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Nouria Belkacem, Ala-Eddine Deghmane, Muhamed-Kheir Taha, Biofilm Formation by Nontypeable Haemophilus Influenzae and Resistance to Complement-Mediated Clearance, The Journal of Infectious Diseases, Volume 229, Issue 6, 15 June 2024, Pages 1674–1678, https://doi.org/10.1093/infdis/jiad584
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Abstract
Biofilm formation has been suggested to be associated with phenotype changes compared with the planktonic form. We screened 1092 Haemophilus influenzae isolates for their genetic relationships and then selected 29 isolates from different genotypes and phenotypes and tested their ability to form biofilm. Our data showed a higher capacity of nontypable isolates, particularly isolates from respiratory and genital infections to form biofilm, compared with typable isolates. This ability to form biofilm was also correlated with reduced deposition of the complement component C3b on biofilm-involved bacteria. These data suggest that the biofilm formation contributes to the virulence of nontypable H. influenzae.