BASF Pharma Solutions

What a great event highlighting our commitment to supporting the pharmaceutical industry in Indonesia! #Pharmaceuticals #PharmaIndustry #Indonesia

Control nitrosamines with low nitrite PVP excipients from BASF. Nitrosamines are chemical compounds that can be formed from the reaction of amines (typically from APIs) with a nitrosating agent like nitrite, that may come from excipients, water, etc. Reducing the risk of nitrosamine formation in drug products is essential to create safe medicines. To support drug formulators in reducing the risk of nitrosamine formation, we provide: ▶️ Nitrosamine risk assessments with average nitrite values and LOQ (Limit of Quantitation – the lowest amount of nitrite we can see and reliably measure). ▶️ Our validated analytical methods so you can confidently measure nitrites at your site. ▶️ Technical guidance on formulation strategies for nitrosamine reduction (antioxidants, BASF’s Virtual Pharma Assistant platform ZoomLab®). More than 80 years ago we invented PVPs, and we fully understand their chemistry. Our povidones, copovidones and crospovidones have always been low nitrite grades with high lot-to-lot consistency. Our BASF Pharma Solutions experts can support you in ensuring patient safety and regulatory compliance! Contact us here: https://lnkd.in/ddyPpfGx #RegXcellence #pharma #digitalpharma #regulatory #pharmamanufacturing #nitrosamines #excipients #APIs

Did you know that Kolliphor® CS 12 and Kolliphor® CS 20 are two powerful emulsifiers that can be used to create stable oil-in-water emulsions? These ethoxylated emulsifiers utilize phase inversion technology (PIT) to form emulsions with very small droplet sizes, resulting in stable emulsions. By incorporating Kolliphor® CS 12 and Kolliphor® CS 20 into topical formulations, you can stabilize oil-in-water creams or create robust foams. These emulsifiers act as surface-active substances that reduce the interfacial tension between the oil and water phases of an emulsion, ensuring better stability and effectiveness. Both are suitable for hot processing, stable with acidic, basic, and ionic excipients, and widely used to formulate pharmaceutical oil-in-water emulsions. If you're looking to enhance the stability and sensory properties of your pharmaceutical foam formulations, look into our whitepaper about Kolliphor® CS 12 and Kolliphor® CS 20! For more product information or to request a sample visit our website: Kolliphor® CS 12: https://lnkd.in/e_MwRJVv Kolliphor® CS 20: https://lnkd.in/ekP86vKk #Topicals #Transdermals #Pharma #Formulation #foams #DrugDevelopement #DrugManufacturing #Topicals2024

What do you know about Nitrosamines? Nitrosamines are a group of chemical compounds that can be formed when amines react with, e.g., nitrites. Active Pharmaceutical Ingredients (APIs) that have secondary or tertiary amines can react with nitrites potentially coming from excipients to form nitrosamines in drug products: ▶️ ~ 40% of APIs are at risk of forming N-nitrosamines. ▶️ Some nitrosamines are classified as probable human carcinogens. ▶️ Depending on the predicted carcinogenic potency, regulatory agencies have set acceptable intake limits, with the strictest being 18 ng/day. To reduce their risk of formation in drug products, authorities have asked manufacturers to conduct nitrosamine risk assessments and recommended analytical testing of incoming raw materials if nitrite values are not known. Learn more about nitrosamines, following our “Weekly Wednesdays” post series for this month! For more information about our support on this topic – click here: https://lnkd.in/dHPKMp53 #RegXcellence #pharma #digitalpharma #regulatory #pharmamanufacturing #nitrosamines #excipients #APIs

Introducing Kollicream® 3 C, the perfect multifunctional excipient for topical dosage forms! Kollicream® 3 C is a clear, mildly yellowish, medium polar oil with a slightly fatty odor. Due to its high spreading value, this product is well-suited for use in pharmaceutical skin care preparations such as oil-in-water emulsions, lotions, and foams. One of the key benefits of Kollicream® 3 C is its medium spreadability, which allows for easy and even application on the skin. This excipient also enhances the skin penetrability of certain drugs, making it an excellent choice for formulations that require effective drug delivery. Additionally, it is extremely mild upon application, minimizing any potential irritation or discomfort. Don't miss out on the opportunity to optimize patient compliance and acceptance by formulating your topical and transdermal dosage forms with Kollicream® 3 C! Request access to download our formulary here: https://lnkd.in/eSuCMzrW Or request your sample now: https://lnkd.in/eKqt2gXx #Topicals #Transdermals #Pharma #Formulation #foams #DrugDevelopement #DrugManufacturing #Topicals2024

🏭 Join us as we explore the fascinating world of the BASF Verbund! In our Verbund, we intelligently connect our production plants and technologies to efficiently use resources and leverage our expertise. There are currently six, soon to be seven, Verbund sites globally, supporting customers and partners in almost every country in the world. The Verbund system creates efficient value chains that extend from basic chemicals right through to high-value-added products. In addition, the by-products of one plant can be used as the starting materials of another. In this system, chemical processes consume less energy, produce higher product yields and conserve resources. In that manner, we save on raw materials and energy, minimize emissions, cut logistics costs and exploit synergies.   Learn more about how the Verbund empowers us to deliver cutting-edge solutions that meet the evolving needs of our customers: https://lnkd.in/eCgEGGKd   #BASFVerbund #Reliability #Sustainability #Innovation

Pharmaceutical grade excipients are the right choice for your topical formulation! Pharmaceutical foams are specifically designed for use in the pharma industry, delivering active pharmaceutical ingredients (APIs) to the skin or mucous membranes for therapeutic purposes. These foams are often used for localized drug delivery, such as in dermatology or gynecology, where they can provide targeted treatment to specific areas. They are formulated to be stable, safe, and effective in delivering the desired medication. Foam rinse-off formulations and cleansers are driven by surfactant science, which involves the use of surface-active agents that reduce the surface tension of liquids, allowing them to form stable foams. If you are looking for a pharmaceutical foaming agent with greater foaming capacity, you can try our Kolliphor ® SLS. The pharmaceutical excipient Kolliphor ® SLS is a surfactant to enhance foam stability and volume. This excipient can be used to create a rich and abundant foam to achieve a satisfying user experience.   On the other hand, if you prefer a milder foam, you can look into our topical foam excipient Kolliphor ® P 188. Kolliphor ® P 188 is a nonionic surfactant that is known for its mildness and gentle cleansing properties. It can provide a softer and more delicate foam that is suitable for sensitive skin or for those who prefer a gentler cleansing experience.   Watch our video “Formulating foams” to see how to create foams with the right excipients for your topical applications: https://lnkd.in/ext4dQJW   #Topicals #Pharma #Formulation #foams #DrugDevelopement #DrugManufacturing #Topicals2024

As Pride Month is in full swing, we want to reflect on the importance of fostering an inclusive and accepting workplace regardless of gender, cultural, religious or social background, sexual orientation or identity, origin or physical integrity. At BASF, we welcome ALL talents. There is no place for discrimination. We address unconscious bias, stereotypes and prejudices at all levels and promote an equitable and respectful working environment in which everyone is welcome as they are and feel valued and empowered to contribute with their authentic selves.   Join Jeffrey DeAlmeida, Senior Vice President of BASF Pharma Solutions, and BASF in sparking conversations and creating a culture of openness, acceptance and respect. Let's celebrate diversity and be allies today, this #PrideMonth and all year round! 🌈   #BASFpride #Diversity #Inclusion

Topical foams as a consumer-friendly dosage form are growing in popularity within the pharmaceutical industry, and in some cases preferred by panelists over creams. This uptake in popularity can be attributed to their ease of application, pleasing sensory properties, and ability to effectively deliver drugs through the skin. Due to their ability to spread and cover a larger surface area, foams are particularly useful for delivering medications to treat skin conditions such as acne, psoriasis, and eczema. Foams are formulations that consist of a gas dispersed within a liquid or solid matrix. The gas bubbles within the liquid or solid matrix give foams their characteristic physical properties, such as low density, high surface area, and excellent spreadability. They usually contain active ingredients, as well as surfactants for foam formation and other excipients. Foam properties such as consistency, viscosity, and spreadability are significantly affected by the selection of the surfactant. To support our customers in finding the best topical formulation, we developed highly active surfactants and excipients for aerosol foams, including Kolliphor® P 188, Kolliphor® CS 12, and Kolliphor® CS 20. To learn more about our topicals solutions portfolio visit our website: https://lnkd.in/e_UAP8E7 #Topicals #Pharma #Formulation #foams #DrugDevelopement #DrugManufacturing #Topicals2024

At BASF, we believe in open dialogue and embracing diversity. 🌈 We strengthen every individual’s sense of belonging by valuing their diverse perspectives and unique qualities. Our workplace is guided by our C-O-R-E values, with “O” being “open.” We want to actively create an environment where everyone feels valued and empowered to contribute being their authentic and best selves.   Join Dr. Martin Volland, President of BASF Nutrition & Health, in sparking conversations and creating a culture of openness, respect, and inclusion. Let's celebrate diversity and be promoters today, this #PrideMonth and all year round!   #BASFpride #Diversity #Inclusion