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CRISPRi knockdown of essential genes combined with TnSeq of non-essential genes yields a high-throughput method for bacterial genetic interaction mapping.
MHC class II proteins from humans, pigs, ducks, swans and chickens can serve as alternative receptor for virus entry of H2N2 influenza A viruses. This trait is conserved in Eurasian avian H2 IAV.
Subpopulations of Streptococcus pyogenes CRISPR mutants with overactive CRISPR–Cas activity wax and wane in response to phage infection pressure, enabling phage evasion without requiring a transient response in any one cell.
A live-attenuated SARS-CoV-2 vaccine based on one-to-stop codon modifications can elicit broad, systemic and mucosal immunity, as well as reduced transmission of SARS-CoV-2 in vivo.
Faecal metagenomes and machine learning reveal a panel of 31 multikingdom microbiome markers and microbiome functions that are associated with autism spectrum disorder in male and female children.
A genome-wide CRISPR-based screen of Toxoplasma gondii during mouse infection reveals previously uncharacterized factors contributing to parasite virulence.
Global soil sequencing data and enrichment experiments show trade-offs in denitrification phenotypes driven by pH, underscoring how the environment shapes ecological interactions and gene content.
Enterococcus faecalis-derived adenine increases enterohaemorrhagic Escherichia coli virulence by relieving Hha-dependent repression of Type 3 Secretion System activity.
Metagenomic analysis of wetland soil reveals diverse interacting extrachromosomal genetic elements (ECEs) associated with the methane-oxidizing archaeon Methanoperedens. Some of these ECEs share features with Borgs but are smaller in size, so they are referred to as mini-Borgs.
Visualizing the stages of herpesvirus nuclear egress in situ using cryoET and subvolume averaging shows how nascent virions pass through the nuclear membrane.
Simultaneous DNA-FISH and multiplexed rRNA-FISH spatially map antimicrobial resistance plasmids and phage with their host taxa in polyspecies human oral biofilm samples, revealing hotspots of genetic exchange or amplification.
Microbial community-scale metabolic modelling predicts person-specific short-chain fatty acid profiles and can be used to estimate the impact of dietary, prebiotic and probiotic interventions.
Development of pan-drug resistance and hypervirulence in Rhodosporidiobolus fluvialis are enabled by mutagenesis induced by mammalian body temperature.
Plasmid copy number heterogeneity can be used as a tool to build synthetic microbial populations that adapt to changing environments due to specific plasmid-encoded fitness effects.
Differential cross-reactivity to haemagglutinin of various influenza B viruses shows lineage-specific susceptibility that varies between birth cohorts and was determined by early exposure to specific strains.