Review
doi: 10.1038/nrn3878.
Epub 2015 Mar 11.
Disentangling calcium-driven astrocyte physiology
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- PMID: 25757560
- DOI: 10.1038/nrn3878
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Review
Disentangling calcium-driven astrocyte physiology
Nat Rev Neurosci.
2015 Apr.
Abstract
Astrocytes seem to rely on relatively sluggish and spatially blurred Ca(2+) waves to communicate with fast and point-precise neural circuits. This apparent discrepancy could, however, reflect our current inability to understand the microscopic mechanisms involved. Difficulties in detecting and interpreting astrocyte Ca(2+) signals may have led to some prominent controversies in the field. Here, we argue that a deeper understanding of astrocyte physiology requires a qualitative leap in our experimental and analytical strategies.
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