Johannesburg is the place to go to mix big-city culture, shopping, dining and nightlife with outdoor adventures, up-close wildlife encounters and visits to historical sites. Explore caves and nature reserves, or visit a traditional village by day, then enjoy dinner at a hip cafe or five-star restaurant. And if you're a shopper, bring an extra, empty suitcase. With malls, open-air markets and places that blend the two, you'll find plenty of unique souvenirs.

Cape Town glistens at the southern toe of the African continent. Tourist brochure-views at Blaauwberg Beach and Kirstenbosch National Botanical Gardens are within easy driving distance of "The Mother City." The Cape of Good Hope Nature Reserve provides sweeping sea vistas, hiking trails and wildlife encounters. On a more somber note, travellers can visit Robben Island, the prison where Nelson Mandela was held for 27 years.

The Indian and colonial influences in this South African beach city can’t be missed, and the blend of cultures and architecture makes Durban unique in South Africa. Durban’s Golden Mile is a destination for surfers, families and fisherman, due to its blend of natural beauty and modern resort. Major-city attractions abound, making this a good destination for families and couples alike.

Now that casinos have spread in South Africa, Sun City is no longer the only gaming hotspot in the country, but it's still visually dramatic. Located two hours from Johannesburg, it's a sprawling complex of luxury hotels, restaurants and Vegas-style shows on the edge of Pilanesberg Game Reserve.