Lorenza Rimassa

"Long-Term Complications after Allogeneic Hematopoietic Stem Cell Transplantation with Treosulfan- or Busulfan-Based Conditioning in Pediatric Patients with Acute Leukemia or Myelodysplastic Syndrome: Results of an Associazione Italiana Ematologia Oncologia Pediatrica Retrospective Study" - In hematopoietic #stemcell transplantation (HSCT), treosulfan is emerging as a valid alternative to #busulfan in the conditioning regimen for hematologic malignancies. - #Treosulfan is correlated with a reduced incidence of long-term gonadal toxicity https://lnkd.in/dWeHfPDc #RicercalnnovazioneQualitàdellaVita #clinicalresearch Francesco Saglio, Marco Zecca, Adriana BALDUZZI, Arcangelo Prete,  Francesco Paolo Tambaro, Maura Faraci, Franca Fagioli 

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📣 New #Review Published Online 📣 📰 Uric acid in atherosclerosis and cardiovascular diseases: innocent bystander or ruthless killer? 🖋 Authors: Giovanni Cimmino, Francesco Natale, Rosa Franzese, Mariarosaria Morello, Gisella Titolo, Noemi Mollo, Valentina Maria Caso, Paolo Golino, Plinio Cirillo ⭐ Keywords: #Hyperuricemia, #inflammation, #CardiovascularRisk, #atherosclerosis, #CardiovascularDiseases 💡 The purpose of this review is to briefly describe the main clinical and epidemiological evidence supporting the role of hyperuricemia as a possible emerging cardiovascular risk factor and to analyze the potential pathophysiological mechanisms through which elevated UA levels may exert a detrimental effect on the cardiovascular system. 🔎 Read the full article at https://lnkd.in/gKKNc-PV 🔎 PDF: https://lnkd.in/guyfVcjU This article belongs to the special issue "Hyperuricemia: current state and prospects" https://lnkd.in/gE8yFMud

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Want to hear the latest updates on the current clinical trials in #Parkinsons? 💭 🧠 Check out our interview with Stocchi Fabrizio, MD, PhD of Sapienza Università di Roma from #ADPD2024: 👉 ​​https://ow.ly/LJgs50Rn33s One key approach is the targeting of #αsynuclein and in this space, #prasinezumab is one of the most advanced investigational agents The antibody targets aggregated α-synuclein to prevent cell-to-cell transmission. While the Phase II #PASADENA trial missed the primary efficacy outcome of change on the MDS-#UPDRS global score, several positive signals were seen in secondary endpoints, including a trend towards benefit on the UPDRS Part III, which measures decline in #motorfunction 🌟 Other α-synuclein-targeting agents are also in development, including small molecule α-syn misfolding inhibitors, such as UCB0599 which is currently undergoing Phase II evaluation, and #vaccinations, including ACI-7104.056 💡 #MovementDisorders #CTSM #VJNeurology

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A budget impact model was developed to assess the health and economic impact of introducing dapagliflozin in the italian GPs setting. An interesting paper from prof Lorenzo G Mantovani research team. The question in my mind is: how many patients from this cohort have been tested for #NTproBNP before treatment?

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As part of the #PRO4ALL project, we have just published a comprehensive repository of 386 patient-, caregiver-, observer-reported measures in oncology:

▶️ 92% were validated ▶️ 17% had evidence on minimal important difference (MCID)
▶️ most common recall period was "last week" ▶️ most common outcome domain were emotional functioning/wellbeing (22%) and physical functioning (15.7%) This archive can guide selection of the most suitable measures to foster a patient-centered approach in clinical trials, clinical practice, and regulatory activities Kudos to all coauthors Francesco Malandrini Michela Meregaglia Massimo Di Maio Carmine Pinto Francesco De Lorenzo SDA Bocconi AIOM | Associazione Italiana di Oncologia Medica #FICOG #FAVO and Roche for the #PRO4ALL grant

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Chetoacidosi Diabetica Pediatrica: Riflessioni dalla Letteratura (Articolo Online ahead of print: Variations in Management and Clinical Outcomes for Children With Diabetic Ketoacidosis in an Academic Pediatric Versus Community Emergency Department Setting Freeman JN, et al. Pediatr Emerg Care. 2024 Apr) https://lnkd.in/dhisyPV2

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In the American Society of Clinical Oncology (ASCO) Educational Book we discuss key aspects of NSCLC in young adults - Marco Tagliamento Università degli Studi di Genova Laura Mezquita Matteo Lambertini #ASCO24 #LCSM #NSCLC #Cancer #OncoDaily #Oncology

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#EWAC2024: Advocating for the inclusion of integrative medicine and integrative oncology in European public healthcare systems is our continuous mission, stated Elisa Baldini, IVAA Secretary-General and EUROCAM Chair, in a recent EUROCAM webinar dedicated to the added value of Integrative Oncology in tackling cancer during #EWAC2024. ➡ Dr Tido von Schoen-Angerer, IVAA Vice President, played a crucial role in moderating the lively debate. He mentioned that some concrete steps forward had recently been made thanks to the new World Health Organization draft strategy for Traditional Medicine for the next ten years, which underlines the need for increasing investments in research to integrate Traditional, Complementary and Integrative Healthcare into the health system. ➡ Integrating traditional medicine into the health system is the future, believes Dr Eran Ben-Arye, director of the Unit of Complementary and Traditional Medicine at the Department of Family Medicine|Haifa. #AnthroposophicMedicine is one of the most important traditional modalities worldwide, especially in integrative oncology. ➡ A structural dialogue is crucial for the future of #IntegrativeMedicine, said Dr Jalid Sehouli, Deputy Director of the Charité Comprehensive Cancer Center (CCCC) at Berlin's Charité Hospital. He pointed to the immediate need to set up the framework for trans-professional and trans-disciplinary work and develop quality indicators for all complementary therapies. ➡ MEP Manuela Ripa considered it essential to raise awareness of the existing integrative treatments for cancer at the EU level, not just for patients but also within the medical world, and to guarantee patients' free access to the needed treatment. ℹ The online webinar "A new look into cancer care: The added value of Integrative Oncology" was co-organized by EUROCAM and Charité – Universitätsmedizin Berlin to mark the European Week Against Cancer 2024. #EWAC2024 #healthcare #cancer #IntegrativeMedicine

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𝐃𝐲𝐬𝐠𝐥𝐲𝐜𝐞𝐦𝐢𝐚, 𝐚 𝐩𝐫𝐞-𝐫𝐢𝐬𝐤 𝐟𝐚𝐜𝐭𝐨𝐫 𝐟𝐨𝐫 𝐜𝐚𝐫𝐝𝐢𝐨𝐯𝐚𝐬𝐜𝐮𝐥𝐚𝐫 𝐞𝐯𝐞𝐧𝐭𝐬 Our research center SAVE Studi Analisi Valutazioni Economiche has took part in a research on dysglycemia prevalence during World Diabetes Day 2018 and 2019 conducted by the Department of Internal Medicine and Therapeutics, University of Pavia, and IRCCS Policlinico San Matteo Foundation Hospital, Pavia, Italy 📊 It's well established that hypertension, hypercholesterolemia, and type 2 diabetes (T2DM) are main modifiable risk factors for cardiovascular diseases. Our study is aimed to identify the prevalence of dysglycemia in the general population and possibile reduction in costs trough prevention. 🔍 Key Takeaways: 📈 Prevalence of normo-glycemia: 61% 📉 Prevalence of dysglycemia: 28% 📉 Prevalence of diabetes: 11% 💡 Implications: Our findings suggest a lower prevalence of diabetes compared to national reported values. 🔹 High prevalence of dysglycemic subjects highlights the importance of incorporating screening and prevention strategies in order to generate economic savings. Let's continue raising awareness and working towards effective prevention strategies for a healthier future! 💪 𝐹𝑜𝑟 𝑟𝑒𝑎𝑑 𝑡ℎ𝑒 𝑎𝑟𝑡𝑖𝑐𝑙𝑒, 𝑐𝑙𝑖𝑐𝑘 𝑜𝑛 𝑡ℎ𝑖𝑠 𝑙𝑖𝑛𝑘:  https://lnkd.in/dKWBhWn8 Autori: Giuseppe Derosa, Pamela Maffioli, catherine klersy, Virginia V. Ferretti, Angela D’angelo, Sergio Di Matteo, Giacomo M. Bruno, Giorgio Lorenzo Colombo #WorldDiabetesDay #Research #Healthcare #CardiovascularHealth #Dysglycemia #dyslipidemia #prehypertension #prerisk #Prevention #PublicHealth #UniversityofPavia #SanMatteoHospital #DiabetesAwareness #HealthResearch #healtheconomy #health #savestudi If you want know anymore, write to: info@savestudi.it Università degli Studi di Pavia Fondazione I.R.C.C.S. Policlinico San Matteo Pavia, Chiara Martinotti, Maria Chiara Valentino, Giulia Vittoria Faitelli, Roberta Di Massa, Emidio Paniccia, Alessandro Alfano

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🌟Never miss this interesting #Review 🔥Article Views 2135; Citations 2 Title: Unveiling the Etiopathogenic Spectrum of Hypophysitis: A Narrative Review 👥Sara Menotti  et al. 🏥Pituitary Unit, Department of Endocrinology and Metabolism, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, Italy 🔗https://lnkd.in/gTByvqkS Journal of Personalized Medicine MDPI Figure 3. Etiopathogenesis of SARS-CoV-2 and vaccine-related hypophysitis

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Profiling exosomes for the early diagnosis of laryngeal cancer: in their latest work, Marco Bocchetti, Gabriella Misso at University of Campania "Luigi Vanvitelli" and collaborators sought to isolate and characterise exosomes derived from the serum of laryngeal cancer patients using flow cytometry, aiming to identify a specific epitope signature that could be used for early diagnosis https://lnkd.in/gXD2cPvv Their method could enable the development of a cost-effective and minimally invasive liquid biopsy protocol using a simple blood draw, facilitating early diagnosis of lung cancer and improving patient outcomes and quality of life. An article co-authored by Amalia L., Clara Iannarone, Lucia Stefania Pasquale, Michela Falco, Chiara Tammaro, marianna abate, Maria Grazia Ferraro, Raffaele Addeo, Filippo Ricciardiello, Giovanni Motta, Luca De Stefano, Francesco Caraglia, Anna Ceccarelli, Silvia Zappavigna, Marianna Scrima, Alessia Maria Cossu and Michele Caraglia #extracellularvesicles #exosomes #flowcytometry #biomarkers #diagnostic #Vesiculab

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We are glad to share our data gathered and analysed thanks to a fruitful collaboration between GiViTI - Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva, Istituto Mario Negri and Ospedale Luigi Sacco. Over the decade 2013-2022, Italian ICUs experienced a significant burden of HAIs, with a high prevalence of CR-GNB. This trend was mainly driven by Klebsiella spp. and Pseudomonas aeruginosa, with 31.4% and 21.8% of isolates showing this susceptibility profile, respectively. CR-GNB caused a third of all IAIs and a quarter of all VAP, BSI and UTI caused by these pathogens. During the SARS-CoV-2 pandemic, ICU HAIs showed a peak in both incidence and CR-GNB rates, in contrast to a previously declining trend. Read our full paper, available now on Frontiers in Microbiology Marta Colaneri Bruno Viaggi Andrea Gori Stefano Finazzi Alessandra Bandera Camilla Genovese Ospedale Policlinico di Milano

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New SGLT2 inhibitor meta-analysis on effect on HF- across diff populations  https://lnkd.in/e8b8KK7h

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First-ever images of structures linked to ADTKD, a rare chronic kidney disease (CKD). Researchers from the University of Campania "Luigi Vanvitelli" (Caserta, Italy), led by Dr. Davide Viggiano, with collaborators from the Sant'Anna e San Sebastiano Hospital (Caserta, Italy), investigated the structures found in urine by 4 patients with Autosomal Dominant Tubulointerstitial kidney disease (ADTKD). ADTKD is a rare, progressive chronic kidney disease. This paper marks the first time sediment from urine has been analyzed at the nanoscale level for this disease. The researchers found that the sediment contained wagon wheel structures at the microscale and rod-like structures at the nanoscale. We are thrilled that our nGauge AFM system was used to help develop understanding of this rare chronic kidney disease. The research was published in the journal Nephrology, Dialysis and Transplantation. Read the paper by following the link in the comments. Special thanks to our partners in Italy, Gian Luca Rovelli and Flavio Belvedere from ABCS Srl for their support. Note: The nGauge AFM is for research use only. #microscopy #atomicforcemicroscopy #AFM

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