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Lung-on-a-Chip Models of the Lung Parenchyma
Since the publication of the first lung-on-a-chip in 2010, research has made tremendous progress in mimicking the cellular environment of healthy and...
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A distal lung organoid model to study interstitial lung disease, viral infection and human lung development
Organoids have been an exciting advancement in stem cell research. Here we describe a strategy for directed differentiation of human pluripotent stem...
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Mechanics of Lung Development
We summarize how skeletal muscle and lung developmental biology fields have been bridged to benefit from mouse genetic engineering technologies and...
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Engineering Translational Models of Lung Homeostasis and Disease
Cutting-edge engineering approaches towards modelling lung homeostasis and disease have created dynamic new opportunities for interdisciplinary...
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Introduction to Lung Disease
There has been a rise in the number of documented instances of lung illness in both children and adults around the globe. Both the morbidity and...
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Epigenetics of Lung Cancer
Lung cancer is the biggest cause of cancer-related death, with a 5-year survival rate of just 18%. Thanks to recent developments in targeted...
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Multi-omics in Study of Lung Microbiome
The lung microbiome influences the pathophysiology of pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cystic...
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Simple Models of Lung Development
Models are essential to further our understanding of lung development and regeneration and to facilitate identification and testing of potential...
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Targeting Epigenetics in Inflammatory Lung Diseases
This book discusses the role of epigenetics in pathogenesis of different pulmonary diseases, including chronic obstructive pulmonary disease, lung...
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ADRB2 inhibition combined with antioxidant treatment alleviates lung fibrosis by attenuating TGFβ/SMAD signaling in lung fibroblasts
Idiopathic pulmonary fibrosis is a progressive and fatal interstitial lung disease with a poor prognosis and limited therapeutic options, which is...
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Engineering Dynamic 3D Models of Lung
The lung parenchyma—consisting of gas-filled alveoli, vasculature, and connective tissue—is the site for gas exchange in the lung and plays a...
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MSCs alleviate LPS-induced acute lung injury by inhibiting the proinflammatory function of macrophages in mouse lung organoid–macrophage model
Acute lung injury (ALI) is an inflammatory disease associated with alveolar injury, subsequent macrophage activation, inflammatory cell infiltration,...
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Microbiome in Inflammatory Lung Diseases
This book reviews the role of the lung microbiome in the development and progression of lung diseases. It deals with the role of microbiota dysbiosis...
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Engineering and Modeling the Lung Mesenchyme
The structure of the mammalian lung controls the flow of air through the airways and into the distal alveolar region where gas exchange occurs....
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Multipotent Embryonic Lung Progenitors: Foundational Units of In Vitro and In Vivo Lung Organogenesis
Transient, tissue-specific, embryonic progenitors are important cell populations in vertebrate development. In the course of respiratory system...
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Gut microbiota modulates lung fibrosis severity following acute lung injury in mice
Independent studies demonstrate the significance of gut microbiota on the pathogenesis of chronic lung diseases; yet little is known regarding the...
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Decellularization of Pig Lung to Yield Three-Dimensional Scaffold for Lung Tissue Engineering
Lately, the need for three-dimensional (3D) cell culture has been recognized in order to closely mimic the organization of native tissues. Thus, 3D...
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Metagenomic sequencing reveals swine lung microbial communities and metagenome-assembled genomes associated with lung lesions—a pilot study
Low microbial biomass in the lungs, high host-DNA contamination and sampling difficulty limit the study on lung microbiome. Therefore, little is...
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Exploration of lung mycobiome in the patients with non-small-cell lung cancer
As the Human Microbiome Project (HMP) progresses, the relationship between microbes and human health has been receiving increasing attention. A...
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RNF128 regulates neutrophil infiltration and myeloperoxidase functions to prevent acute lung injury
Acute lung injury (ALI) is characterised by severe pulmonary inflammation, alveolar-capillary barrier disruption, and pulmonary oedema. Therefore,...
