Video Journal of Neurology (VJNeurology)

#NEW from #MDS2023 | The multifaceted nature of #Parkinson’s disease: potential treatment targets 🎥 🧠 Gennaro Pagano, MD, MSc, PhD, Roche Pharma Research & Early Development, discusses the multifaceted nature of #Parkinsonsdisease and the various factors contributing to its development and progression While #alphasynuclein is recognized as a key driver of the disease, #inflammation and dysfunctional #lysosomes also play a role. Targeting all these factors simultaneously could potentially help prevent the disease💡 Additionally, direct targeting of #microglia, which are activated by aggregated #proteins and #neuronal loss, is being explored as a strategy Find out more 👉 https://lnkd.in/etXJQ6fH #Neurology

Check out our NEW #podcast: #ALS #GeneTherapy Insights with Prof. Dame Pamela Shaw🎧 🧠 In recent years, #genetictherapies have garnered much attention for their potential to modify the underlying pathological processes in #neurologicaldiseases. By correcting, replacing, or removing aberrant #geneticmaterial, gene therapies could revolutionize the treatment of many diseases, where symptomatic management is the only available option 🧬 Examples of gene therapy methods include the use of #CRISPR/#Cas9 technologies to directly edit #geneticmutations, vector-based #genetherapy to deliver new genetic material, and antisense #oligonucleotides (ASOs) to modulate #geneexpression 🔦 In this podcast, we are joined by leading neurologist Prof. Dame Pamela Shaw who will share her insights into the progress in genetic therapies for #ALS and explain the challenges being faced, offering a glimpse into the future ALS therapy landscape Give it a listen 👉 https://ow.ly/Jkyi50SUELV Use the time codes to skip to your favourite part of each episode 👀 SUBSCRIBE so you don't miss any future episodes📱 #VJNeurology #Neurologynews

Check out our NEW #podcast: #ALS #GeneTherapy Insights with Prof. Dame Pamela Shaw🎧 🧠 In recent years, #genetictherapies have garnered much attention for their potential to modify the underlying pathological processes in #neurologicaldiseases. By correcting, replacing, or removing aberrant #geneticmaterial, gene therapies could revolutionize the treatment of many diseases, where symptomatic management is the only available option 🧬 Examples of gene therapy methods include the use of #CRISPR/#Cas9 technologies to directly edit #geneticmutations, vector-based #genetherapy to deliver new genetic material, and antisense #oligonucleotides (ASOs) to modulate #geneexpression 🔦 In this podcast, we are joined by leading neurologist Prof. Dame Pamela Shaw who will share her insights into the progress in genetic therapies for #ALS and explain the challenges being faced, offering a glimpse into the future ALS therapy landscape Give it a listen 👉 https://ow.ly/Jkyi50SUELV Use the time codes to skip to your favourite part of each episode 👀 SUBSCRIBE so you don't miss any future episodes📱 #VJNeurology #Neurologynews

NEW from #EAN2024 | #Opioid use in patients with #medication overuse #headache 🧠 🎥 Gisela Terwindt, MD, PhD, Leiden University, highlights the need to avoid #opioids as treatments for #headache, referring to the #opioid crisis in the USA as an example of the negative effects of opioid prescription 💊 🇺🇸 13% of migraine patients in the Netherlands have used #opioids, with some having used them preventatively, and 2% of those who have used #opioids had not been prescribed them Prof. Terwindt emphasizes that more education is needed about the effect of #opioids and more needs to be done to ensure these patients have preventative treatments and do not feel the need to turn to #opioids Find out more 👉 https://lnkd.in/emPHqWqB #Neurologynews #Neurology #EAN2024

NEW from #EAN2024 | Treating patients with long-term #neurological conditions 🧠 🎥 Katarina Rukavina, MD, PhD, King's College London & King's College Hospital NHS Foundation Trust discusses a survey of European #neurologists investigating the challenges in treating patients with long-term #neurological conditions, which are increasing in prevalence and emerging as a leading cause of #disability worldwide 🌍 🔦 Europe is particularly vulnerable due to its #aging population. Patients with long-term #neurological conditions experience complex and #refractory symptoms for the rest of their lives and often require hospitalization 🏥 To better understand the challenges involved in managing these conditions, over 150 #neurologists were surveyed. A majority expressed dissatisfaction with the #psychosocial and #spiritual support offered to patients when they experienced acute worsening Find out more 👉 https://ow.ly/8HHu50SOj8K #Neurologynews #Neurology #EAN2024

Fondazione Mondino - Istituto Neurologico Nazionale IRCCS Università di Pavia

Join us for our upcoming webinar series: ‘Advances in #Neurology’ 🧠 📣 🗓️ November 2024 📍 Virtual Webinar A series of live webinars focusing on key advances from 2024 in the diagnosis, treatment, and management of #neurologicaldisorders 🔦 Topics of discussion: 💡 Translating Novel #Diagnostics into Practice: Updates for #NeurodegenerativeDiseases 💡 Therapeutic Advances for #NeuromuscularDiseases  💡 Evolving Strategies in #Stroke Management  Agendas will be available closer to the time 📝 Register your interest NOW 👉 https://lnkd.in/e7mRwtan #Neurology #VJNeurology #Neurologywebinar #Neurologynews

The clinical profile of double-negative #NMOSD is poorly defined in the literature 📖 🧠 Antonio Malvaso, MD, IRCCS “C. Mondino” National Neurological Institute, University of Pavia, discusses the findings of his systematic review and meta-analysis, which aimed to characterize this condition 💡 The systematic review revealed a female to male ratio of 2:1 💡 A relapsing course was seen in 66%, versus monophasic course recorded in 33% 💡 From a clinical point of view, patients typically presented with isolated #opticneuritis, isolated #myelitis, or LETM 💡 Dr Malvaso highlights that MRI results revealed #MRI abnormalities in around two thirds of patients. Data from #cerebrospinalfluid (CSF) analysis demonstrated that patients had #pleocytosis and #oligoclonalbands at rates consistent with AQP4-positive #NMOSD Find out more 👉 https://ow.ly/bE3R50SOiA9 #EAN2024 #Neurologynews

At #EAN2024, we interviewed Raffaele Dubbioso, MD, PhD, Università degli Studi di Napoli Federico II (UniNa) / University of Naples Federico II II, who highlighted the potential use of skin innervation as a non-invasive #prognostic #biomarker in #ALS! 🙌 🧠 🎥 #ALS has long been described as #motorneurondisease, but more recently, numerous non-motor symptoms have been recognized💡 🌟 These include #cognitive and #autonomic symptoms, as well as #sensory involvement. Using the Small Fiber Neuropathy Symptoms Inventory Questionnaire (SFN-SIQ), it was found that around 35% of ALS patients report sensory symptoms 🌟 Small-fibre sensory disturbances like burning pain were the most frequent. Skin biopsies showed large sensory denervation, with different patterns depending on the stage of disease 🌟 In patients with later stage disease, profound loss of #Meissner’s corpuscle density was found, however, a regeneration pattern was found in intraepidermal nerve fibres. Patients with more aggressive disease showed higher regeneration Dr Dubbioso highlights the potential use of skin innervation as a non-invasive prognostic #biomarker Find out more 👉 https://ow.ly/afhy50SIhJF #Neurology