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Gregory L Damhorst, A Wendy Fujita, Eric Fitts, Brittany Szabo, Heather B Bowers, Courtney Sabino, Alaa Ahmed, Ethan Wang, Anne Piantadosi, Kaleb McLendon, Julie Sullivan, Morgan Greenleaf, Divine McCaslin, Melody Palmore, Albert M Anderson, Bruce Aldred, Clifford Gunthel, Greg S Martin, Jonathan A Colasanti, Wilbur A Lam, Leda Bassit, Anuradha Rao, Anandi N Sheth, Boghuma K Titanji, Multisite Mpox Infection and Viral Dynamics Among Persons With HIV in Metro Atlanta, The Journal of Infectious Diseases, Volume 229, Issue Supplement_2, 15 April 2024, Pages S213–S218, https://doi.org/10.1093/infdis/jiad530
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Abstract
The 2022 mpox outbreak primarily involved sexual transmission among men who have sex with men and disproportionately affected persons with human immunodeficiency virus (HIV). We examined viral dynamics and clinical features in a cohort evaluated for mpox infection at a comprehensive HIV clinic in Atlanta, Georgia. Viral DNA was found in 8 oropharyngeal and 5 anorectal specimens among 10 mpox cases confirmed by lesion swab polymerase chain reaction. Within-participant anatomic site of lowest cycle threshold (Ct) value varied, and lower Ct values were found in oropharyngeal and anorectal swabs when corresponding symptoms were present. This provides insight into mpox infection across multiple anatomic sites among people with HIV.