Cancer cells salvage purine nucleotides to fuel tumor growth, including purines in foods we eat, an important discovery with implications for cancer therapies from research by Children’s Medical Center Research Institute at UT Southwestern published in Cell.
A team led by UT Southwestern Medical Center researchers has discovered a new way that cells regulate senescence, an irreversible end to cell division.
The study, published in Cell Reports, reveals how IRF1 can both hinder and help the body's immune response to tumors, depending upon which cells the protein is found in.
Discover research from UC San Diego showing how stem cell-derived therapy, targeting treatment-resistant liver cancer through genetically modified NK cells, offers promising new avenues for immunotherapy.
Researchers at the University of Michigan Rogel Cancer Center found that a molecular mechanism, shared in cancer and pregnancy, that suppresses the immune system. Block this mechanism, called B7-H4, and the immune system revs up to slow cancer’s growth.
In a recent study, researchers at Johns Hopkins Medicine suggest the cell’s messenger RNA (mRNA) — the major translator and regulator of genetic material — along with a critical protein called ZAK, spur the cell’s initial response to UV radiation damage and play a critical role in whether the cell lives or dies.
A new study led by researchers at Moffitt Cancer Center introduces an adaptive therapy approach that could optimize PARP inhibitor maintenance therapy, offering a more personalized and potentially less toxic treatment option for patients. Their work is featured as the cover article of the June 19 issue of Cell Systems.
Researchers from Johns Hopkins Medicine and the National Institutes of Health’s National Institute on Aging say their study of 40 older adults with obesity and insulin resistance who were randomly assigned to either an intermittent fasting diet or a standard healthy diet approved by the U.S. Department of Agriculture (USDA) offers important clues about the potential benefits of both eating plans on brain health.
Harvard Medical School researchers are studying one of the most mysterious — and most essential — senses
The discovery of how intricate networks of blood vessels in the eye and brain are formed could inspire new treatments for glaucoma, diabetic retinopathy, and stroke.
Leptomeningeal disease is a rare but lethal complication faced by late-stage melanoma patients. It occurs when cancer cells spread to the membranes covering the brain and spinal cord, or the leptomeninges. This condition, which affects 5% to 8% of melanoma patients, often leads to rapid deterioration and is notoriously resistant to therapies. However, a new Moffitt Cancer Center study, published today in Cell Reports Medicine, uncovers the mechanisms that drive this drug resistance, offering new avenues for potential treatments.
Study finds that mesalamine, a common anti-inflammatory drug, can fight the fungus Candida albicans in the gut, potentially preventing the risk of invasive candidiasis in patients with blood cancers.
A roundup of the latest medical discoveries and faculty news at Cedars-Sinai.
University of Illinois Chicago engineers have helped design a new method to make hydrogen gas from water using only solar power and agricultural waste such as manure or husks. The method reduces the energy needed to extract hydrogen from water by 600%, creating new opportunities for sustainable, climate-friendly chemical production.
Repeated vaccination and infection leads T cells and B cells to build an "immunity wall"
UC San Diego biologists have provided new insights on a longstanding puzzle in biology: How complex organisms arise from a single fertilized cell. Producing a new “gene atlas” with 4-D imaging, the researchers captured unprecedented insights on how embryonic development unfolds.
Scientists with Cedars-Sinai Guerin Children’s, the University of California, San Francisco (UCSF), and other institutions have identified the critical first steps in how the digestive system develops.
Rutgers Health researchers found that long COVID is associated with active inflammatory changes in the nervous system, but the condition is distinct from Alzheimer’s disease and other neurodegenerative disorders.
Researchers from Johns Hopkins Medicine say they have uncovered insights as to why lupus symptoms and severity present differently in individuals with the autoimmune condition, which affects up to 1.5 million Americans.
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