VEGF in Signaling and Disease: Beyond Discovery and Development
- PMID: 30849371
- PMCID: PMC6410740
- DOI: 10.1016/j.cell.2019.01.021
VEGF in Signaling and Disease: Beyond Discovery and Development
Abstract
The discovery of vascular endothelial-derived growth factor (VEGF) has revolutionized our understanding of vasculogenesis and angiogenesis during development and physiological homeostasis. Over a short span of two decades, our understanding of the molecular mechanisms by which VEGF coordinates neurovascular homeostasis has become more sophisticated. The central role of VEGF in the pathogenesis of diverse cancers and blinding eye diseases has also become evident. Elucidation of the molecular regulation of VEGF and the transformative development of multiple therapeutic pathways targeting VEGF directly or indirectly is a powerful case study of how fundamental research can guide innovation and translation. It is also an elegant example of how agnostic discovery and can transform our understanding of human disease. This review will highlight critical nodal points in VEGF biology, including recent developments in immunotherapy for cancer and multitarget approaches in neovascular eye disease.
Copyright © 2019 Elsevier Inc. All rights reserved.
Figures
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References
-
- Adamis AP, and Shima DT (2005). The role of vascular endothelial growth factor in ocular health and disease. Retina 25, 111–118. - PubMed
-
- Algire GH, Chalkley HW, Legallais FY, and Park HD (1945). Vascular reactions of normal and malignant tissues in vivo. I. Vascular reactions of mice to wounds and to normal and neoplastic transplants. J Natl Cancer Inst 6, 73–85.
-
- Alitalo K, Tammela T, and Petrova TV (2005). Lymphangiogenesis in development and human disease. Nature 438, 946–953. - PubMed
-
- Apte RS (2016). What Is Chronic or Persistent Diabetic Macular Edema and How Should It Be Treated? JAMA Ophthalmol 134, 285–286. - PubMed
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