutations. This highlights the importance of early immune responses, supporting the development of novel therapeutic approaches.
-
Corrected Proof
Research Article 5 June 2024
Cytokine Biomarkers of Exacerbations in Sputum From Patients With Chronic Obstructive Pulmonary Disease: A Prospective Cohort Study
Sonia Budroni and othersThe Journal of Infectious Diseases, jiae232, https://doi.org/10.1093/infdis/jiae232Published: 5 June 2024 Section: Major ArticleMeasuring 30 cytokines in 936 sputum samples from patients with chronic obstructive pulmonary disease, we observed significant increases (IL-17A, TNF-α, IL-1β, IL-10) between stable and exacerbation states. We also identified a combination of cytokines (IL-1α, IL-1β, or TNF-α) as suitable biomarkers for bacteria-associated exacerbations.
-
Accepted Manuscript
Research Article 5 June 2024
Seroepidemiology of measles and rubella among Hong Kong young adults and the humoral responses of an MMR booster among participants with low antibody levels
Jeffery C H Chan and othersThe Journal of Infectious Diseases, jiae297, https://doi.org/10.1093/infdis/jiae297Published: 5 June 2024 Section: Major ArticleYoung adults in Hong Kong had failure rates of 5.3% and 2.7% to measles and rubella vaccines, respectively. One month after an MMR booster, antibody levels against measles and rubella increased significantly, even for participants who had vaccine failures.
-
Corrected Proof
Research Article 5 June 2024
Kinetics and Durability of Antibody and T-Cell Responses to SARS-CoV-2 in Children
Megan A Files and othersThe Journal of Infectious Diseases, jiae301, https://doi.org/10.1093/infdis/jiae301Published: 5 June 2024 Section: Major ArticleChildren represent an understudied, yet vulnerable population to COVID-19 infection. We found that S-specific humoral and cell-mediated responses were robust and durable over time, in contrast to a relatively short-lived immunity to N.
-
Corrected Proof
Research Article 5 June 2024
Pharmacokinetics and Safety of Remdesivir in Pregnant and Nonpregnant Women With COVID-19: Results From IMPAACT 2032
Kristina M Brooks and othersThe Journal of Infectious Diseases, jiae298, https://doi.org/10.1093/infdis/jiae298Published: 5 June 2024 Section: Major ArticleThe plasma PK of remdesivir and its major metabolites were comparable between hospitalized pregnant and nonpregnant women with COVID-19, suggesting no dose adjustments are needed for intravenous remdesivir in pregnancy.
-
Editor's Choice
Corrected Proof
Research Article 31 May 2024
Outcomes of SARS-CoV-2 and Seasonal Viruses Among 2 Million Adults Hospitalized for Severe Acute Respiratory Infection During the COVID-19 Pandemic in Brazil
Lilian M Diniz and othersThe Journal of Infectious Diseases, jiae295, https://doi.org/10.1093/infdis/jiae295Published: 31 May 2024 Section: Major ArticleThis population-based study analyzed the outcomes of hospitalized patients with severe acute respiratory infections. The study found that patients with SARS-CoV-2 and adenovirus had twice the risk of death as those with seasonal viruses, after controlling for potential confounding factors.
-
Accepted Manuscript
Review Article 31 May 2024
Urgent Need to Understand and Prevent Gonococcal Infection: From the Laboratory to Real-World Context
Yara Ruiz García and othersThe Journal of Infectious Diseases, jiae289, https://doi.org/10.1093/infdis/jiae289Published: 31 May 2024 Section: ReviewGonorrhea is increasing in incidence globally; however, there is no vaccine available. This manuscript provides a description of the response of the immune system against gonococcal infections and potential vaccine mechanism of action to inform research and policy decisions.
-
Corrected Proof
Brief Report 31 May 2024
Impact of Variable Sampling on Estimates of HIV-1 Reservoir Formation Dates
Edward N Kankaka and othersThe Journal of Infectious Diseases, jiae294, https://doi.org/10.1093/infdis/jiae294Published: 31 May 2024 Section: Brief ReportWe explored methodological sources of variability in the dating of HIV-1 reservoir formation, and show that faster-evolving genes can cause significant shifts in formation date distributions, while timing, frequency, and depth of sampling had little effect on estimates.
-
Corrected Proof
Research Article 31 May 2024
Household Transmission and Clinical Features of Respiratory Tract Infections That Were SARS-CoV-2 Positive and Negative
Jaakko Ahti and othersThe Journal of Infectious Diseases, jiae278, https://doi.org/10.1093/infdis/jiae278Published: 31 May 2024 Section: Major ArticleIn a Finnish cohort, household transmission of SARS-CoV-2 infections was higher when compared with SARS-CoV-2–negative respiratory infections. SARS-CoV-2 transmission was similar for adult and child index cases, whereas the transmission of SARS-CoV-2–negative infections was higher for child index cases.
-
Corrected Proof
Research Article 31 May 2024
Drug Resistance and Epidemiological Success of Modern Mycobacterium tuberculosis Lineages in Western India
Avika Dixit and othersThe Journal of Infectious Diseases, jiae240, https://doi.org/10.1093/infdis/jiae240Published: 31 May 2024 Section: Major ArticleUsing whole-genome sequencing of Mycobacterium tuberculosis clinical isolates in two prospective cohort studies of pulmonary tuberculosis in Pune, we identified lineage 2 and lineage 4 isolates to have higher epidemiological success and lineage 2 to have higher drug resistance rates than lineages 1 and 3.
-
Corrected Proof
Brief Report 31 May 2024
Effect of Smoking on Longitudinal Interferon γ Release Assay Results Among Close Contacts of People with Pulmonary Tuberculosis
María B Arriaga and othersThe Journal of Infectious Diseases, jiae285, https://doi.org/10.1093/infdis/jiae285Published: 31 May 2024 Section: Brief ReportSmoking among close contacts of people with tuberculosis was associated with lower odds of IGRA reversion. Our findings highlight the importance of smoking on longitudinal IGRA results and clinical research in which IGRA status is used as an outcome.
-
Corrected Proof
Research Article 31 May 2024
Serum Immunoglobulin G Antibodies to Human Papillomavirus Type 6 L1, E2, E4, E6, and E7 Proteins Among Children Prospectively Followed up for 3 Years
Helmi Suominen and othersThe Journal of Infectious Diseases, jiae293, https://doi.org/10.1093/infdis/jiae293Published: 31 May 2024 Section: Major ArticleMaternal antibodies against human papillomavirus type 6 (HPV-6) early and late proteins are transferred to their offspring, and our results demonstrate that seroconversion to HPV-6 L1, E2, E4, E6, and E7 does occur in early childhood.
-
Editor's Choice
Corrected Proof
Editorial 30 May 2024
Why is Parasite Sex Sexy?
Sebastian Shaw and Boris StriepenThe Journal of Infectious Diseases, jiae277, https://doi.org/10.1093/infdis/jiae277Published: 30 May 2024 Section: Viewpoint -
Corrected Proof
Research Article 29 May 2024
Nasal and Pharyngeal Mucosal Immunity to Poliovirus in Children Following Routine Immunization With Inactivated Polio Vaccine in the United States
Audrey Godin and othersThe Journal of Infectious Diseases, jiae264, https://doi.org/10.1093/infdis/jiae264Published: 29 May 2024 Section: Major ArticleThis study provides policy-relevant evidence that children routinely immunized with inactivated polio vaccine in the United States and who had no known contact with a live poliovirus had detectable nasal and pharyngeal mucosal immunity to poliovirus.
-
Corrected Proof
Research Article 28 May 2024
Staphylococcus aureus Conquers Host by Hijacking Mitochondria via PFKFB3 in Epithelial Cells
Xing Gao and othersThe Journal of Infectious Diseases, jiae263, https://doi.org/10.1093/infdis/jiae263Published: 28 May 2024 Section: Major ArticleStaphylococcus aureus induced sirtuin 3 degradation via mitophagy, thereby shifting metabolism toward glycolysis. Inhibition of PFKFB3 reduced mitochondrial damage by limiting reactive oxygen species production and alleviated the degradation of sirtuin 3.
-
Corrected Proof
Research Article 28 May 2024
Chronotropic Incompetence Among People With HIV Improves With Exercise Training in the Exercise for Healthy Aging Study
Matthew S Durstenfeld and othersThe Journal of Infectious Diseases, jiae284, https://doi.org/10.1093/infdis/jiae284Published: 28 May 2024 Section: Major ArticleA secondary analysis of the Exercise for Healthy Aging Study demonstrated that chronotropic incompetence (inability to increase heart rate during exercise), which is a common cause of reduced fitness among people with HIV, improves with supervised exercise training.
-
Corrected Proof
Research Article 28 May 2024
Viral Genomic Variation and the Severity of Genital Herpes Simplex Virus-2 Infection as Quantified by Shedding Rate: A Viral Genome-Wide Association Study
Amanda M Casto and othersThe Journal of Infectious Diseases, jiae283, https://doi.org/10.1093/infdis/jiae283Published: 28 May 2024 Section: Major ArticleThe severity of genital herpes varies widely among individuals with HSV-2 infection. The impact of viral genomics on this variation has not previously been examined. Here we identify 3 variants that are individually and collectively associated with genital herpes severity.
-
Corrected Proof
Brief Report 28 May 2024
Spliced-Leader RNA as a Dynamic Marker for Monitoring Viable Leishmania Parasites During and After Treatment
Rik Hendrickx and othersThe Journal of Infectious Diseases, jiae219, https://doi.org/10.1093/infdis/jiae219Published: 28 May 2024 Section: Brief ReportComprehensive in vitro and in vivo experiments and analyses in patients with visceral leishmaniasis identify spliced-leader RNA (SL-RNA) as a parasite viability marker. An optimized protocol allows the versatile detection of SL-RNA and other molecular markers for individualized patient management.
-
Corrected Proof
Brief Report 28 May 2024
Respiratory Viral Coinfections in Pediatric Patients in the Primary Care Setting: A Multicenter Prospective Study Within the COPEDICAT Network
Cristina Andrés and othersThe Journal of Infectious Diseases, jiae279, https://doi.org/10.1093/infdis/jiae279Published: 28 May 2024 Section: Brief ReportA 2-year study in Catalonia, Spain, examined respiratory virus prevalence and coinfection dynamics among 1276 pediatric patients. Findings reveal complex patterns, including a 23.8% SARS-CoV-2 coinfection rate, informing postpandemic viral interactions for public health strategies.
-
Corrected Proof
Research Article 27 May 2024
Whispers in the Wind: Face Mask Sampling for Mycobacterium tuberculosis Detection in Children With Pulmonary Tuberculosis
Lennard Meiwes and othersThe Journal of Infectious Diseases, jiae282, https://doi.org/10.1093/infdis/jiae282Published: 27 May 2024 Section: Major ArticleWe report the first use of face mask sampling for M. tuberculosis detection in children. In vitro experiments showed a limit of 95% detection of 3.75 CFU. However, M. tuberculosis DNA was not detected from 30 mask worn by 10 children with tuberculosis.
-
Corrected Proof
Research Article 27 May 2024
Ebola Virus–Specific Neutralizing Antibody Persists at High Levels in Survivors 2 Years After Resolution of Disease in a Sierra Leonean Cohort
Nell G Bond and othersThe Journal of Infectious Diseases, jiae155, https://doi.org/10.1093/infdis/jiae155Published: 27 May 2024 Section: Major ArticleWe measured Ebola virus–specific IgG antibody and antibody neutralization potential in a cohort of 357 Ebola virus disease survivors and 969 contacts. We found that Ebola virus IgG and antibody neutralization potential persisted in the survivor population but was variable across the cohort.
-
Corrected Proof
Research Article 24 May 2024
Characterizing the Etiology of Recurrent Tuberculosis Using Whole Genome Sequencing: Alaska, 2008–2020
Yuri P Springer and othersThe Journal of Infectious Diseases, jiae275, https://doi.org/10.1093/infdis/jiae275Published: 24 May 2024 Section: Major ArticleTwo-thirds of episodes of recurrent tuberculosis in American Indian or Alaska Native (AIAN) persons in Alaska during 2008 to 2020 were attributed to reinfection based on whole genome single-nucleotide polymorphism (wgSNP) distance data combined with results of phylogenetic analyses.
-
Corrected Proof
Brief Report 23 May 2024
Hepatitis B Virus DNA and RNA Persist in Liver After Serologic Recovery in Persons With Hepatitis C Virus
Tanner Grudda and othersThe Journal of Infectious Diseases, jiae248, https://doi.org/10.1093/infdis/jiae248Published: 23 May 2024 Section: Brief ReportPeople who spontaneously recover from hepatitis B virus infection may have a long-lived viral reservoir that explains reactivation during immunosuppression. We studied liver biopsy specimens from 13 people with spontaneous recovery and directly quantified the reservoir and its transcriptional activity.
-
Corrected Proof
Research Article 23 May 2024
Fecal Microbiota and Volatile Metabolome Pattern Alterations Precede Late-Onset Meningitis in Preterm Neonates
Nina M Frerichs and othersThe Journal of Infectious Diseases, jiae265, https://doi.org/10.1093/infdis/jiae265Published: 23 May 2024 Section: Major ArticleThe fecal microbiota and volatile metabolome are altered in preterm infants prior to late-onset meningitis. A prediction model based on 6 bacterial genera and species could accurately predict late-onset meningitis 1–3 days before clinical onset with an AUC of 0.88.
-
Editor's Choice
Corrected Proof
Editorial 23 May 2024
Oops, the Microbes Did It Again: Gut Dysbiosis Precedes Late-Onset Meningitis
Samantha A Whiteside and Audrey R Odom JohnThe Journal of Infectious Diseases, jiae266, https://doi.org/10.1093/infdis/jiae266Published: 23 May 2024 Section: Editorial -
Accepted Manuscript
Research Article 23 May 2024
The clinical effectiveness of Fidaxomicin compared to Vancomycin in the treatment of Clostridioides difficile infection, a single center real-world experience
Majd Alsoubani and othersThe Journal of Infectious Diseases, jiae274, https://doi.org/10.1093/infdis/jiae274Published: 23 May 2024 Section: Major ArticleThis study evaluated the treatment effectiveness of fidaxomicin compared to vancomycin in a single center real world study. Our results showed that fidaxomicin was associated with a reduced risk of Clostridioides difficile infection recurrence even after adjusting for ribotype 027.
-
Corrected Proof
Research Article 23 May 2024
Microheterogeneity of Transmission Shapes Submicroscopic Malaria Carriage in Coastal Tanzania
Tyler Rapp and othersThe Journal of Infectious Diseases, jiae276, https://doi.org/10.1093/infdis/jiae276Published: 23 May 2024 Section: Major ArticleIn Bagamoyo, Tanzania, roughly two-thirds of asymptomatic malaria in >5 year-olds is submicroscopic, only detectable by polymerase chain reaction. Submicroscopic carriage and the proportion of submicroscopic carriers who later develop patent malaria are correlated with local village-level malaria prevalence.
-
Corrected Proof
Letter 22 May 2024
Reply to Barajas-Ochoa: The Imperative to Integrate International Medical Graduates into the Infectious Diseases Physician-Scientist Pathway: Expanding Opportunities and Overcoming Barriers
Talia H Swartz and othersThe Journal of Infectious Diseases, jiae272, https://doi.org/10.1093/infdis/jiae272Published: 22 May 2024 Section: Correspondence -
Corrected Proof
Research Article 22 May 2024
Testing and Treatment Interventions in Community Settings Key to Controlling a Recent Human Immunodeficiency Virus Outbreak Among People Who Inject Drugs in Glasgow: A Modeling Study
Lara I Allen and othersThe Journal of Infectious Diseases, jiae206, https://doi.org/10.1093/infdis/jiae206Published: 22 May 2024 Section: Major Article -
Corrected Proof
Letter 22 May 2024
Comment on: A Call to Action: Urgently Strengthening the Future Physician-Scientist Workforce in Infectious Diseases
Aldo Barajas-OchoaThe Journal of Infectious Diseases, jiae271, https://doi.org/10.1093/infdis/jiae271Published: 22 May 2024 Section: Correspondence -
Corrected Proof
Research Article 21 May 2024
Health Care Personnel Workdays Lost and Direct Health Care Salary Costs Incurred due to COVID-19 Infection in the Age of Widespread Vaccine Availability
Liam Townsend and othersThe Journal of Infectious Diseases, jiae223, https://doi.org/10.1093/infdis/jiae223Published: 21 May 2024 Section: Major ArticleThe factors affecting COVID-19–related HCW workdays lost and associated health care personnel costs are incompletely understood. Here, workdays lost were associated with incomplete primary COVID-19 vaccination course. Being unvaccinated, older age, and male were associated with increased costs.
-
Editor's Choice
Corrected Proof
Editorial 21 May 2024
The iciHHV-6 Sense: Sensing the Source and Relevance of Human Herpesvirus 6 (HHV-6) DNA in the Transplant Recipient With Inherited Chromosomally Integrated HHV-6
Madeleine R Heldman and othersThe Journal of Infectious Diseases, jiae269, https://doi.org/10.1093/infdis/jiae269Published: 21 May 2024 Section: Editorial -
Editor's Choice
Corrected Proof
Research Article 20 May 2024
Reactivation of a Transplant Recipient's Inherited Human Herpesvirus 6 and Implications to the Graft
Leo Hannolainen and othersThe Journal of Infectious Diseases, jiae268, https://doi.org/10.1093/infdis/jiae268Published: 20 May 2024 Section: Major Article -
Corrected Proof
Review Article 20 May 2024
The Importance of Including Long COVID Outcomes When Developing Novel Treatments for Acute COVID-19
Chloe Connor and Holly A TaylorThe Journal of Infectious Diseases, jiae270, https://doi.org/10.1093/infdis/jiae270Published: 20 May 2024 Section: ReviewThis article reviews current US clinical trials of acute COVID-19 treatments, determines that only 1 study (N = 19) is incorporating long COVID measurements, and highlights 7 reasons to include such measurements and actionable steps to achieve this aim.
-
Corrected Proof
Research Article 17 May 2024
Maternal Bacille Calmette-Guérin Scars and Mortality Risk for Male and Female Newborns: Observational Study From Guinea-Bissau
Frederik Schaltz-Buchholzer and othersThe Journal of Infectious Diseases, jiae262, https://doi.org/10.1093/infdis/jiae262Published: 17 May 2024 Section: Major ArticleIn a large cohort of bacille Calmette-Guérin–vaccinated newborns followed to 6 months of age, admission severity and all-cause mortality were reduced among males born to mothers who had a bacille Calmette-Guérin scar vs males born to mothers without a scar.
-
Corrected Proof
Brief Report 16 May 2024
Extended-Spectrum β-Lactamase Shigella sonnei Cluster Among Men Who Have Sex With Men in Chicago, Illinois, July–October 2022
Emily A G Faherty and othersThe Journal of Infectious Diseases, jiae235, https://doi.org/10.1093/infdis/jiae235Published: 16 May 2024 Section: Brief ReportWe investigated a cluster of extended-spectrum β-lactamase–producing Shigella sonnei predominantly affecting men who have sex with men. Several isolates demonstrated resistance to multiple classes of antibiotics, highlighting the importance of Shigella prevention education along with other sexual health messaging.
-
Accepted Manuscript
Research Article 16 May 2024
Population Effectiveness of Dolutegravir Implementation in Uganda - A Prospective Observational Cohort Study (DISCO): 48-week Results
Suzanne M McCluskey and othersThe Journal of Infectious Diseases, jiae260, https://doi.org/10.1093/infdis/jiae260Published: 16 May 2024 Section: Major ArticleAmong people living with HIV in Uganda who transitioned to TLD, we observed high rates of viral suppression, high tolerability, and no emergent drug resistance, all of which support use of TLD as the preferred first-line regimen in the region.
-
Corrected Proof
Research Article 16 May 2024
The Risk of SARS-CoV-2 Transmission in Community Indoor Settings: A Systematic Review and Meta-analysis
Mark Rohit Francis and othersThe Journal of Infectious Diseases, jiae261, https://doi.org/10.1093/infdis/jiae261Published: 16 May 2024 Section: Major ArticleWe conducted a systematic review and meta-analysis to estimate the risk of SARS-CoV-2 transmission in community indoor settings. We found that risk was greatest in settings where singing and exercising occurred and recommend implementing effective mitigation measures in these settings.
-
Corrected Proof
Research Article 14 May 2024
Antibiotic Resistance of Urinary Tract Infection Recurrences in a Large Integrated US Healthcare System
Jennifer H Ku and othersThe Journal of Infectious Diseases, jiae233, https://doi.org/10.1093/infdis/jiae233Published: 14 May 2024 Section: Major ArticleAmong adults with urinary tract infection (UTI) during 2016–2020, 19% had culture-confirmed UTI recurrences, primarily caused by Escherichia coli. Antibiotic nonsusceptibility increased for subsequent UTIs; for the sixth UTI recurrence, 65% and 20% had isolates nonsusceptible to ≥1 and ≥3 antibiotic classes, respectively.
-
Corrected Proof
Research Article 14 May 2024
Hemagglutinin Stalk-Specific Fc-Mediated Functions Are Associated With Protection Against Influenza Illness After Seasonal Influenza Vaccination
Boitumelo M Motsoeneng and othersThe Journal of Infectious Diseases, jiae241, https://doi.org/10.1093/infdis/jiae241Published: 14 May 2024 Section: Major ArticleThis study shows that hemagglutinin (H1) stalk-specific Fc-mediated functions are associated with protection against influenza illness after immunization with a seasonal trivalent inactivated influenza vaccine (TIV) during pregnancy. These data may inform correlates of protection for future HA stalk-based influenza vaccines.
-
Corrected Proof
Research Article 14 May 2024
Distinct Gut Microbiota Signatures Associated With Progression of Atherosclerosis in People Living With Human Immunodeficiency Virus
Mar Masiá and othersThe Journal of Infectious Diseases, jiae243, https://doi.org/10.1093/infdis/jiae243Published: 14 May 2024 Section: Major ArticleThis prospective study investigated longitudinal associations between gut microbiota dynamics and the progression of carotid intima-media thickness in individuals with human immunodeficiency virus. Subclinical atherosclerosis progression was consistently linked with Agathobacter and Ruminococcus 2, whereas nonprogression was consistently associated with Prevotella 7.
-
Editor's Choice
Corrected Proof
Editorial 14 May 2024
The Gut Microbiome: Another Piece in the Puzzle of HIV-Associated Atherosclerosis
Sergio Serrano-Villar and Esteban MartínezThe Journal of Infectious Diseases, jiae244, https://doi.org/10.1093/infdis/jiae244Published: 14 May 2024 Section: Editorial Commentary -
Corrected Proof
Research Article 14 May 2024
The Capsular Polysaccharide Obstructs Wall Teichoic Acid Functions in Staphylococcus aureus
Esther Lehmann and othersThe Journal of Infectious Diseases, jiae188, https://doi.org/10.1093/infdis/jiae188Published: 14 May 2024 Section: Major ArticleCapsule and wall teichoic acids shape the cell envelope of Staphylococcus aureus and are key virulence determinants of the bacterium. We show the capsule obstructs major functions of wall teichoic acids such as cell adhesion, phage absorption, and IgG deposition.
-
Corrected Proof
Research Article 14 May 2024
Longitudinal Analysis of Nursing Home Residents’ T-Cell Responses After SARS-CoV-2 mRNA Vaccinations Shows Influence of Biological Sex and Infection History
Carson L Smith and othersThe Journal of Infectious Diseases, jiae234, https://doi.org/10.1093/infdis/jiae234Published: 14 May 2024 Section: Major ArticleT-cells responses in nursing home residents (NHR) and health care workers (HCW) after SARS-CoV-2 mRNA vaccination show that both groups have vaccine-induced responses, but prior infection and female sex contribute to higher responses in NHR but not HCW.
-
Corrected Proof
Research Article 14 May 2024
The Effect of Gastrointestinal Graft-Versus-Host Disease and Diarrhea on the Pharmacokinetic Profile of Sotrovimab in Hematopoietic Stem Cell Transplant Recipients
Jim Boonyaratanakornkit and othersThe Journal of Infectious Diseases, jiae236, https://doi.org/10.1093/infdis/jiae236Published: 14 May 2024 Section: Major Article -
Corrected Proof
Research Article 13 May 2024
Serological Evidence of Mpox Virus Infection During Peak Mpox Transmission in New York City, July to August 2022
Preeti Pathela and othersThe Journal of Infectious Diseases, jiae181, https://doi.org/10.1093/infdis/jiae181Published: 13 May 2024 Section: Major ArticleA New York City serosurvey in Summer 2022 found that 6% of participants without prior mpox diagnoses or histories of smallpox or mpox vaccination had antibodies to mpox, indicating the presence of infections that can contribute to asymptomatic transmission.
-
Corrected Proof
Review Article 10 May 2024
Neutrophil Extracellular Traps: An Emerging Therapeutic Target to Improve Infectious Disease Outcomes
Angela Meier and othersThe Journal of Infectious Diseases, jiae252, https://doi.org/10.1093/infdis/jiae252Published: 10 May 2024 Section: ReviewNeutrophil extracellular traps (NETs) aid in the clearance of pathogens, but their overproduction may drive massive inflammatory responses, contributing to morbidity and mortality. Despite the importance of NETs in the pathophysiology of infections, many clinicians are unaware of these processes.
-
Corrected Proof
Research Article 9 May 2024
Humoral Correlates of Protection Against Influenza A/H3N2 Virus Infection
Gregory Hoy and othersThe Journal of Infectious Diseases, jiae258, https://doi.org/10.1093/infdis/jiae258Published: 9 May 2024 Section: Major ArticleThe humoral correlates of protection against influenza A/H3N2 virus are poorly understood. We found that the hemagglutinin stalk is independently associated with protection against A/H3N2 virus infection, and that responses measured using hemagglutinin inhibition assays varied across season and age.