Astrocyte Gliotransmission in the Regulation of Systemic Metabolism
Abstract
:1. Introduction
Astrocyte Gliotransmission: The Hallmark of Astrocyte Communication
- Vesicle-mediated exocytosis
- The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-mediated vesicular exocytosis is likely the major mechanism for the Ca2+-sensitive release of gliotransmitters from astrocytes. Using ex vivo brain slices from mice and human, it was observed that Ca2+-dependent astrocyte-released glutamate induces the activation of N-methyl-D-aspartate receptors (NMDARs) in neurons triggering slow inward currents [29,30,31,32], an effect greatly attenuated by disrupting the SNARE complex [33,34,35]. These currents have also been shown to be associated with changes in neuronal excitability and neurotransmission. Accordingly, vesicular glutamate transporters and SNARE proteins are localized in astrocyte processes adjacent to neurons [35]. The blockade of vesicular exocytosis also impairs the release of ATP from astrocytes, which may influence synaptic transmission and behavioral responses [36,37,38,39]. Likewise, the exocytosis of lysosomes is also thought to participate in ATP release from astrocytes [40,41].
- Diffusion through channels
- In addition to exocytotic mechanisms, the release of astrocyte gliotransmitters may occur through ion channels. For instance, glutamate can be released via Ca2+-activated bestrophin 1 (BEST1) channels localized at astrocyte microdomains [42] to modulate synaptic plasticity [43,44]. BEST1 channels are also permeable to GABA, which may tonically inhibit neighboring neurons [45,46,47] and drive pathological mechanisms following its impaired release [48,49]. Moreover, astrocytes are able to release gliotransmitters via hemichannels [50,51,52,53,54] and Ca2+-independent pathways, such as two-pore domain K+ channels [42,55].
2. Physiological Processes by Which Astrocytes Regulate Systemic Metabolism
2.1. Cerebral Vascular Integrity and Remodeling
2.2. Brain Glucose Sensing
2.2.1. Hypothalamus
2.2.2. Hindbrain
2.3. Feeding Circuits
2.3.1. Identified Gliotransmitters by Which Astrocytes Regulate Feeding Behavior
ATP/Adenosine
Endozepines
Prostaglandin E2
2.4. Circadian Rhythms
3. Concluding Remarks
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Murat, C.D.B.; García-Cáceres, C. Astrocyte Gliotransmission in the Regulation of Systemic Metabolism. Metabolites 2021, 11, 732. https://doi.org/10.3390/metabo11110732
Murat CDB, García-Cáceres C. Astrocyte Gliotransmission in the Regulation of Systemic Metabolism. Metabolites. 2021; 11(11):732. https://doi.org/10.3390/metabo11110732
Chicago/Turabian StyleMurat, Cahuê De Bernardis, and Cristina García-Cáceres. 2021. "Astrocyte Gliotransmission in the Regulation of Systemic Metabolism" Metabolites 11, no. 11: 732. https://doi.org/10.3390/metabo11110732