Tamas Sohajda’s Post

today's #cyclodextrin: Is a nice example of how to use CDs (in this particular case HPBCD) in peptide/protein formulations. ELGAN Pharma's patent is about combining #insulin, cyclodextrins and other components where the role of the CD is stabilization and cryopreservation. As we see more and more examples in research and clinical practice for CD-protein combinations, I am convinced that this use will shape future applications.

Here is another success story of using cyclodextrins as active ingredients. Read the story of Marcelo Nociari and reVision Therapeutics, Inc. developing a cyclodextrin in ophthalmology for the therapy of Stargardt's disease. #raredisease #ocular #ophthalmics

Over the weekend I just realized that I earned several Community Top Voice Badges on Linkedin in these categories via actively contributing to collaborative articles: - Research and Development - Research Skills - Entrepreneurship LinkedIn collaborative articles are a way to tap into the collective knowledge of the LinkedIn community. These articles cover professional topics, ranging from common questions like “How do I get a promotion?” to more specific inquiries like “How do I advertise to Generation Z?” Initially, they start as AI-powered conversation starters developed by LinkedIn’s editorial team, but they become richer with insights from community members. A select group of experts also contribute their own ideas, examples, and experiences within these articles. Contributing to collaborative articles can broaden your reach, help you grow a following, and build a reputation on LinkedIn. Additionally, if you’re one of the most upvoted contributors for a particular skill, you can earn a Community Top Voices badge. So, dive in, share your expertise, and watch your professional network flourish!

Who is in for a Chem-Chess battle?

The 9 Greenest Flags of company culture? One question I’ve found that has come up a lot for me recently is “How do I know my workplace has a strong culture?” Or “How do I know the new company I have applied for has a culture for me?”  I’ve compiled a list of my top 9 company culture green flags. If you’re company has these, it’s a very high chance they have a brilliant culture. 1. Clear Vision - Everyone is aligned on the same mission. 2. Embraces Failure - “Family” culture is toxic. The best culture is driven by performance. 3. Values Your Time - Will not overkill you with pointless meetings. 4. Shows Empathy - Treats everyone with respect & empathy no matter what. 5. Adapts to Change - Embraces change and can adapt to it fast. 6. Open Communication - Communication is 2 ways and clear across the levels of hierarchy. 7. Corrects Bad Behaviour - Bad behaviour is not tolerated and if it occurs it will be corrected fast. 8. Empowers Hard Work - Hard work is consistently rewarded. Encourages the team to go the extra mile. 9. Performance Driven - Employees are encouraged to see failure as an opportunity to learn. What works best at your place? Follow Tamas Sohajda and SciConn for more!

Today's #cyclodextrin paper by CarboHyde CSO Milo Malanga PhD, in collaboration with former colleagues from Cyclolab R&D Ltd. and Budapest University of Technology and Economics, sheds light on the potential of cyclodextrins in inhibiting bacterial communication through quorum sensing. Quorum sensing is vital for bacteria to coordinate activities, but inhibiting this process can be a game-changer in combating bacterial infectivity. Cyclodextrins encapsulate signal molecules, disrupting bacterial communication and, consequently, the expression of virulence factors. Excitingly, our research shows that cyclodextrins exhibit a notable inhibitory effect on the quorum-sensing system of A. fischeri. The impact varies with alkyl chain length, with alkylthio substitution amplifying inhibition and quaternary ammonium groups mitigating it. These findings highlight cyclodextrins' potential as a promising therapeutic avenue for bacterial infection treatment. https://lnkd.in/dB5tKrJN

How to create infographics for science? Infographics are where information and illustration meet; the challenge lies in combining the two effectively. It’s easy to pair images with text, but it’s harder to do this in a meaningful way that tells an engaging story while keeping things accurate and succinct.

today's #cyclodextrin: this recent patent of RemeGen Biosciences suggests that cyclodextrins, particularly methyl-beta-cyclodextrin (https://lnkd.in/gUP84SCk) can significantly improve the efficacy of antibody-drug conjugates so that some of the ADC drugs with safety issues caused by excessive dosage can be developed. Moreover, due to the reduction in the dosage of ADC drugs, the cost of production and the cost of treatment for patients have also been greatly reduced, thereby being beneficial. https://lnkd.in/g8nwxp-K

Learn more about how the success story of using cyclodextrins as active ingredients started with a great idea in 1983 that led to a life-saving therapy and a few years later to a blockbuster drug and orphan treatments

today's #cyclodextrin is this great patent from Roquette's team, Tao Peng Lucas Goh, Jeff Chang Shih Chieh on a new class of Lipid nanoparticles (LNPs) that can be used for nucleic acid delivery, wherein LNPs comprise a nucleic acid and a nonionic or cationic cyclodextrin compound. How do you see the future of CDs in gene therapy? Will we see solutions commercialized in the future? In GENEGUT we certainly work towards this goal! #genetherapy #drugdelivery #nucleicacid #oligonucleotide