Behav. Sci., Volume 12, Issue 2 (February 2022) – 39 articles
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Treatment-resistant depression (TRD) is an ongoing challenge for clinicians, being responsible for high disability and poor social functioning. In the framework of precision medicine, the objective of current research in the field is to find clinical and biological factors associated with this condition. Patients affected by TRD present unfavourable clinical features such as the propensity to suicidal behaviour. The identification of TRD-related changes in biochemical parameters such as bilirubin or neutrophil to lymphocyte ratio initiates the search for new treatment targets. In this context, as regards the enhancement of antioxidative systems, it would be important to understand whether the administration of antioxidant agents could improve some clinical aspects of patients with TRD. View this paper
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