One of the most popular regions in Italy, Tuscany stretches from the Tyrrhenian Sea to the Apennines. Its main cities include Florence, Pisa, Siena, Lucca, Arezzo and Livorno. Drive between stunning sites like Florence's cathedral and Uffizi Gallery and the Leaning Tower of Pisa. Or join a bike tour and pedal past sun-baked olive groves and vineyards. Don't miss the towers of San Gimignano or serene northern hill towns. For a more modern take, hit one of Florence's hip clubs, such as Space Electronic.

The Mediterranean's biggest island is separated from the mainland by the Strait of Messina. A mountainous spot, Sicily's coast and its small islands sit at the foot of volcanoes, including Etna, Stromboli and Vulcano. The Greeks, Romans, Normans and Catalans all left their mark on the island in the form of Byzantine palaces, Gothic castles and Baroque flourishes in capital Palermo. Most larger towns offer interesting museums, but Etna and the Hellenic temples in Agrigento offer particularly unique sights.

There are beaches for everyone on Paros—families, partiers, watersports enthusiasts, honeymooners. Anyone can find their perfect stretch of golden sand. The same breeze that rustles orange and pomegranate trees will power your kitesurfing or windsurfing session. In the capital city of Parikia, make sure to pay your respects at the Byzantine “church of 100 doors” (Panagia Ekatontapillani) and visit the seaside ruins of a medieval castle built from the marble remains of an ancient temple.

From sun-drenched archipelagos and bustling urban cities to snowcapped mountains and semi-arid deserts, Spain epitomizes geographical diversity. As the meeting point of the Atlantic Ocean and Mediterranean Sea, this vast country offers some of Europe’s most dramatic landscapes, as well as some of its tastiest cuisine.

Woven with wild greenery and Gaelic legends, the Emerald Isle is one of Europe’s most prized jewels. Rugged Atlantic beaches and mystery-shrouded sites rub shoulders with the cosmopolitan cities of Belfast and Dublin, where literary history and warm Irish hospitality are always in abundance.

There's much more to France than Paris—from the fairy-tale châteaux of the Loire Valley to the lavender fields of Provence, and the French Riviera's celebrity-studded beaches. World-famous gastronomy and fine wines provide the perfect complement to the country's alpine views and architectural masterpieces.

The jungles and monsoon forests of Vietnam are diverse ecosystems that are alive with unique wildlife. Trekking is a popular activity here, particularly the mountains of Sapa and the primeval landscape of Cuc Phuong National Park. For a more urban escape, take a guided food tour of Ho Chi Minh City, making sure to squeeze in visits to the historic Hoi Truong Thong Nhat palace and the intricately adorned Emperor Jade Pagoda.

East meets West in this sun-soaked state, where Indian culture intertwines with Portuguese influences left over from a 500-year occupation. The beaches have long served as a magnet for serene hedonists. To the north, the tourist-centric scene is prevalent, with an international flair that is now skewing more hip than hippie. Travel south for stretches of unspoiled sand and an escape from large resorts. Temples, mosques and wildlife sanctuaries provide diversions from the beach.

Portugal’s Mediterranean charm is most prominent on the golden beaches of the Algarve; in the wilderness of the Azores islands; among the vineyards of Douro Valley; and on the cobbled streets of Lisbon and Porto, where old-world culture meets cosmopolitan bars and restaurants.

Relics ranging from ancient shrines to Venetian-style castles overlook swaths of golden sand beaches on Kos, a fertile island in Greece’s Dodecanese chain. Mega-resorts dominate the developed southern coast, while visitors looking for tranquility head to the quieter northern shores.