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Metagenomic analysis of wetland soil reveals diverse interacting extrachromosomal genetic elements (ECEs) associated with the methane-oxidizing archaeon Methanoperedens. Some of these ECEs share features with Borgs but are smaller in size, so they are referred to as mini-Borgs.
Visualizing the stages of herpesvirus nuclear egress in situ using cryoET and subvolume averaging shows how nascent virions pass through the nuclear membrane.
Simultaneous DNA-FISH and multiplexed rRNA-FISH spatially map antimicrobial resistance plasmids and phage with their host taxa in polyspecies human oral biofilm samples, revealing hotspots of genetic exchange or amplification.
Microbial community-scale metabolic modelling predicts person-specific short-chain fatty acid profiles and can be used to estimate the impact of dietary, prebiotic and probiotic interventions.
A combination of metagenomic sequencing and fungal cultivation were used to establish a multi-kingdom collection of 33,804 microbial genomes from the human vaginal microbiome.
This study presents an extensive global compendium of metagenomically derived sequences that will serve as a foundation for understanding the role of viruses in soil ecosystems.
Development of pan-drug resistance and hypervirulence in Rhodosporidiobolus fluvialis are enabled by mutagenesis induced by mammalian body temperature.
Plasmid copy number heterogeneity can be used as a tool to build synthetic microbial populations that adapt to changing environments due to specific plasmid-encoded fitness effects.
Differential cross-reactivity to haemagglutinin of various influenza B viruses shows lineage-specific susceptibility that varies between birth cohorts and was determined by early exposure to specific strains.
Heterodera glycines, a soybean cyst nematode, suppresses microbial plant symbiosis by secreting the HgCht2 enzyme to hydrolyse the key symbiotic signalling molecules, lipochitooligosaccharides.
A dual-functional phage protein can both modulate bacterial host behaviour and promote phage genome packaging, ensuring successful propagation and pointing towards phage therapy applications.
A nematode-trapping fungus uses a dual-function G-protein-coupled receptor for perception of nematode-derived ascarosides for hunting Caenorhabditis elegans.
The stable integration of a 192 kb plasmid into the chromosome of Clostridium acetobutylicum by a synthetic biology approach enables continuous production of n-butanol.
A single-cell transcriptomic resource of 174,531 microbial cells across 2,534 species allows the detection of single-cell-level functional roles in the rumen microbiome.
Klebsiella oxytoca provides protection against Salmonella Typhimurium via toxin-dependent inhibition in nutrient-rich, low-competition environments but switches to substrate-driven competition when nutrients are limited.
The number and diversity of organisms known to produce the environmentally important sulfur compound dimethylsulfoniopropionate (DMSP) is expanded with the discovery of a family of DMSP synthesis enzymes.
Longitudinal multi-omics reveals shifts to the human microbiome across multiple body sites and the associated immune responses during short-term spaceflight.
Monoclonal antibodies from people after natural human parainfluenza virus type 3 infection can protect from infection in vitro and in vivo by targeting both pre-fusion F and haemagglutinin-neuraminidase HN proteins of the virus.