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Mechanics of Lung Development

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Roles of Skeletal Muscle in Organ Development

Part of the book series: Advances in Anatomy, Embryology and Cell Biology ((ADVSANAT,volume 236))

Abstract

We summarize how skeletal muscle and lung developmental biology fields have been bridged to benefit from mouse genetic engineering technologies and to explore the role of fetal breathing-like movements (FBMs) in lung development, by using skeletal muscle-specific mutant mice. It has been known for a long time that FBMs are essential for the lung to develop properly. However, the cellular and molecular mechanisms transducing the mechanical forces of muscular activity into specific genetic programs that propel lung morphogenesis (development of the shape, form and size of the lung, its airways, and gas exchange surface) as well as its differentiation (acquisition of specialized cell structural and functional features from their progenitor cells) are only starting to be revealed. This chapter is a brief synopsis of the cumulative findings from that ongoing quest. An update on and the rationale for our recent International Mouse Phenotyping Consortium (IMPC) search is also provided.

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada

    Mark Baguma-Nibasheka

  2. Department of Medical Neuroscience, Anatomy and Pathology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada

    Boris Kablar

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  1. Mark Baguma-Nibasheka
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  2. Boris Kablar
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Correspondence to Mark Baguma-Nibasheka .

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  1. Department of Medical Neuroscience, Anatomy and Pathology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada

    Boris Kablar

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The authors declare no conflict of interest. This chapter is a review of previously published accounts and as such, no animal or human studies were performed.

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Baguma-Nibasheka, M., Kablar, B. (2023). Mechanics of Lung Development. In: Kablar, B. (eds) Roles of Skeletal Muscle in Organ Development. Advances in Anatomy, Embryology and Cell Biology, vol 236. Springer, Cham. https://doi.org/10.1007/978-3-031-38215-4_6

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