Abstract
There has been a rise in the number of documented instances of lung illness in both children and adults around the globe. Both the morbidity and mortality rates associated with lung illness are from the unknown source. However, estimates from the GHO and other officialdoms imply that over 400 million people throughout the world are affected by asthma and COPD, most of them with very moderate symptoms. Non-infectious lung disease (LD) includes COPD, cystic fibrosis, asthma, lung cancer, and idiopathic pulmonary fibrosis (IPF), whereas infectious lung diseases include influenza, TB, and COPD. A combination of environmental circumstances, including an aging population and the absence of effective medications to the mild factor of LD, increased the chances of severe lung illnesses. With the widespread prevalence and devastating effects of lung diseases such as COPD, asthma, COVID-19, fibrosis, and flu-like symptoms, studies aimed at developing effective treatments and prevention measures are now being funded on a high-priority basis.
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References
Alharbi KS, Fuloria NK, Fuloria S, Rahman SB, Al-Malki WH, Javed Shaikh MA, et al. Nuclear factor-kappa B and its role in inflammatory lung disease. Chem Biol Interact. 2021;345:109568.
Chivima B. Lung cancer. Nurs Stand (Royal College of Nursing (Great Britain): 1987). 2015;29(22):61.
Abolfathi H, Sheikhpour M, Shahraeini SS, Khatami S, Nojoumi SA. Studies in lung cancer cytokine proteomics: a review. Expert Rev Proteomics. 2021;18(1):49–64.
Abu Rous F, Singhi EK, Sridhar A, Faisal MS, Desai A. Lung cancer treatment advances in 2022. Cancer Investig. 2023;41(1):12–24.
Amann A, Corradi M, Mazzone P, Mutti A. Lung cancer biomarkers in exhaled breath. Expert Rev Mol Diagn. 2011;11(2):207–17.
Avasarala SK, Rickman OB. Endobronchial therapies for diagnosis, staging, and treatment of lung cancer. Surg Clin North Am. 2022;102(3):393–412.
Bade BC, Dela Cruz CS. Lung cancer 2020: epidemiology, etiology, and prevention. Clin Chest Med. 2020;41(1):1–24.
Beattie EJ Jr. Lung cancer. CA Cancer J Clin. 1974;24(2):96–9.
Bitsko MJ, Everhart RS, Rubin BK. The adolescent with asthma. Paediatr Respir Rev. 2014;15(2):146–53.
Barnthouse M, Jones BL. The impact of environmental chronic and toxic stress on asthma. Clin Rev Allergy Immunol. 2019;57(3):427–38.
Anwar ET, Gupta N, Porwal O, Sharma A, Malviya R, Singh A, et al. Skin diseases and their treatment strategies in Sub-Saharan African Regions. Infect Disord Drug Targets. 2022;22(2):e270921196808.
Agache I, Palmer E, Sanver D, Kirtland M, Shamji MH. Molecular allergology approach to allergic asthma. Mol Asp Med. 2022;85:101027.
Boulet LP, Boulay M. Asthma-related comorbidities. Expert Rev Respir Med. 2011;5(3):377–93.
Dahiya R, Dahiya S, Fuloria NK, Kumar S, Mourya R, Chennupati SV, et al. Natural bioactive thiazole-based peptides from marine resources: structural and pharmacological aspects. Mar Drugs. 2020;18(6):329.
Busse WW, Melén E, Menzies-Gow AN. Holy Grail: the journey towards disease modification in asthma. Eur Respir Rev. 2022;31(163):210183.
Dahiya S, Dahiya R, Fuloria NK, Mourya R, Dahiya S, Fuloria S, et al. Natural bridged bicyclic peptide macrobiomolecules from celosia argentea and amanita phalloides. Mini Rev Med Chem. 2022;22(13):1772–88.
Chung KF. Clinical management of severe therapy-resistant asthma. Expert Rev Respir Med. 2017;11(5):395–402.
Jones TL, Neville DM, Chauhan AJ. Diagnosis and treatment of severe asthma: a phenotype-based approach. Clin Med. 2018;18(Suppl 2):s36–40.
Gans MD, Gavrilova T. Understanding the immunology of asthma: Pathophysiology, biomarkers, and treatments for asthma endotypes. Paediatr Respir Rev. 2020;36:118–27.
Fuloria NK, Raheja RK, Shah KH, Oza MJ, Kulkarni YA, Subramaniyan V, et al. Biological activities of meroterpenoids isolated from different sources. Front Pharmacol. 2022;13:830103.
Kaur R, Chupp G. Phenotypes and endotypes of adult asthma: moving toward precision medicine. J Allergy Clin Immunol. 2019;144(1):1–12.
Kwah JH, Peters AT. Asthma in adults: principles of treatment. Allergy Asthma Proc. 2019;40(6):396–402.
Larenas-Linnemann D. [Asthma treatment]. Revista alergia Mexico (Tecamachalco, Puebla, Mexico: 1993). 2009;56 Suppl 1:S64–78.
Lemanske RF Jr, Busse WW. Asthma. JAMA. 1997;278(22):1855–73.
Miller RL, Grayson MH, Strothman K. Advances in asthma: new understandings of asthma’s natural history, risk factors, underlying mechanisms, and clinical management. J Allergy Clin Immunol. 2021;148(6):1430–41.
Mims JW. Asthma: definitions and pathophysiology. Int Forum Allergy Rhinol. 2015;5(Suppl 1):S2–6.
Ntontsi P, Photiades A, Zervas E, Xanthou G, Samitas K. Genetics and epigenetics in asthma. Int J Mol Sci. 2021;22(5):2412.
Fuloria S, Mehta J, Talukdar MP, Sekar M, Gan SH, Subramaniyan V, et al. Synbiotic effects of fermented rice on human health and wellness: a natural beverage that boosts immunity. Front Microbiol. 2022;13:950913.
Fuloria S, Sekar M, Khattulanuar FS, Gan SH, Rani N, Ravi S, et al. Chemistry, biosynthesis and pharmacology of viniferin: potential resveratrol-derived molecules for new drug discovery, development and therapy. Molecules. 2022;27(16):5072.
Papadopoulos NG, Miligkos M, Xepapadaki P. A current perspective of allergic asthma: from mechanisms to management. Handb Exp Pharmacol. 2022;268:69–93.
Sockrider M, Fussner L. What is asthma? Am J Respir Crit Care Med. 2020;202(9):P25–6.
Wu TD, Brigham EP, McCormack MC. Asthma in the primary care setting. Med Clin North Am. 2019;103(3):435–52.
COPD. Nurs Stand (Royal College of Nursing (Great Britain): 1987). 2015;29(42):16.
López-Campos JL, Tan W, Soriano JB. Global burden of COPD. Respirology. 2016;21(1):14–23.
Fuloria S, Subramaniyan V, Dahiya R, Dahiya S, Sudhakar K, Kumari U, et al. Mesenchymal stem cell-derived extracellular vesicles: regenerative potential and challenges. Biology. 2021;10(3):172.
Fuloria S, Yusri MAA, Sekar M, Gan SH, Rani N, Lum PT, et al. Genistein: a potential natural lead molecule for new drug design and development for treating memory impairment. Molecules. 2022;27(1):265.
Agustí A, Vogelmeier C, Faner R. COPD 2020: changes and challenges. Am J Physiol Lung Cell Mol Physiol. 2020;319(5):L879–l83.
Bagdonas E, Raudoniute J, Bruzauskaite I, Aldonyte R. Novel aspects of pathogenesis and regeneration mechanisms in COPD. Int J Chron Obstruct Pulmon Dis. 2015;10:995–1013.
Raherison C, Girodet PO. Epidemiology of COPD. Eur Respir Rev. 2009;18(114):213–21.
Barnes PJ. COPD 2020: new directions needed. Am J Physiol Lung Cell Mol Physiol. 2020;319(5):L884–l6.
Erhabor GE, Adeniyi B, Arawomo AO, Akinwalere O, Adetona G, Fagbohun FT, et al. Acute exacerbation of COPD: clinical perspectives and literature review. West Afr J Med. 2021;38(11):1129–42.
Fischer BM, Voynow JA, Ghio AJ. COPD: balancing oxidants and antioxidants. Int J Chron Obstruct Pulmon Dis. 2015;10:261–76.
Guerreiro I, Soccal PM. [COPD and phenotypes]. Rev Med Suisse 2019;15(671):2082–6.
Tantucci C, Modina D. Lung function decline in COPD. Int J Chron Obstruct Pulmon Dis. 2012;7:95–9.
Gupta G, Almalki WH, Kazmi I, Fuloria NK, Fuloria S, Subramaniyan V, et al. Current update on the protective effect of naringin in inflammatory lung diseases. EXCLI J. 2022;21:573–9.
Hamid UZ, Sim MS, Guad RM, Subramaniyan V, Sekar M, Fuloria NK, et al. Molecular regulatory roles of long non-coding RNA HOTTIP: an overview in gastrointestinal cancers. Curr Mol Med. 2022;22(6):478–90.
Uwagboe I, Adcock IM, Lo Bello F, Caramori G, Mumby S. New drugs under development for COPD. Minerva Med. 2022;113(3):471–96.
Agusti A, Soriano JB. COPD as a systemic disease. COPD. 2008;5(2):133–8.
Aryal S, Diaz-Guzman E, Mannino DM. COPD and gender differences: an update. Transl Res. 2013;162(4):208–18.
Barnes PJ. Endo-phenotyping of COPD patients. Expert Rev Respir Med. 2021;15(1):27–37.
Huqh MZU, Abdullah JY, Wong LS, Jamayet NB, Alam MK, Rashid QF, et al. Clinical applications of artificial intelligence and machine learning in children with cleft lip and palate-a systematic review. Int J Environ Res Public Health. 2022;19(17):10860.
Jha S, Malviya R, Fuloria S, Sundram S, Subramaniyan V, Sekar M, et al. Characterization of microwave-controlled polyacrylamide graft copolymer of tamarind seed polysaccharide. Polymers. 2022;14(5):1037.
Kaur I, Behl T, Sehgal A, Singh S, Sharma N, Subramanian V, et al. A motley of possible therapies of the COVID-19: reminiscing the origin of the pandemic. Environ Sci Pollut Res Int. 2022;29(45):67685–703.
Kumar S, Behl T, Sehgal A, Chigurupati S, Singh S, Mani V, et al. Exploring the focal role of LRRK2 kinase in Parkinson’s disease. Environ Sci Pollut Res Int. 2022;29(22):32368–82.
Chakinala RC, Khatri A, Gupta K, Koike K, Epelbaum O. Sphingolipids in COPD. Eur Respir Rev. 2019;28(154):190047.
Duffy SP, Criner GJ. Chronic Obstructive Pulmonary Disease: Evaluation and Management. Med Clin North Am. 2019;103(3):453–61.
Gupta N, Agrawal S, Chakrabarti S, Ish P. COPD 2020 guidelines - what is new and why? Adv Respir Med. 2020;88(1):38–40.
Hanania NA, Sharma G, Sharafkhaneh A. COPD in the elderly patient. Semin Respir Crit Care Med. 2010;31(5):596–606.
Hattab Y, Alhassan S, Balaan M, Lega M, Singh AC. Chronic obstructive pulmonary disease. Crit Care Nurs Q. 2016;39(2):124–30.
Hering T. [COPD: Capture an exacerbation with just five questions]. MMW Fortschr Med 2022;164(10):61–3.
Labaki WW, Rosenberg SR. Chronic obstructive pulmonary disease. Ann Intern Med. 2020;173(3):Itc17–32.
Mortensen J, Berg RMG. Lung scintigraphy in COPD. Semin Nucl Med. 2019;49(1):16–21.
Lum PT, Sekar M, Gan SH, Jeyabalan S, Bonam SR, Rani N, et al. Therapeutic potential of mangiferin against kidney disorders and its mechanism of action: a review. Saudi J Biol Sci. 2022;29(3):1530–42.
Malviya R, Fuloria S, Verma S, Subramaniyan V, Sathasivam KV, Kumarasamy V, et al. Commercial utilities and future perspective of nanomedicines. PeerJ. 2021;9:e12392.
Petty TL. COPD in perspective. Chest. 2002;121(5 Suppl):116s–20s.
Rabe KF, Watz H. Chronic obstructive pulmonary disease. Lancet. 2017;389(10082):1931–40.
Tan WSD, Shen HM, Wong WSF. Dysregulated autophagy in COPD: a pathogenic process to be deciphered. Pharmacol Res. 2019;144:1–7.
Sethi T. Lung cancer.Introduction. Thorax. 2002;57(11):992–3.
Mustafa NH, Sekar M, Fuloria S, Begum MY, Gan SH, Rani N, et al. Chemistry, biosynthesis and pharmacology of sarsasapogenin: a potential natural steroid molecule for new drug design, development and therapy. Molecules. 2022;27(6):2032.
Nasir NN, Sekar M, Fuloria S, Gan SH, Rani N, Ravi S, et al. Kirenol: a potential natural lead molecule for a new drug design, development, and therapy for inflammation. Molecules. 2022;27(3):734.
Seale DD, Beaver BM. Pathophysiology of lung cancer. Nurs Clin North Am. 1992;27(3):603–13.
Rodescu D. Lung cancer. Med Clin North Am. 1977;61(6):1205–18.
Ruppert AM, Amrioui F, Fallet V. [Risk factors and prevention of lung cancer]. Rev Prat 2020;70(8):852–6.
Selvaraj LK, Jeyabalan S, Wong LS, Sekar M, Logeshwari B, Umamaheswari S, et al. Baicalein prevents stress-induced anxiety behaviors in zebrafish model. Front Pharmacol. 2022;13:990799.
Selvaraj S, Naing NN, Wan-Arfah N, Djearamane S, Wong LS, Subramaniyan V, et al. Epidemiological factors of periodontal disease among south indian adults. J Multidiscip Healthc. 2022;15:1547–57.
McComb BL, Ko JP. Lung cancer imaging. J Thorac Imaging. 2011;26(2):83–4.
Novello S, Vavalà T. Lung cancer and women. Future Oncol. 2008;4(5):705–16.
Singh S, Hema, Sharma N, Sachdeva M, Behl T, Zahoor I, et al. Focusing the pivotal role of nanotechnology in Huntington’s disease: an insight into the recent advancements. Environ Sci Pollut Res Int. 2022;29(49):73809–27.
Subramaniyan V, Chakravarthi S, Jegasothy R, Seng WY, Fuloria NK, Fuloria S, et al. Alcohol-associated liver disease: a review on its pathophysiology, diagnosis and drug therapy. Toxicol Rep. 2021;8:376–85.
Chellappan DK, Chellian J, Leong JQ, Liaw YY, Gupta G, Dua K, et al. Biological and therapeutic potential of the edible brown marine seaweed Padina australis and their pharmacological mechanisms. J Trop Biol Conserv. 2020;17:251–71–71.
Krasna MJ. Lung cancer. Surg Oncol Clin N Am. 2011;20(4):xv–xvi.
Gudbjartsson T, Smáradottir A, Skúladóttir H, Grímsson HN, Hardardóttir H, Björnsson J, et al. [Lung cancer - review]. Laeknabladid 2008;94(4):297–311.
Giaccone G, Smit E. Lung cancer. Cancer Chemother Biol Response Modif. 2005;22:413–42.
Gilliland FD, Samet JM. Lung cancer. Cancer Surv. 1994;19–20:175–95.
Ernster VL. Female lung cancer. Annu Rev Public Health. 1996;17:97–114.
Vavalà T, Catino A, Pizzutilo P, Longo V, Galetta D. Gender Differences and Immunotherapy Outcome in Advanced Lung Cancer. Int J Mol Sci. 2021;22(21):11942.
Stanton BF. Cystic fibrosis. Pediatr Clin N Am. 2016;63(4):xv.
Savant AP, McColley SA. Cystic fibrosis year in review 2018, part 2. Pediatr Pulmonol. 2019;54(8):1129–40.
Savant AP, McColley SA. Cystic fibrosis year in review 2018, part 1. Pediatr Pulmonol. 2019;54(8):1117–28.
Savant AP, McColley SA. Cystic fibrosis year in review 2016. Pediatr Pulmonol. 2017;52(8):1092–102.
Rafeeq MM, Murad HAS. Cystic fibrosis: current therapeutic targets and future approaches. J Transl Med. 2017;15(1):84.
Paranjape SM, Mogayzel PJ Jr. Cystic fibrosis. Pediatr Rev. 2014;35(5):194–205.
Radlović N. Cystic fibrosis. Srp Arh Celok Lek. 2012;140(3–4):244–9.
Leitch AE, Rodgers HC. Cystic fibrosis. J R Coll Physicians Edinb. 2013;43(2):144–50.
Ooi CY, Durie PR. Cystic fibrosis from the gastroenterologist’s perspective. Nat Rev Gastroenterol Hepatol. 2016;13(3):175–85.
Klimova B, Kuca K, Novotny M, Maresova P. Cystic fibrosis revisited - a review study. Med Chem. 2017;13(2):102–9.
De Boeck K. Cystic fibrosis in the year 2020: a disease with a new face. Acta Paediatr. 2020;109(5):893–9.
Endres TM, Konstan MW. What is cystic fibrosis? JAMA. 2022;327(2):191.
Hewlett JC, Kropski JA, Blackwell TS. Idiopathic pulmonary fibrosis: epithelial-mesenchymal interactions and emerging therapeutic targets. Matrix Biol. 2018;71–72:112–27.
King TE Jr, Pardo A, Selman M. Idiopathic pulmonary fibrosis. Lancet. 2011;378(9807):1949–61.
Kishaba T. Acute exacerbation of idiopathic pulmonary fibrosis. Medicina (Kaunas). 2019;55(3):70.
Lederer DJ, Martinez FJ. Idiopathic pulmonary fibrosis. N Engl J Med. 2018;378(19):1811–23.
León-Román F, Valenzuela C, Molina-Molina M. Idiopathic pulmonary fibrosis. Med Clin. 2022;159(4):189–94.
Martinez FJ, Collard HR, Pardo A, Raghu G, Richeldi L, Selman M, et al. Idiopathic pulmonary fibrosis. Nat Rev Dis Primers. 2017;3:17074.
Moss BJ, Ryter SW, Rosas IO. Pathogenic mechanisms underlying idiopathic pulmonary fibrosis. Annu Rev Pathol. 2022;17:515–46.
Cardona PJ. Pathogenesis of tuberculosis and other mycobacteriosis. Enferm Infecc Microbiol Clin (Engl Ed). 2018;36(1):38–46.
Casas I, Dominguez J, Rodríguez S, Matllo J, Altet N. [Guidelines for the prevention and control of tuberculosis in health care workers]. Med Clin. 2015;145(12):534.e1–13.
Jové N, Masdeu E, Brugueras S, Millet JP, Ospina JE, Orcau À, et al. Threats and interventions during the treatment of tuberculosis in an inner-city district. Arch Bronconeumol. 2021;57(5):330–7.
Ting BYS, Fuloria NK, Subrimanyan V, Bajaj S, Chinni SV, Reddy LV, et al. Biosynthesis and response of zinc oxide nanoparticles against periimplantitis triggering pathogens. Materials (Basel). 2022;15(9):3170.
Tune BXJ, Sim MS, Poh CL, Guad RM, Woon CK, Hazarika I, et al. Matrix metalloproteinases in chemoresistance: regulatory roles, molecular interactions, and potential inhibitors. J Oncol. 2022;2022:3249766.
Ketata W, Rekik WK, Ayadi H, Kammoun S. [Extrapulmonary tuberculosis]. Rev Pneumol Clin 2015;71(2–3):83–92.
Margarit A, Simó S, Rozas L, Deyà-Martínez À, Barrabeig I, Gené A, et al. [Adolescent tuberculosis; a challenge and opportunity to prevent community transmission]. An Pediatr (Barc). 2017;86(3):110–4.
Orcau À, Caylà JA, Martínez JA. Present epidemiology of tuberculosis. Prevention and control programs. Enferm Infecc Microbiol Clin. 2011;29(Suppl 1):2–7.
Yap KM, Sekar M, Wu YS, Gan SH, Rani N, Seow LJ, et al. Hesperidin and its aglycone hesperetin in breast cancer therapy: a review of recent developments and future prospects. Saudi J Biol Sci. 2021;28(12):6730–47.
Zahoor I, Singh S, Behl T, Sharma N, Naved T, Subramaniyan V, et al. Emergence of microneedles as a potential therapeutics in diabetes mellitus. Environ Sci Pollut Res Int. 2022;29(3):3302–22.
Schito M, Migliori GB, Fletcher HA, McNerney R, Centis R, D’Ambrosio L, et al. Perspectives on advances in tuberculosis diagnostics, drugs, and vaccines. Clin Infect Dis. 2015;61Suppl 3(Suppl 3):S102–18.
Solsona Peiró J, de Souza Galvão ML, Altet Gómez MN. Inactive fibrotic lesions versus pulmonary tuberculosis with negative bacteriology. Arch Bronconeumol. 2014;50(11):484–9.
Hoa LNM, Sullivan SG, Mai LQ, Khvorov A, Phuong HVM, Hang NLK, et al. Influenza A(H1N1)pdm09 But Not A(H3N2) virus infection induces durable seroprotection: results from the ha nam cohort. J Infect Dis. 2022;226(1):59–69.
Zuraini NZA, Sekar M, Wu YS, Gan SH, Bonam SR, Mat Rani NNI, et al. Promising nutritional fruits against cardiovascular diseases: an overview of experimental evidence and understanding their mechanisms of action. Vasc Health Risk Manag. 2021;17:739–69.
Itoh Y. Translational research on influenza virus infection using a nonhuman primate model. Pathol Int. 2016;66(3):132–41.
Mifsud EJ, Kuba M, Barr IG. Innate immune responses to influenza virus infections in the upper respiratory tract. Viruses. 2021;13(10):2090.
Sura T, Gering V, Cammann C, Hammerschmidt S, Maaß S, Seifert U, et al. Streptococcus pneumoniae and influenza A virus co-infection induces altered polyubiquitination in A549 cells. Front Cell Infect Microbiol. 2022;12:817532.
Pantin-Jackwood MJ, Swayne DE. Pathogenesis and pathobiology of avian influenza virus infection in birds. Rev Sci Tech. 2009;28(1):113–36.
Alsharif W, Qurashi A. Effectiveness of COVID-19 diagnosis and management tools: a review. Radiography (Lond). 2021;27(2):682–7.
Amit S, Beni SA, Biber A, Grinberg A, Leshem E, Regev-Yochay G. Postvaccination COVID-19 among Healthcare Workers, Israel. Emerg Infect Dis. 2021;27(4):1220–2.
Fernandes Q, Inchakalody VP, Merhi M, Mestiri S, Taib N, Moustafa Abo El-Ella D, et al. Emerging COVID-19 variants and their impact on SARS-CoV-2 diagnosis, therapeutics and vaccines. Ann Med. 2022;54(1):524–40.
Habas K, Nganwuchu C, Shahzad F, Gopalan R, Haque M, Rahman S, et al. Resolution of coronavirus disease 2019 (COVID-19). Expert Rev Anti-Infect Ther. 2020;18(12):1201–11.
Majumder J, Minko T. Recent developments on therapeutic and diagnostic approaches for COVID-19. AAPS J. 2021;23(1):14.
Safiabadi Tali SH, LeBlanc JJ, Sadiq Z, Oyewunmi OD, Camargo C, Nikpour B, et al. Tools and techniques for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)/COVID-19 detection. Clin Microbiol Rev. 2021;34(3):e00228–0.
Sidiq Z, Hanif M, Dwivedi KK, Chopra KK. Benefits and limitations of serological assays in COVID-19 infection. Indian J Tuberc. 2020;67(4s):S163–s6.
Umakanthan S, Sahu P, Ranade AV, Bukelo MM, Rao JS, Abrahao-Machado LF, et al. Origin, transmission, diagnosis and management of coronavirus disease 2019 (COVID-19). Postgrad Med J. 2020;96(1142):753–8.
Yüce M, Filiztekin E, Özkaya KG. COVID-19 diagnosis - a review of current methods. Biosens Bioelectron. 2021;172:112752.
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Subramaniyan, V. et al. (2023). Introduction to Lung Disease. In: Gupta, G., Oliver, B.G., Dua, K., Ali, M.K., Dave, P. (eds) Targeting Epigenetics in Inflammatory Lung Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-99-4780-5_1
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