From flat-topped Table Mountain down to the blue waters of Table Bay, Cape Town is simply stunning, but the city doesn't thrive by its looks alone. Proudly multicultural, its flourishing arts, dining, and nightlife scenes are proof of this modern metropolis' creativity and innovative spirit.

South Africa’s most popular tourist destination offers the urban thrills of Cape Town, its adjacent wine country and an aura of the rich political history of South Africa. The Overberg's perfect whale-watching perches provide excitement of a different nature. The Garden Route's lakes and forests and the Klein Karoo's ostrich-farming towns and vineyards present another take on the Cape. For extra kicks, try bungee jumping or cage-diving among Great Whites.

The largest game reserve in South Africa, Kruger National Park is basically a synonym for the word "safari." Home to over 500 bird species, 100 reptiles, nearly 150 mammals, multiple archaeological sites, and a stunningly diversity of trees and flowers, Kruger is the country’s flagship national park. Adventurers can explore the park in a 4x4, take a bush walk or fly above in a hot-air balloon.

The Mediterranean's biggest island is separated from the mainland by the Strait of Messina. A mountainous spot, Sicily's coast and its small islands sit at the foot of volcanoes, including Etna, Stromboli and Vulcano. The Greeks, Romans, Normans and Catalans all left their mark on the island in the form of Byzantine palaces, Gothic castles and Baroque flourishes in capital Palermo. Most larger towns offer interesting museums, but Etna and the Hellenic temples in Agrigento offer particularly unique sights.

A patchwork of vineyards and olive groves, dotted with whitewashed hill towns and sun-bronzed beaches—Italy’s southern heel has no shortage of photogenic landscapes. There are a few surprises, too, including the baroque city of Lecce and the Itria Valley, with its UNESCO-listed trulli houses.

The Zanzibar Archipelago, located in the Indian Ocean 15 miles off the coast of Tanzania, is a breathtaking spot to escape from the world. You’ll enjoy clear, turquoise-blue water; shallow sandbars perfect for wading; and many small, nearly deserted islands virtually unvisited by tourists. Explore the World Heritage Site of Stone Town, Zanzibar City’s old quarter. Or just go beach to beach between tiny fishing villages—each one's better than the next.

Greece is one of those rare places where ancient history is still very much a part of modern life. Visitors are as much drawn to the country’s epic intellectual history as its beauty and charm. Make time for the iconic features of the Acropolis of Athens, which include the Parthenon, the Erechtheion, and the Temple of Athena Nike. Mythology buffs will appreciate Crete, Olympia, Samos, and Naxos for their mythological significance. For a peaceful beach vacation, the island of Santorini is perfect.

The wealth of flora and fauna and opportunities to observe them are unparalleled in the Amazon. Riverboats ply the waters of this fascinating wilderness, home to pink river dolphins, clamorous howler monkeys and raucous toucans. Photograph your adventure, run the rapids or stalk elusive jaguars by night.

East meets West in this sun-soaked state, where Indian culture intertwines with Portuguese influences left over from a 500-year occupation. The beaches have long served as a magnet for serene hedonists. To the north, the tourist-centric scene is prevalent, with an international flair that is now skewing more hip than hippie. Travel south for stretches of unspoiled sand and an escape from large resorts. Temples, mosques and wildlife sanctuaries provide diversions from the beach.

Known by a flotilla of aliases, the Resplendent Isle is one of gorgeous beaches, tea plantations and ancient cities. Scuba dive, visit an elephant orphanage and a lagoon of singing fish, explore dense jungle, shrines and temples. Situated just 20 miles off India, the island formerly known as Ceylon is home to 20 million people and eight World Heritage sites. The country's long, brutal civil war ended in May, 2009, bringing peace, stability and a revival of tourism.