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NADPH Oxidase in Pancreatic β-Cell Function
Purpose of ReviewThis review outlines NADPH oxidase structure and function in pancreatic β-cells. Furthermore, methods for detecting reactive oxygen...
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Structure of human phagocyte NADPH oxidase in the activated state
Phagocyte NADPH oxidase, a protein complex with a core made up of NOX2 and p22 subunits, is responsible for transferring electrons from intracellular...
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p47phox and NOXO1, the Organizer Subunits of the NADPH Oxidase 2 (Nox2) and NADPH Oxidase 1 (Nox1)
The enzyme responsible for superoxide anion production in phagocytes is called the phagocyte NADPH oxidase. It is a multicomponent enzyme system...
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NADPH Oxidase-Dependent Processes in the Social Amoeba Dictyostelium discoideum
Dictyostelium discoideum, also known as social amoeba, is at the boundary between unicellular and multicellular life. This protist is a professional...
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The NADPH Oxidase Activator p67phox and Its Related Proteins
The Nox family NADPH oxidases can be divided into two groups based on the presence or absence of the Ca2+-binding EF-hand motif in the N-terminal...
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NADPH oxidase contributes to the production of reactive oxygen species in Chlorella pyrenoidosa
Reactive Oxygen Species (ROS) play an important role in oxidative stress and are related to the lipid accumulation in microalgae. Nicotinamide...
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Low dose radiation upregulates Ras/p38 and NADPH oxidase in mouse colon two months after exposure
BackgroundExposure to ionizing is known to cause persistent cellular oxidative stress and NADPH oxidase (Nox) is a major source of cellular oxidant...
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Multifunctional regulation of NADPH oxidase in growth, microsclerotia formation and virulence in Metarhizium rileyi
ObjectivesMicrosclerotia (MS), anti-stress structures produced by many filamentous fungi, have been proven to be a great substitute for conidia in...
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NADPH oxidase 4-mediating oxidative stress contributes to endometriosis
NADPH oxidase 4 (NOX4) plays an important role in the regulation of oxidative stress, which is associated with endometriosis. This study aims to...
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Structure, regulation, and physiological functions of NADPH oxidase 5 (NOX5)
NOX5 is the last member of the NADPH oxidase (NOXs) family to be identified and presents some specific characteristics differing from the rest of the...
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Comprehensive analysis and identification of prognostic biomarkers and immunotherapeutic targets in the NADPH oxidase family (and its regulatory subunits) in pancreatic ductal adenocarcinoma
PurposeThis study aimed to evaluate the role of NADPH in pancreatic ductal adenocarcinoma using bioinformatic analyses and experimental validations.
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NADPH Oxidase 1: At the Interface of the Intestinal Epithelium and Gut Microbiota
NOX1 was the first of the NOX family of NADPH oxidases described with sequence homologous to the well-known microbicidal NADPH oxidase of phagocytes....
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Acid sphingomyelinase promotes diabetic cardiomyopathy via NADPH oxidase 4 mediated apoptosis
BackgroundIncreased acid sphingomyelinase (ASMase) activity is associated with insulin resistance and cardiac dysfunction. However, the effects of...
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Mitochondrial Dysfunction Contributes To Zinc-induced Neurodegeneration: a Link with NADPH Oxidase
Mitochondrial dysfunction and nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) are the major sources of augmentation in free...
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Physiological Functions and Pathological Significance of NADPH Oxidase 3
NADPH oxidase 3 (NOX3) is the catalytic subunit of a superoxide-producing enzyme complex in the inner ear. Other subunits of this complex include...
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Nifuroxazide attenuates indomethacin-induced renal injury by upregulating Nrf2/HO-1 and cytoglobin and suppressing NADPH-oxidase, NF-κB, and JAK-1/STAT3 signals
Indomethacin (INDO) is an NSAID with remarkable efficacy and widespread utilization for alleviating pain. Nevertheless, renal function impairment is...
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NADPH oxidase 2 mediates cardiac sympathetic denervation and myocyte autophagy, resulting in cardiac atrophy and dysfunction in doxorubicin-induced cardiomyopathy
Doxorubicin has been used extensively as a potent anticancer agent, but its clinical use is limited by its cardiotoxicity. However, the underlying...
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Structure of the core human NADPH oxidase NOX2
NOX2 is the prototypical member of the NADPH oxidase NOX superfamily and produces superoxide (O 2 •− ), a key reactive oxygen species (ROS) that is...
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NADPH oxidase family proteins: signaling dynamics to disease management
Reactive oxygen species (ROS) are pervasive signaling molecules in biological systems. In humans, a lack of ROS causes chronic and extreme bacterial...
