Tamas Sohajda’s Post

#healthresearchatHFIPS The isolation and enrichment efficiency of SARS-CoV-2 virus in complex biological environments is often relatively low, presenting challenges in direct detection and an increased risk of false negatives, particularly during the early stages of infection. To address this issue, HFIPS researchers have developed a novel approach using ultrasmall magnetosome-like nanoparticles (≤10 nm) synthesized via biomimetic mineralization of the Mms6 protein derived from magnetotactic bacteria. Know more: https://lnkd.in/gbZz4rwB

🔎 Let’s take a look at the ESKAPE pathogens – an acronym for the top six antibiotic resistant bacteria: • Enterococcus faecium • Staphylococcus aureus • Klebsiella pneumoniae • Acinetobacter baumannii • Pseudomonas aeruginosa • Enterobacter spp These are highly virulent bacteria for which we desperately need new treatments. 💊 Phage therapy has shown great promise in targeting these pathogens and could be a crucial tool in the fight against AMR. 📚 Click through the slides to learn more. #PhageTherapy #Science #AMR #Bacteriophage #ESKAPE

Coupling host bacterium sequence analysis with host range data for 70 phages, we observed a correlation between existing phage resistance and the presence of higher numbers of antiphage systems in bacterial genomes. We were also able to identify antiphage systems that were more prevalent in highly phage-resistant P. aeruginosa strains, suggesting their importance in conferring resistance. Stephanie Lesage Philip Mitchelmore Ben Temperton https://lnkd.in/gVpDr7Bg

I am excited to announce that our latest article, "Replication of Human Norovirus in Human Intestinal Enteroids Is Affected by Fecal Sample Processing" is now available in the journal Viruses! Our research reveals intriguing insights into successful Human Norovirus replication in Human Intestinal Enteroids (HIEs) and sheds light on factors affecting virus replication dynamics. Many thanks to my co-author and PhD advisor, Malak A. Esseili, PhD. , for her invaluable contributions to this study. And a big thank you to everyone involved in this research endeavor. Read the full article here for more information on #HumanNorovirus #IntestinalEnteroids and #VirusReplication: https://lnkd.in/eyH_9-gq

Bdellovibrio bacteriovorus uses chimeric fibre proteins to recognize and invade a broad range of bacterial hosts Nature https://lnkd.in/g8AbDR6t

Today is #WorldSepsisDay, and we're helping to raise awareness by shining a light on some of the extraordinary science of proteomics researchers! Iulia Macavei, from the Institute of Analytical Sciences in France, is using cutting-edge mass spectrometry techniques to investigate antimicrobial resistance in pathogens. Her goal? To develop a rapid method that can identify pathogens and their antibiotic resistance in under an hour, potentially saving countless lives by preventing sepsis. Watch this on-demand webinar to learn more 👉 https://bit.ly/3sRCeNR #Proteomics #AntibioticResistance #MassSpectrometry #ExtraordinaryScience

【Effect of a Thermal Spring Water on Carbohydrate-Protein Interactions in In-Vitro Models Implicating Normal Human Keratinocytes and Recombinant Lectins】 Full article: https://lnkd.in/gw_VwszX (Authored by Benoît Roubinet, et al., from GLYcoDiag (France), etc.) Lectins are ubiquitous proteins found within numerous plant and animal tissues and organisms and are of a great importance, notably in immune response involving bacteria, viruses and fungi. This study analyzes the effect of the thermal spring water (TSW) on the ability of #lectins naturally occurring at the surface of normal human keratinocytes (#NHK) to bind glycan and focuses on calcium-dependent type lectin receptors (CLRs) in an acellular model using human recombinant lectins (dectin-1 and langerin) by studying the effect of increasing concentrations of the TSW on the ability of these lectins to bind their specific ligands. #Immune_System

Harnessing UV-C Light: Understanding the Mechanism Behind Microbial Destruction Leveraging the power of ultraviolet light, UV-C disinfection offers an efficient and chemical-free method to eradicate pathogens. But how exactly do these wavelengths of light work to destroy organisms? 🔬 The Science of UV-C Light UV-C light operates in the ultraviolet spectrum, specifically within the 200-280 nanometer range. This wavelength is particularly effective at penetrating the cell walls of microorganisms, including bacteria, viruses, and fungi. 🛡 DNA and RNA Disruption When UV-C light strikes a microorganism, it penetrates the cell and is absorbed by the DNA and RNA. This absorption leads to the formation of thymine dimers, which are covalent bonds between adjacent thymine molecules in the DNA strand. These abnormal bonds disrupt the DNA's structure, preventing it from replicating correctly. ⚠️ Impact on Microbial Function With their genetic material damaged, microorganisms lose their ability to replicate and function. This effectively inactivates the pathogens, rendering them unable to cause infection or disease. #InfectionPrevention #UVCDisinfection #Microbiology #Healthcare #PatientSafety #InfectionControl

💡Our new study is out: Perfluorooctane Sulfonamide Induced Autotoxic Effects on the Zebrafish Immune System in Environmental Science & Technology 🐟🐟🐟 https://lnkd.in/dMEngSVh This study investigated the immunomodulatory effects of #PFOSA and #PFOS in zebrafish. PFOSA exposure compromised the zebrafish’s ability to fend off infections, increasing bacterial 🦠adhesion and decreasing levels of the protective protein lysozyme. It also disrupted inflammatory markers, immune indicators, and reduced immune cell counts. PFOSA’s immunotoxicity primarily stems from its own toxicity rather than its metabolite PFOS, supported by dose-dependent responses and NF-κB pathway analysis.

🔬 Exciting News! Our Latest Synthesized Compound Shows Promising Antibacterial Activity! I'm thrilled to share that our recent research endeavors have yielded promising results in the fight against bacterial infections! Through meticulous experimentation and the implementation of the well diffusion method, we assessed the antibacterial efficacy of our newly synthesized compound against four notorious bacterial strains. The outcomes were nothing short of remarkable! Our compound demonstrated significant antibacterial activity, as evidenced by clear zones of inhibition around the wells. This indicates the compound's ability to impede the growth of the tested bacterial strains effectively. #AntibacterialResearch #ScientificInnovation #HealthcareRevolution