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Epigenetics of Lung Cancer

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Targeting Epigenetics in Inflammatory Lung Diseases

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Abstract

Lung cancer is the biggest cause of cancer-related death, with a 5-year survival rate of just 18%. Thanks to recent developments in targeted pharmacological medications and immunotherapies, the survival rates of some patients have increased considerably. However, patients are usually only provided standard chemotherapy, which has a history of providing mediocre outcomes in the clinic. Accordingly, innovative methods of therapy are urgently required. Recent advances in epigenetic assessments and their use in research of cancer have shown the significance in the regulation of epigenetic lung cancer’s progression, development, initiation, and treatment. There are several epigenetic modifications that occur in lung cancer at different phases of progression, and some of them are essential for tumour growth. Improved considerate of the natural science behind lung cancer growth and the facilitation of the creation of novel treatment options are both dependent on the continued development of state-of-the-art technologies like single-cell epigenomics. As a consequence of this strategy, treatments that use either a single medication or a combination of medicines to target epigenetic modifiers have been created and are now being explored in clinical trials. In this chapter, we discuss the function of epigenetics in lung cancer at different stages of the disease and how this knowledge is being used in clinical practice.

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Authors and Affiliations

  1. Institute of Pharmaceutical Research, GLA University, Mathura, UP, India

    Vibhav Varshney, Ahsas Goyal & Neetu Agrawal

Authors
  1. Vibhav Varshney
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  2. Ahsas Goyal
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  3. Neetu Agrawal
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Corresponding author

Correspondence to Ahsas Goyal .

Editor information

Editors and Affiliations

  1. School of Pharmacy, Suresh Gyan University, Jaipur, Rajasthan, India

    Gaurav Gupta

  2. Department of Science, University of Technology Sydney, Ultimo, NSW, Australia

    Brian G. Oliver

  3. Discipline of Pharmacy, University of Technology Sydney, Schofields, NSW, Australia

    Kamal Dua

  4. Division of Pulmonary and Critical Care Medicine, Stanford Medicine, Stanford, CA, USA

    Md Khadem Ali

  5. School of Pharmacy, Gyan Vihar University, Jaipur, Rajasthan, India

    Piyush Dave

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Varshney, V., Goyal, A., Agrawal, N. (2023). Epigenetics of Lung Cancer. In: Gupta, G., Oliver, B.G., Dua, K., Ali, M.K., Dave, P. (eds) Targeting Epigenetics in Inflammatory Lung Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-99-4780-5_7

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