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Ghalia Sbaa, Nicolas Delettre, Cécile Guyonnet, Sébastien Le Huu Nghia, Caroline Joubrel-Guyot, Céline Plainvert, Claire Poyart, Asmaa Tazi, Recurrent Group B Streptococcus Neonatal Invasive Infections, France, 2007–2021, The Journal of Infectious Diseases, 2024;, jiae307, https://doi.org/10.1093/infdis/jiae307
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Abstract
Recurrence is a rare complication of group B Streptococcus (GBS) neonatal infections. We conducted a retrospective observational study on GBS neonatal invasive infections in France from 2007 to 2021. A total of 1527 cases were reported, of which 36 (2.36%) were recurrent. Recurrence mainly concerned preterm (68%) and low-birth-weight (72%) infants and was associated with the hypervirulent GBS clonal complex 17 (83%; odds ratio, 2.86 [95% confidence interval, 1.18–6.92]). No β-lactam–tolerant strains were identified, and bacterial whole-genome sequencing could not reveal any specific feature associated with recurrence. Large-cohort studies should be undertaken to address the optimal management of these uncommon diseases.