We won't lie: Niagara Falls is uber-touristy. There are wax museums and a Ripley's Believe It or Not Museum, and if it's a fast-food chain, you can probably find it here. But even the most jaded hipster shouldn't pass up a chance to visit this town, because the Falls themselves are spectacular.

Buffalo is being reborn as a mecca for art, architecture, history, culture, dining and entertainment. Experience Frank Lloyd Wright’s stunning Darwin Martin House Complex and world-class modern art at the Albright-Knox Art Gallery. Relive part of the city’s incredible history at the Theodore Roosevelt Inaugural National Historic Site. Explore the emerging Canalside waterfront district, hip Elmwood Village, more than 400 independently owned restaurants (serving our famous chicken wings and more) and nearby Niagara Falls.

We've heard Toronto described as "New York City run by the Swiss," and it's true—you can find world-class theatre, shopping and restaurants here, but the sidewalks are clean and the people are friendly. The best place to start is literally at the top—the CN Tower, the tallest freestanding structure in the Western Hemisphere.

Toronto's neighbour Mississauga has more than 480 parks and woodlands for you to explore. Stroll the Waterfront Trail, rent a boat at the marina or spend a day at the racetrack. It's also called Ontario's shopping capital, with everything from shopping centres and outlet malls to picturesque village-style shopping streets.

The next time you're driving to Toronto or Niagara Falls, stop in Hamilton, where tourist traffic isn't quite so rampant. The Niagara Escarpment provides spectacular scenery, with beautiful trails and waterfalls. Visit nearby farms, orchards and vineyards, or plan your trip to coincide with Hamilton's lively fall fairs.

Whether you love sailing, touring wineries, or exploring Amish country, this picturesque region has something for everyone. In summer, Chautauqua County lures you with its five lakes including the Lake Erie shoreline, as well as dynamic arts and cultural programming at the Chautauqua Institution. In winter, abundant snows make it perfect for alpine and cross-country skiers. Any time of year, visit Jamestown and discover tributes to Lucille Ball, Roger Tory Peterson, and Robert H. Jackson.

Ottawa is a compact, clean, cleverly planned centre of culture and politics. And it's an ideal choice for a weekend getaway. Start downtown at the architecturally stunning National Gallery of Canada, and don't miss the Canadian Nature Museum and the National Aviation Museum. Rideau Canal offers boating in the summer and ice-skating in the winter. Gatineau Park attracts cyclists and walkers, while Byward Market blends old and new Ottawa.

As North America’s northernmost large metropolis, Edmonton is a fascinating study in contrasts — a vibrant urban centre in the heart of the wilderness. It’s a city that’s never been afraid to do things a little differently, as visitors discover through close encounters with free-roaming bison, a shopping mall that spans more than 48 city blocks, and a dynamic arts and culture scene that embraces more than 40 annual festivals, including the continent’s biggest and wildest Fringe Theatre Festival.