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Huntington’s disease and schizophrenia-derived glia share common mechanisms... Get access
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Shared patterns of glial transcriptional dysregulation link Huntington’s disease and schizophrenia
Published: 19 July 2024
Figure 1
Huntington’s disease and schizophrenia-derived glia share common mechanisms of disrupted glial differentiation. ( A–E ) Assessment of differential and shared gene expression by Huntington’s disease (HD) and schizophrenia (SCZ) glial progenitor cells (GPCs). ( A ) Venn diagram depicting the number o
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Synapse-regulatory pathways were dysregulated in both Huntington’s disease ... Get access
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Shared patterns of glial transcriptional dysregulation link Huntington’s disease and schizophrenia
Published: 19 July 2024
Figure 4
Synapse-regulatory pathways were dysregulated in both Huntington’s disease and schizophrenia human glial progenitor cells. ( A ) The multilayered gene correlation network was composed from 1218 genes shared among prioritized modules in Fig. 3A . Node colour indicates which cluster each gene was as
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Suppression of OLIG2 and TCF7L2-dependent modulators of glutamatergic synap... Get access
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Shared patterns of glial transcriptional dysregulation link Huntington’s disease and schizophrenia
Published: 19 July 2024
Figure 5
Suppression of OLIG2 and TCF7L2-dependent modulators of glutamatergic synapses. ( A ) Transcription factors enriched for top-ranked genes. ( B ) OLIG2 expression is high in glial progenitor cells (GPCs) and low in astrocytes. ( C ) OLIG2 occupancy at the transcription start sites of prioritized gen
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Gene set intersection highlights related clusters with distinct functions. ... Get access
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Shared patterns of glial transcriptional dysregulation link Huntington’s disease and schizophrenia
Published: 19 July 2024
Figure 3
Gene set intersection highlights related clusters with distinct functions. ( A ) The module gene set network was compiled from the significant gene set intersection between prioritized disease-associated modules. The nodes represent the modules and the edges represent the significant pairwise gene
Journal Article
Shared patterns of glial transcriptional dysregulation link Huntington’s disease and schizophrenia Get access
Brain, awae166, https://doi.org/10.1093/brain/awae166
Published: 19 July 2024
Journal Article
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Presynaptic hyperexcitability reversed by positive allosteric modulation of a GABABR epilepsy variant
Brain, awae232, https://doi.org/10.1093/brain/awae232
Published: 19 July 2024
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Reply: Putative benefits of vitamin D supplements in multiple sclerosis out of reach due to sample size Get access
Brain, awae246, https://doi.org/10.1093/brain/awae246
Published: 19 July 2024
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Prioritized modules and their structural preservation across networks. ( A... Get access
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Shared patterns of glial transcriptional dysregulation link Huntington’s disease and schizophrenia
Published: 19 July 2024
Figure 2
Prioritized modules and their structural preservation across networks. ( A ) Nine modules were identified as significantly associated with the condition phenotype in glial progenitor cells (GPCs). These modules were tested for network preservation using NetRep 28 , and the maximal P -value was r
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Our model: dysregulated glial support of glutamatergic synapses reciprocall... Get access
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Shared patterns of glial transcriptional dysregulation link Huntington’s disease and schizophrenia
Published: 19 July 2024
Figure 6
Our model: dysregulated glial support of glutamatergic synapses reciprocally impacts oligodendrocytic and astrocytic maturation in both Huntington’s disease and schizophrenia . ( A ) At the glial progenitor cell (GPC) stage, ADGRL3 is regulated by OLIG2. ( B ) ADGRL3 expression is regulated by T
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Disentangling genetic risks for development and progression of Alzheimer’s disease
Brain, awae237, https://doi.org/10.1093/brain/awae237
Published: 18 July 2024
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The rich information hidden in misspoken discourse
Brain, awae242, https://doi.org/10.1093/brain/awae242
Published: 18 July 2024
Journal Article
Correction to: INPP5K and SIL1 associated pathologies with overlapping clinical phenotypes converge through dysregulation of PHGDH
Brain, awae239, https://doi.org/10.1093/brain/awae239
Published: 18 July 2024
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Combined clinical, structural, and cellular studies discriminate pathogenic and benign TRPV4 variants Get access
Brain, awae243, https://doi.org/10.1093/brain/awae243
Published: 18 July 2024
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Broader anti-EBV TCR repertoire in multiple sclerosis: disease specificity and treatment modulation
Brain, awae244, https://doi.org/10.1093/brain/awae244
Published: 18 July 2024
Journal Article
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The graded multidimensional geometry of phenotypic variation and progression in neurodegenerative syndromes
Brain, awae233, https://doi.org/10.1093/brain/awae233
Published: 17 July 2024
Journal Article
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Putative benefits of vitamin D supplements in multiple sclerosis out of reach due to sample size Get access
Brain, awae238, https://doi.org/10.1093/brain/awae238
Published: 16 July 2024
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Brain inflammation co-localizes highly with tau in mild cognitive impairment due to early-onset Alzheimer’s disease
Brain, awae234, https://doi.org/10.1093/brain/awae234
Published: 16 July 2024
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Customized antisense oligonucleotide-based therapy for neurofilament-associated Charcot-Marie-Tooth disease Get access
Brain, awae225, https://doi.org/10.1093/brain/awae225
Published: 15 July 2024
Journal Article
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Systemic inflammatory markers in ageing, Alzheimer’s disease and other dementias Get access
Brain, awae230, https://doi.org/10.1093/brain/awae230
Published: 15 July 2024
Journal Article
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Inflammation-induced mast cell-derived nerve growth factor: a key player in chronic vulvar pain? Get access
Brain, awae228, https://doi.org/10.1093/brain/awae228
Published: 13 July 2024
