Cromwell, Connecticut, United States
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Calling all #Pharmacists - if you are looking to join a world class organization, fast growing pharmacy, finishing your PGY? Just looking to make a…
Calling all #Pharmacists - if you are looking to join a world class organization, fast growing pharmacy, finishing your PGY? Just looking to make a…
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DefenCath® (taurolidine and heparin) and is now available for purchase for BOTH inpatient and outpatient use. Available on contract through Premier…
DefenCath® (taurolidine and heparin) and is now available for purchase for BOTH inpatient and outpatient use. Available on contract through Premier…
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When high blood pressure strikes in a hospital setting, the best course of action is unclear. Dr. Adam Bress chaired a American Heart Association…
When high blood pressure strikes in a hospital setting, the best course of action is unclear. Dr. Adam Bress chaired a American Heart Association…
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Experience & Education
Publications
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Does Insulin Therapy for Type 1 Diabetes Mellitus Protect Against Alzheimer's Disease?
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Alzheimer's disease is the most common cause of dementia in the United States. A better understanding of the disease's underlying pathways may provide novel treatment and/or prevention strategies for this progressive chronic neurodegenerative disorder. In recent years, there has been a growing interest in the possible links between insulin and Alzheimer's disease. Insulin-induced hypoglycemia causes adaptive changes in the brain, including an improved ability to use alternative fuels. Insulin…
Alzheimer's disease is the most common cause of dementia in the United States. A better understanding of the disease's underlying pathways may provide novel treatment and/or prevention strategies for this progressive chronic neurodegenerative disorder. In recent years, there has been a growing interest in the possible links between insulin and Alzheimer's disease. Insulin-induced hypoglycemia causes adaptive changes in the brain, including an improved ability to use alternative fuels. Insulin has been shown to facilitate reduction of intracellular amyloid plaque and downregulation of amyloid-β–derived diffusible ligand-binding sites. Insulin also promotes tau hypophosphorylation, which stabilizes microtubules and promotes tubulin polymerization. Excess exogenous insulin may also play a role in overcoming the decreased utilization and transport of glucose in patients with Alzheimer's disease. Intranasal insulin therapy may have beneficial effects on cognition and function in patients with Alzheimer's disease, as well as having only minor adverse effects, and this route of administration been the focus in clinical trials. These data support the mechanistic pathways that might link excess exogenous insulin administered to patients with type 1 diabetes mellitus to possible protection from Alzheimer's disease and provide a rationale for using insulin to prevent the disease in high-risk patients
Other authorsSee publication
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I had the privilege of presenting on Emerging Health Policies earlier this week at the 2024 ASCO Annual Meeting with Dr. Natalie Dickson and…
I had the privilege of presenting on Emerging Health Policies earlier this week at the 2024 ASCO Annual Meeting with Dr. Natalie Dickson and…
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We are incredibly grateful to have hosted the 5th Annual New England Residency Conference at the University of Saint Joseph and to have had the…
We are incredibly grateful to have hosted the 5th Annual New England Residency Conference at the University of Saint Joseph and to have had the…
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Congratulations to our PGY1 pharmacy residents for presenting their projects at the New England Residency Conference today! #ynhhspharmacy
Congratulations to our PGY1 pharmacy residents for presenting their projects at the New England Residency Conference today! #ynhhspharmacy
Liked by Abdelghany, Osama
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Join NCODA for an informative live webinar on Navigating the Challenges of Drug Shortages. Hear from oncology leaders on the latest insights…
Join NCODA for an informative live webinar on Navigating the Challenges of Drug Shortages. Hear from oncology leaders on the latest insights…
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Thank you to our Connecticut Society of Health-System Pharmacists ( CSHP ) members and industry partners who joined us at our networking event on…
Thank you to our Connecticut Society of Health-System Pharmacists ( CSHP ) members and industry partners who joined us at our networking event on…
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