📣 ⚡🔬 🧬 What would you do with 1000+ spatial transcriptomics samples with corresponding H&E-stained whole-slide images? Meet HEST-1k, a collection of 1,108 ST samples assembled from 131 public and internal cohorts encompassing 25 organs, 2 species. HEST-1k includes over 1.5 million expression–morphology pairs. 🔍Explore 3 use-cases for HEST-1k: - HEST-Benchmark: Evaluate gene expression prediction from histology across 10 organs and 9 cancer types, testing multiple foundation models for pathology including UNI, and GigaPath. - HEST for discovery: Explore our proof-of-concept for multimodal biomarker characterization using Xenium breast cancer samples. - HEST for fine-tuning pathology foundation models: See how HEST-1k can enhance foundation models for histology with expression-guided fine-tuning. 📄Preprint: https://lnkd.in/dMQvrJxC 👩💻 Code and Data access: https://lnkd.in/drYbW5xW Congratulations to Guillaume Jaume, Paul Doucet and everyone else who contributed to this work. Huge thanks to everyone who helped curate the dataset. #SpatialTranscriptomics #ComputationalPathology #CancerResearch #Bioinformatics
Wow!
Brilliant work. That is a lot of ST data.
Very interesting
Looks great! :) Jonny Hancox, Daguang Xu
Amazing!
Huge congratulations! Exciting research
CRTA Fellow at NCI/NIH | Data Science | Computational Biology | Machine Learning | Bioinformatics
1wEldad Shulman - might be of your interest!