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Identification of the Shared Gene Signatures and Biological Mechanisms in Hyperplastic Enlarged Lobular Units and Breast Cancer

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Abstract

Breast cancer is a common cancer worldwide. Hyperplastic enlarged lobular units (HELUs) are common changes in the breasts of adult women. HELUs may be closely related to the occurrence and development of breast cancer. In this study, genes that are commonly contained in the expression profiles of the genomes of the two diseases and have significant differences in expression before and after the respective diseases were identified. Various enrichment analyses were performed according to the expression levels of these differentially expressed genes. Furthermore, LASSO regression analysis was performed on the differentially expressed genes to identify genes significantly related to survival. The optimal risk model for the survival of patients with breast cancer was established, and the accuracy of the model was verified on multiple data sets. A gene combination containing 17 genes was ultimately determined to be an independent prognostic factor. Kaplan‒Meier survival analysis demonstrated the good performance of this risk model. The study found that Shared Gene Signatures and Biological Mechanisms in Hyperplastic Enlarged Lobular Units and Breast Cancer, screened 17 important Shared Gene Signatures of Hyperplastic Enlarged Lobular Units which are closely related to the survival of breast cancer patients through machine learning, and established a prognosis model with high-accuracy, which is worthy of further exploration.

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Data Availability

The datasets analysed during the current study are available in The Cancer Genome Atlas (TCGA https://portal.gdc.cancer.gov/) and Gene Expression Omnibus (GEO https://portal.gdc.cancer.gov/) repository.

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Acknowledgements

Not applicable.

Funding

This research was supported by the Shanghai Health Committee (202240173), partly funded by Shanghai University of Health & Medicine Sciences (SSF-2022–24-29, SSF-2022–24-30), the Natural Science Foundation of Jiangsu Province (BK20210949) and Chongming Science and Technology Committee (CKY2021-38).

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Author notes

  1. Kuiyuan Tong, Zihao Yang and Shiyu Jin contributed equally to this work.

Authors and Affiliations

  1. Faculty of Life Science and Food Engineering, Huaiyin Institute of Technology, Huaian, 223003, Jiangsu, China

    Kuiyuan Tong, Zihao Yang, Shiyu Jin & Shiyan Wang

  2. Translational Institute for Cancer Pain, Chongming Hospital Affiliated to Shanghai University of Health & Medicine Sciences (Xinhua Hospital Chongming Branch), Shanghai, 202150, China

    Wanli Yang, Ruihua Yu, Chao Yang & Feng Jiang

  3. Jiangsu Provincial Engineering Laboratory for Biomass Conversion and Process Integration, Huaiyin Institute of Technology, Huaian, 223003, Jiangsu, China

    Shiyan Wang

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  1. Kuiyuan Tong
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  4. Wanli Yang
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Contributions

KYT performed the computational experiments, analyzed results and write the manuscript. ZHY, RHY and WLY helped to write the manuscript. CY, FJ, SYJ and SYW conceived the project, advised on the analysis, and supervised the research and wrote the manuscript. All authors read and approved the final manuscript.

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Correspondence to Shiyan Wang, Chao Yang or Feng Jiang.

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Tong, K., Yang, Z., Jin, S. et al. Identification of the Shared Gene Signatures and Biological Mechanisms in Hyperplastic Enlarged Lobular Units and Breast Cancer. Biochem Genet (2023). https://doi.org/10.1007/s10528-023-10588-2

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