Molecure

📣 #OATD01 news! Another significant milestone achieved: dosing of the first patient in the phase II clinical trial OATD-01 (KITE) for the treatment of pulmonary sarcoidosis at the clinical site in the UK 👩⚕️ The Phase II study will be conducted in the UK, the US, the European Union and Norway and will involve approximately 100 patients. Patients will take a daily oral dose of 25 mg OATD-01 or placebo for 12 weeks 💊 ➡️ Find out more here: https://lnkd.in/d5jNHc6t

On this World Listening Day, we want to highlight something incredibly important – listening to your body 🌍👂 In today’s fast-paced world, we often forget how crucial it is to pay attention to the signals our bodies send us. At #Molecure, we work every day on innovative solutions to help better understand and care for our health. We encourage you to do the same – take a moment to listen to your body, understand its needs, and respond accordingly. A healthy body is the foundation of well-being and a long life 💪🧬 Take care of yourselves and remember, the most important voice is the one coming from your own body!

We'd like to share the fascinating process of clinical trials, which is crucial for developing new therapies and drugs. Have you ever wondered how this process works? Here are the stages every new therapy goes through 💡 ➡️ Preclinical Phase - before testing in humans, new drugs are evaluated in the lab and on animals to understand how the substance works and if it is safe 🧪 ➡️ Phase I - the first phase of clinical trials involves a small group of healthy volunteers or patients (10-50 people). The aim is to assess the drug's safety, determine dosage, and identify any potential side effects 👩🔬 ➡️ Phase II - the drug is tested on a larger group of patients (50-100 people) suffering from the target disease. The goal is to further evaluate safety and efficacy 👩⚕️ ➡️ Phase III - the most advanced stage involves testing the drug on a large group of patients (300-3000 people). The studies aim to confirm efficacy, monitor side effects, and compare the new therapy with currently available treatments 📊🔍 ➡️ Phase IV - after regulatory approval, the drug reaches the market, but the studies don't stop. In Phase IV, the drug is monitored for long-term efficacy and safety ✅ Each of these stages is essential to ensure that new therapies are both effective and safe for patients. We are proud to be part of this exciting journey in the world of biotechnology! Fate can be altered 🌍💊

World Population Day aims to raise awareness about global population issues. This year's theme is 'To Leave No One Behind, Count Everyone', which draws attention to the inclusive and thorough data collection process. Investing in data collection is important to understand problems, tailor solutions and drive progress 🌍📊   At #Molecure, we are committed to using innovative data solutions to address global health challenges. By focusing on rare diseases, such as sarcoidosis with #OATD01, we exemplify the commitment to leaving no one behind, ensuring that even the most overlooked health challenges receive attention and innovative solutions 💡🔬 Working on addressing the leading cause of death worldwide - cancer #OATD02, we continue to strive for breakthroughs that can save lives and improve health outcomes globally 🧬❤

Today, we'd like to talk about something incredibly important for our health and the future of medicine – clinical trials 🧬 Why are they so crucial? Here are a few key reasons: ➡️ Safety and efficacy: Before introducing a new drug or therapy, it's essential to ensure it's safe and effective. Clinical trials allow us to rigorously test new medical solutions on volunteer and patient groups. ➡️ Advancement of medicine: Clinical trials drive continuous advancements in medicine. New discoveries lead to more effective therapies that can improve the quality of life for patients worldwide. ➡️ Innovation: Bringing new technologies and therapies into clinical practice is only possible through robust research. Clinical trials enable the testing of innovative ideas in real-world conditions. ➡️ Understanding diseases: Clinical trials help us better understand various diseases, their progression, and their impact on the human body. This, in turn, leads to the development of more precise treatment methods. ➡️ Social responsibility: Participating in clinical trials is also a contribution to societal good. Thanks to volunteers and patients, we can develop new medicines that save lives and enhance their quality. At #Molecure, we are conducting two clinical trials: for #OATD01 in phase II and #OATD02 in phase I. Follow our progress in this exciting journey! 📈

Today we celebrate Research Appreciation Day, a day dedicated to honoring the work of the thousands of health researchers around the world who make a difference in people's lives. Through the passion and determination of our scientists, we collectively contribute to advancements in medicine and health. At #Molecure, we firmly believe that "Fate can be altered" and our researchers embody this motto by tirelessly working to change the course of diseases and improve patient outcomes. We are proud of their work and grateful for their invaluable contributions to improving the quality of life for patients worldwide! 💕 Check out our infographic below to see which #Molecure departments are driving this incredible progress! ⬇️

Bonjour! #Molecure's Medicinal Chemist, Marcin Grajda, and Senior Scientist, Piotr Niedziejko, are attending the 58th International Conference on Medicinal Chemistry in Bordeaux, France 🇫🇷 where our team is presenting among others poster about #OATD01, a clinical candidate in Phase II 👩⚕️ The conference focuses on 'Interfacing Chemical Biology and Drug Discovery' and features 18 plenary lectures and 6 short lectures. The high quality and diversity of the scientific program provide 3 days of intensive learning and inspiration, as well as networking opportunities and insights into the latest advancements in the field 🔬💡

Thank you for inviting us to The European Congress of Life Sciences EUROBIOTECH 🌍 It was truly a pleasure to participate and share our experiences and knowledge with other industry experts in a panel discussion held by Marta Winiarska from BioInMed We look forward to future editions and further collaboration! 🤝✨

On Friday at #Molecure, we had the pleasure of hosting a lecture by Prof. Bartek Wilczynski on "Where is the place of AI in life sciences?" 🤖🧬 Prof. Wilczyński, a computational biologist working on regulatory genomics at the University of Warsaw, has a Ph.D. in Mathematics and specializes in applying machine learning techniques to OMICS-data analysis in gene regulation. His work spans multiple areas - from using neural networks to predict activity of non-coding sequences to fast coarse-grained monte-carlo simulations of chromatin structure. One of his most recognized contributions is the development of ML-based models of gene regulation in fruitflies. Currently, his primary focus is on leveraging artificial neural networks to predict functional fragments of DNA and RNA. These innovative approaches have been instrumental in uncovering pathological mechanisms in human diseases, such as gliomas, and understanding regulatory landscapes in various biological contexts 🧠🔬 We are grateful for his insights and inspiring lecture! 🌟

We are thrilled to announce the publication of #Molecure’s team collaborative work with Prof. Sebastian Kmiecik, featured in NAR Nucleic Acids Research! 🎉 Our latest study evaluates six standalone #RNA 3D structure prediction methods, as well as the newly released #AlphaFold 3. By using a diverse set of RNA structures, we uncovered fascinating insights into the strengths and weaknesses of these methods. Some excel in predicting global folds, while others in modeling local interactions 🔬 This article confirms our unique expertise in the area of development of new drugs modulating mRNA function. Discover how these advances can pave the way for therapeutic breakthroughs. Check out our publication for more details on the potential and challenges in RNA–ligand interaction modeling! ✨ ➡️ https://lnkd.in/dUY5CheN