Conquering Rome in 48 hours—is it even possible? Sure, if what you have in mind is eating a slice of Roman-style pizza right out of a wood-fired oven, sampling a few flavors of gelato that you’ve never heard of, and joining locals as they stroll around the nearest piazza. This two-day itinerary lets you get a real feel for Rome while also savoring a handful of its showstoppers, including the Colosseum and the Sistine Chapel.