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Articles by Tamas
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How to create an engaging video clip for TikTok
How to create an engaging video clip for TikTok
By Tamas Sohajda
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HOW TO PRODUCE TOP-NOTCH SCIENCE YOUTUBE VIDEOS
HOW TO PRODUCE TOP-NOTCH SCIENCE YOUTUBE VIDEOS
By Tamas Sohajda
Contributions
Activity
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Yes, this is hilarious, but let's aim for better in academia. Here's a roadmap for improvement: - Undergraduates: Engage in real research projects…
Yes, this is hilarious, but let's aim for better in academia. Here's a roadmap for improvement: - Undergraduates: Engage in real research projects…
Shared by Tamas Sohajda
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Struggling with endless to-do lists and conflicting tasks? It’s time to transform your approach with these powerful strategies: 1️⃣ Eisenhower…
Struggling with endless to-do lists and conflicting tasks? It’s time to transform your approach with these powerful strategies: 1️⃣ Eisenhower…
Liked by Tamas Sohajda
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Hello Comunnity, This is me analyzing samples in FTIR. This technique allows the identification of functional groups and can be used to characterize…
Hello Comunnity, This is me analyzing samples in FTIR. This technique allows the identification of functional groups and can be used to characterize…
Liked by Tamas Sohajda
Experience & Education
Publications
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Synthesis of modified cyclic and acyclic dextrins and comparison of their complexation ability
Beilstein J. Org. Chem. 2014, 10, 2836–2843; DOI: 10.3762/bjoc.10.301
Abstract
We compared the complex forming ability of α-, β- and γ-cyclodextrins (α-CD, β-CD and γ-CD) with their open ring analogs. In addition to the native cyclodextrins also modified cyclodextrins and the corresponding maltooligomers, functionalized with neutral 2-hydroxypropyl moieties, were synthesized. A new synthetic route was worked out via bromination, benzylation, deacetylation and debenzylation to obtain the 2-hydroxypropyl maltooligomer counterparts. The complexation…Abstract
We compared the complex forming ability of α-, β- and γ-cyclodextrins (α-CD, β-CD and γ-CD) with their open ring analogs. In addition to the native cyclodextrins also modified cyclodextrins and the corresponding maltooligomers, functionalized with neutral 2-hydroxypropyl moieties, were synthesized. A new synthetic route was worked out via bromination, benzylation, deacetylation and debenzylation to obtain the 2-hydroxypropyl maltooligomer counterparts. The complexation properties of non-modified and modified cyclic and acyclic dextrins were studied and compared by photon correlation spectroscopy (PCS) and capillary electrophoresis (CE) using model guest compounds. In some cases cyclodextrins and their open-ring analogs (acyclodextrins) show similar complexation abilities, while with other guests considerably different behavior was observed depending on the molecular dimensions and chemical characteristics of the guests. This was explained by the enhanced flexibility of the non-closed rings. Even the signs of enantiorecognition were observed for the chloropheniramine/hydroxypropyl maltohexaose system. Further studies are planned to help the deeper understanding of the interactions.Other authorsSee publication -
Synthetic strategies for the fluorescent labeling of epichlorohydrin-branched cyclodextrin polymers
Beilstein J. Org. Chem. 2014, 10, 3007–3018; doi:10.3762/bjoc.10.319
Abstract
The fluorescent tagging of cyclodextrin derivatives enlarges their spectroscopic properties thus generating chemosensors, biological tools for visualization and sophisticated photoresponsive devices. Cyclodextrin polymers, due to the cooperative interactions, exhibit additional properties compared to their monomeric counterpart. These macromolecules can be prepared either in well water-soluble form or as gels of high swelling. Two versatile synthetic strategies for introducing a…Abstract
The fluorescent tagging of cyclodextrin derivatives enlarges their spectroscopic properties thus generating chemosensors, biological tools for visualization and sophisticated photoresponsive devices. Cyclodextrin polymers, due to the cooperative interactions, exhibit additional properties compared to their monomeric counterpart. These macromolecules can be prepared either in well water-soluble form or as gels of high swelling. Two versatile synthetic strategies for introducing a fluorescent tag (rhodamine, fluorescein, nitrobenzofuran or coumarin) into the water-soluble epichlorohydrin branched cyclodextrin polymers were worked out and compared. The fluorescent labeling was realized in three steps: 1) building in azido moieties, 2) transforming the azido groups into amino groups and 3) coupling the proper fluorescent compound to the amino groups. The other strategy started by functionalization of the monomer prior to the branching. Either the fluorescent-labeled monomer or the intermediate azido derivative of the monomer was branched. Further tuning of the properties of the polymer was achieved via branching of the methylated cyclodextrin derivative. The key intermediates and the fluorescent final products were characterized by various spectroscopic techniques and capillary electrophoresis. The applied synthetic routes were evaluated based on the molecular weight, cyclodextrin content of the products and the efficiency of labeling.Other authorsSee publication -
Chiral recognition of dapoxetine enantiomers with methylated-gamma-cyclodextrin: A validated capillary electrophoresis method
Journal of Pharmaceutical and Biomedical Analysis
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Separation and characterization of modified pregabalins in terms of cyclodextrin complexation, using capillary electrophoresis and nuclear magnetic resonance
Journal of Pharmaceutical and Biomedical Analysis
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Separation of vinca alkaloid enantiomers by capillary electrophoresis applying cyclodextrin derivatives and characterization of cyclodextrin complexes by nuclear magnetic resonance spectroscopy
Journal of Pharmaceutical and Biomedical Analysis
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Characterization of aspartame–cyclodextrin complexation
Journal of Pharmaceutical and Biomedical Analysis
Languages
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English
Full professional proficiency
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German
Limited working proficiency
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Hungarian
Native or bilingual proficiency
More activity by Tamas
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Managers influence 70% of employee engagement and overall mood (According to Gallup). Here are 10 ways they can make an impact: 1/ Clear…
Managers influence 70% of employee engagement and overall mood (According to Gallup). Here are 10 ways they can make an impact: 1/ Clear…
Liked by Tamas Sohajda
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How to Manage Stress. The Complete Guide for Stress Management: A fantastic cheatsheet by Josh S. 🔥 Work-related stress leads to: A staggering…
How to Manage Stress. The Complete Guide for Stress Management: A fantastic cheatsheet by Josh S. 🔥 Work-related stress leads to: A staggering…
Liked by Tamas Sohajda
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Warmly welcome the representative of Indonesia Gold Mining to visit our company, our business lunch went very well and it will be a pleasant…
Warmly welcome the representative of Indonesia Gold Mining to visit our company, our business lunch went very well and it will be a pleasant…
Liked by Tamas Sohajda
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Excited that today in Nature our collaboration with Manolis Kellis and David Bennett has published an analysis of scRNAseq data from more than 1.3…
Excited that today in Nature our collaboration with Manolis Kellis and David Bennett has published an analysis of scRNAseq data from more than 1.3…
Liked by Tamas Sohajda
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We are very excited to welcome Mike Gilbert, who joined Barentz Pharma North America team as Vice President of Sales for USA and Canada. With over…
We are very excited to welcome Mike Gilbert, who joined Barentz Pharma North America team as Vice President of Sales for USA and Canada. With over…
Liked by Tamas Sohajda
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One year ago, ADL BioPharma, as one of the largest #biotech facilities in Europe, became part of WACKER! As your trusted partner for CMO services…
One year ago, ADL BioPharma, as one of the largest #biotech facilities in Europe, became part of WACKER! As your trusted partner for CMO services…
Liked by Tamas Sohajda
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Why You Need to Look Out for Transition Metal Degradation In my last post about forced degradation studies, I mentioned stress testing by transition…
Why You Need to Look Out for Transition Metal Degradation In my last post about forced degradation studies, I mentioned stress testing by transition…
Liked by Tamas Sohajda
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Did you know that cyclodextrins can be active ingredients as well as excipients? https://lnkd.in/d_NM8T3K
Did you know that cyclodextrins can be active ingredients as well as excipients? https://lnkd.in/d_NM8T3K
Liked by Tamas Sohajda
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