One of the most popular regions in Italy, Tuscany stretches from the Tyrrhenian Sea to the Apennines. Its main cities include Florence, Pisa, Siena, Lucca, Arezzo and Livorno. Drive between stunning sites like Florence's cathedral and Uffizi Gallery and the Leaning Tower of Pisa. Or join a bike tour and pedal past sun-baked olive groves and vineyards. Don't miss the towers of San Gimignano or serene northern hill towns. For a more modern take, hit one of Florence's hip clubs, such as Space Electronic.

You'll find rugged beauty and a slow pace in the Cinque Terre. Named for the five towns of Monterosso, Vernazza, Corniglia, Manarola and Riomaggiore, this portion of the Italian Riviera is a UNESCO World Heritage Site. Cars aren't allowed, so take local trains or ferries to go from town to town—or walk one of the spectacular trails that connect them.

Relics ranging from ancient shrines to Venetian-style castles overlook swaths of golden sand beaches on Kos, a fertile island in Greece’s Dodecanese chain. Mega-resorts dominate the developed southern coast, while visitors looking for tranquility head to the quieter northern shores.

Centrally located Umbria's principal cities include Spoleto, Assisi, and Terni. The capital, Perugia, is famed for its chocolate. Take a tour bus or prepare for daredevil Italian drivers if you opt to rent a car. Assisi's Basilica has a host of treasures, including works by Giotto. The town is also home to the crypt of St. Clare, patron saint of television. St. Francis' meditation retreat is in the mountains to the north. Classes at Velia's Cooking Style in Terni make good use of local produce.

Butterfly-shaped Favignana is a lovely destination for divers and beach lovers. Climb aboard the adorable Egadilandia, a tourist train that chugs along the island’s main streets and coastlines. Don’t miss the Ex Stabilimento Florio (a tuna canning factory turned museum), the challenging hike to the hilltop ruins of the Castello di Santa Caterina and snuggling up with your soul mate at the Lover’s Grotto.

Glamourous Santorini is deliciously different. Geographical newness is in part to thank. The island’s popular black volcanic Perissa and Kamari beaches are big draws, as is its arguably most famous Red Beach near Akrotiri (which is the place to go for archaeology buffs). Santorini curves round a giant lagoon in the Cyclades islands, offering stunning views from sky-high towns, eclectic cuisine, lovely galleries, thriving nightlife and excellent wines.

From the silvery crests of the Alps to the sparkling Mediterranean Sea, Italy’s beauty is unparalleled. A visit could mean marveling at the Colosseum after a tender plate of pasta, or drifting lazily down a canal, your belly full of local Sangiovese. Explore Tuscan vineyards and olive groves or drool over boutiques in fashionable Milan. Look for mermaids from the cliffs of Sorrento or nibble on Parma’s famous cheese and prosciutto. Anywhere you choose, the country will captivate you.

Provence, in southeastern France, is divided into six departments and stretches from Orange to Nice. Many consider the Luberon in Vaucluse to be the "real Provence". Gently sloping vineyards and lavender fields are the backdrops that enthralled Cezanne, Van Gogh and Chagall. An excellent train network makes travel between towns easy. To explore villages, drive or catch a bus. Highlights include the Palace of the Popes at Avignon, the Roman amphitheatre at Arles and the craft centre of Les Baux.

There's much more to France than Paris—from the fairy-tale châteaux of the Loire Valley to the lavender fields of Provence, and the French Riviera's celebrity-studded beaches. World-famous gastronomy and fine wines provide the perfect complement to the country's alpine views and architectural masterpieces.

"For simple beauty, Cape Breton outrivals them all." So said Alexander Graham Bell of the island he adopted as his home. Rich with Celtic, Mi'kmaq and Acadian heritage, Cape Breton is a delight for history buffs, music lovers and explorers of nature. Immerse yourself in 18th-century life at the Fortress of Louisbourg, explore the winding roads and Atlantic vistas of the Cabot Trail, and seek out a local Ceilidh for a lively and rousing experience.

One of the three principal islands of the Maltese archipelago, the island of Malta is the largest of the chain. Its capital Valletta, a lively, bustling city with many buildings dating back to the 16th century, teems with cathedrals, palaces and forts. The impressive Grand Harbour offers a dramatic arrival. The top archaeological attraction is the UNESCO-designated Hypogeum temple ruins, a macabre, 5400-square-foot underground necropolis and the world's only underground prehistoric temple.

Tiny Skiathos is packed with pine forests, archaeological ruins, and—most importantly—beaches. Shed your inhibitions at the nudist Banana Beach or have a more modest sun session at Koukounaries, which is peppered with lively cafes. Sail around on a chartered catamaran, hike to the dramatic medieval ruins of Kastro and tap into your spiritual side at one of Skiathos many monasteries.