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Sam W Allen, Gabriel Ribeiro Dos Santos, Kishor K Paul, Repon Paul, Mohammad Ziaur Rahman, Mohammad Shafiul Alam, Mahmudur Rahman, Hasan Mohammad Al-Amin, Jessica Vanhomwegen, Scott C Weaver, Taylor Smull, Kyu Han Lee, Emily S Gurley, Henrik Salje, Results of a nationally representative seroprevalence survey of chikungunya virus in Bangladesh, The Journal of Infectious Diseases, 2024;, jiae335, https://doi.org/10.1093/infdis/jiae335
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Abstract
There is an increasing global burden from chikungunya virus (CHIKV). Bangladesh reported a major epidemic in 2017, however, it was unclear if there had been prior widespread transmission. We conducted a nationally representative seroprevalence survey in 70 randomly selected communities immediately prior to the epidemic. We found 69/2,938 (2.4%) of sampled individuals were seropositive to CHIKV. Being seropositive to dengue virus (aOR 3.13 [95% CIs: 1.86-5.27]), male sex (aOR 0.59 [95% CIs: 0.36-0.99]), and community presence of Aedes aegypti mosquitoes (aOR: 1.80, 95% CI: 1.05–3.07) were significantly associated with CHIKV seropositivity. Using a spatial prediction model, we estimated that across the country, 4.99 (95% CI: 4.89 - 5.08) million people had been previously infected. These findings highlight high population susceptibility prior to the major outbreak and that previous outbreaks must have been spatially isolated.
Author notes
Emily S. Gurley and Henrik Salje joint senior authors