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Aspartoacylase promotes the process of tumour development and is associated with immune infiltrates in gastric cancer
BackgroundAspartoacylase (ASPA) is a gene that plays an important role in the metabolic reprogramming of cancer. However, the clinical relevance of...
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Gene Therapy in Molecular Biology and Drug Delivery
The objective of gene therapy is to manipulate/modify the gene expression or modify living cell characteristics for therapeutic utilization. It aims...
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AAV-based in vivo gene therapy for neurological disorders
Recent advancements in gene supplementation therapy are expanding the options for the treatment of neurological disorders. Among the available...
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Identification of the Shared Gene Signatures and Biological Mechanisms in Hyperplastic Enlarged Lobular Units and Breast Cancer
Breast cancer is a common cancer worldwide. Hyperplastic enlarged lobular units (HELUs) are common changes in the breasts of adult women. HELUs may...
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Disrupted myelin lipid metabolism differentiates frontotemporal dementia caused by GRN and C9orf72 gene mutations
Heterozygous mutations in the GRN gene and hexanucleotide repeat expansions in C9orf72 are the two most common genetic causes of Frontotemporal...
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Sex-based disparities in DNA methylation and gene expression in late-gestation mouse placentas
BackgroundThe placenta is vital for fetal development and its contributions to various developmental issues, such as pregnancy complications, fetal...
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Transcriptomic profiling of high- and low-spiking regions reveals novel epileptogenic mechanisms in focal cortical dysplasia type II patients
Focal cortical dysplasia (FCD) is a malformation of the cerebral cortex with poorly-defined epileptogenic zones (EZs), and poor surgical outcome in...
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Distinguishable DNA methylation defines a cardiac-specific epigenetic clock
BackgroundThe present study investigates whether epigenetic differences emerge in the heart of patients undergoing cardiac surgery for an aortic...
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Gene Therapy Approach with an Emphasis on Growth Factors: Theoretical and Clinical Outcomes in Neurodegenerative Diseases
The etiology of many neurological diseases affecting the central nervous system (CNS) is unknown and still needs more effective and specific...
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Uncovering potential genes in colorectal cancer based on integrated and DNA methylation analysis in the gene expression omnibus database
BackgroundColorectal cancer (CRC) is major cancer-related death. The aim of this study was to identify differentially expressed and differentially...
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Nuclear Inhibitor of Protein Phosphatase 1 (NIPP1) Regulates CNS Tau Phosphorylation and Myelination During Development
Nuclear inhibitor of protein phosphatase 1 (NIPP1) is a known regulator of gene expression and plays roles in many physiological or pathological...
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Transcriptome analysis identifies an ASD-Like phenotype in oligodendrocytes and microglia from C58/J amygdala that is dependent on sex and sociability
BackgroundAutism Spectrum Disorder (ASD) is a group of neurodevelopmental disorders with higher incidence in males and is characterized by atypical...
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An asparagine metabolism-based classification reveals the metabolic and immune heterogeneity of hepatocellular carcinoma
Introduction and objectiveshepatocellular carcinoma (HCC) is the major form of liver cancer with a poor prognosis. Amino acid metabolism has been...
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Antimicrobial peptide moricin induces ROS mediated caspase-dependent apoptosis in human triple-negative breast cancer via suppression of notch pathway
BackgroundBreast cancer is the world’s most prevalent cancer among women. Microorganisms have been the richest source of antibiotics as well as...
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Nf1 mutation disrupts activity-dependent oligodendroglial plasticity and motor learning in mice
Neurogenetic disorders, such as neurofibromatosis type 1 (NF1), can cause cognitive and motor impairments, traditionally attributed to intrinsic...
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Role of lncRNAs in Remodeling of the Coronary Artery Plaques in Patients with Atherosclerosis
IntroductionCardiovascular diseases (CVDs) are the leading cause of death worldwide according to World Health Organization (WHO) data....
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Genetic susceptibility to optic neuropathy in patients with alcohol use disorder
BackgroundThe pathophysiology of toxico-nutritional optic neuropathies remains debated, with no clear understanding of the respective roles played by...
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Immunological Markers for Central Nervous System Glia
Glial cells in the central nervous system (CNS) are composed of oligodendrocytes, astrocytes and microglia. They contribute more than half of the...
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Miscarriage risk assessment: a bioinformatic approach to identifying candidate lethal genes and variants
PurposeMiscarriage, often resulting from a variety of genetic factors, is a common pregnancy outcome. Preconception genetic carrier screening (PGCS)...
