BioprocessUpdates’ Post

📢 Boosting Microbes for Extreme Conditions: The Winning Formula 📝MIT researchers have developed a method to make microbes more resilient for manufacturing processes and extreme conditions. 💪🔬 🔬 They mixed bacteria with FDA-approved food and drug additives to stabilize different types of microbes. 🦠 🌡️ The formulations showed resistance to high temperatures, radiation, and industrial processing. 💥💊 🚀 The researchers are now analyzing how well these microbes withstand extreme conditions in space. 🌌 💡 This research has implications for human health, agriculture, and space missions. 🌱👩🚀 #BioprocessUpdates #MicrobiomeTherapeutics #Manufacturing #Extremophile #AdditiveCombos #ResilientMicrobes #FDAapproved #StabilizeMicrobes #HighTemperatureResistance #RadiationResistance #IndustrialProcessingResistance #SpaceResearch #HumanHealth #Agriculture #SpaceMissions #MicrobesInSpace ▷ Read the full article here: 📎 https://lnkd.in/dmVZ3JUR

📢 Unveiling AAV Charge Variations: Breakthrough Analysis! 📌 The article "Characterizing AAV Charge Heterogeneity Using High-Resolution icIEF Fractionation with LC-MS Analysis" discusses a method for analyzing the charge heterogeneity of adeno-associated viruses AAVs using high-resolution ion-exchange fractionation and LC-MS analysis. 🧪 This method allows for a more accurate characterization of AAVs and can help in the development of gene therapies. 💡 #BioprocessUpdates #AAV #ChargeHeterogeneity #icIEF #LCMS #Characterization #GeneTherapy #AdenoAssociatedViruses #HighResolutionAnalysis #FractionationMethod #ResearchArticle #ScientificAnalysis #MethodDevelopment #TherapeuticApplications #BiomedicalResearch #AAVAnalysis ▷ Read the full article here: 📎 https://lnkd.in/dtu9EJCr

📢 Novo Holdings A/S and Abingworth have co-led a £90m financing round in Myricx Bio Ltd, a cancer ADC specialist. 🤝 The funding will be used to expand Myricx Bio's ADC platform and advance its pipeline through clinical proof of concept. 💰 Other investors include British Patient Capital and Eli Lilly and Company ✅ Novo Holdings Venture Investments Partner Michael Bauer will join Myricx Bio's Board of Directors. #BioprocessUpdates #NovoHoldings #Abingworth #financing #MyricxBio #cancerADC #specialist #funding #expansion #clinicaltrial #BritishPatientCapital #EliLilly #investors #boardofdirectors #biotech #pharmaceuticals ▷ Read the full article here: 📎 https://lnkd.in/d6gGR5Bt

📢 anacura Expands Services with OHMXbio Acquisition 📢 Anacura, a Ghent-based company, has acquired OHMX.bio, a University spin-off specializing in advanced -omics technology. This expands Anacura's services in drug discovery and diagnostics research. Anacura aims to provide personalized and evidence-based laboratory solutions and strengthen its service offering to the biotech community. OHMX.bio combines multi-omics technologies with bio-informatics for discovery and quality control of biologics and advanced therapy medicinal products. Anacura has over 250 employees in Evergem and Bruges. #BioprocessUpdates #Anacura #Ohmxbio #biotech #drugdiscovery #diagnosticsresearch #laboratorysolutions #advancedtherapy #biologics #omics #bioinformatics #personalizedmedicine #evidencebased #Ghent #Evergem #Bruges ▷ Read the full article here: 📎 https://lnkd.in/dtJHgHXn

📢 Cellular Origins has acquired the ACTIA Group Platform IP for cell therapy manufacturing. 🧪 This acquisition will accelerate the development of Cellular Origins' robotic solution for automated cell therapy manufacturing, Constellation™. 🚀 Constellation combines automation robotics with aseptic fluid-handling technologies to create a scalable system that integrates with existing bioprocessing equipment. 💡 The ACTIA Platform focuses on autologous cell therapy manufacturing and allows for increased capacity and random access to process steps. 👩🔬 This acquisition will help solve the challenge of large-scale cell therapy production. #BioprocessUpdates #CellularOrigins #ACTIAPlatform #CellTherapyManufacturing #RoboticSolution #Constellation #Automation #AsepticFluidHandling #ScalableSystem #BioprocessingEquipment #AutologousCellTherapy #IncreasedCapacity #RandomAccess #LargeScaleProduction #CellTherapyProduction #CellularOriginsAcquisition ▷ Read the full article here: 📎 https://lnkd.in/dqgez8YQ

📢 Discover the Key to Sustainable Practices 📰 According to James Dean Vogel, biomanufacturers are still in early stages of developing sustainable practices. Defining sustainability and its measurement is a key concern. Vogel states that sustainability means different things to different people. Companies may focus on reducing carbon footprint or water use as measures of sustainability. The choice between stainless steel equipment and single-use plastics depends on various factors. Vogel recommends all companies consider sustainability seriously to benefit their bottom line and the planet. #BioprocessUpdates #sustainabilitydecisions #earlystages #biomanufacturers #sustainablepractices #carbonfootprint #wateruse #stainlesssteelequipment #singleuseplastics #benefittheplanet #sustainabilitymeasurement #reducecarbonfootprint #seriouslysustainable #planetfriendly #bottomline #sustainablechoices ▷ Read the full article here: 📎 https://lnkd.in/diHg4VT8

📢 Maximizing Safety and Efficiency in Bioprocessing 🔍 Bioprocessing equipment and products must be sterilized to ensure they are free from microbial contamination. Even a small level of contamination can compromise safety and efficacy. ✅ Manufacturers need to consider sterilization during the design process of equipment to facilitate easier and more effective cleaning and sterilization. ✅ Risk assessment is crucial, and human error must be avoided through good aseptic practices. ✅ Advanced materials that are microbe-resistant can be used in equipment to reduce the risk of contamination. ✅ Automated cleaning and sterilization systems, along with continuous monitoring, help reduce human error. ✨ Sterilization methods are continually being refined to enhance their effectiveness, reduce processing time, and ensure safety. #BioprocessUpdates #bioprocessingclean #sterilization #microbialcontamination #safetyandefficacy #designprocess #easycleaning #riskassessment #asepticpractices #microberesistant #automatedsystems #continuousmonitoring #effectiveness #processingtime #ensuresafety #refinedmethods ▷ Read the full article here: 📎 https://lnkd.in/dCyWgztU

📢 Boosted Growth and Titer: Revolutionary Findings in Green Biopharmaceutical Fermentation 💡 Researchers at University College Dublin UCD have found that supplementing yeast spent media can enhance titer and growth. 🌿 This suggests that a circular green economy is feasible for biopharmaceutical fermentation operations. 🧪 They discovered that adding magnesium and sodium to the spent media improved the growth rate of E. coli and increased protein titer. 🧫 This approach not only increases productivity but also reduces energy use and waste. 👩🔬🌍 #BioprocessUpdates #SupplementationUpsTiter #GrowthofYeastSpentMedia #CircularGreenEconomy #BiopharmaceuticalFermentation #MagnesiumandSodium #IncreaseProductivity #ReduceEnergyUse #ReduceWaste #UCDResearch #EcoliGrowth #ProteinTiter #SustainableScience #GreenResearch #Bioengineering #CircularEconomy ▷ Read the full article here: 📎 https://lnkd.in/dJTVV9pq

📢 10 New Medicines Approved by EMA in June 2024 - Check Them Out Now! 📢 EMA's human medicines committee CHMP recommended ten medicines for approval in June 2024. 🎗️ Balversa erdafitinib was recommended for the treatment of adult patients with urothelial carcinoma. 👃 Eurneffy epinephrine was recommended as the first emergency treatment for allergic reactions in nasal spray form. 💉 mResvia RSV mRNA vaccine received a positive opinion for preventing respiratory syncytial virus in adults. 💊 Ordspono odronextamab was recommended for the treatment of follicular and diffuse large B-cell lymphoma. 🩸 Piasky crovalimab received a positive opinion for paroxysmal nocturnal haemoglobinuria. 🧠 Tauvid flortaucipir was recommended for PET imaging of the brain in patients with cognitive impairment. 🫀 Winrevair sotatercept received a marketing authorisation for treating pulmonary arterial hypertension. 🍀 Steqeyma ustekinumab was recommended for the treatment of Crohn's disease, plaque psoriasis, and psoriatic arthritis. 💊 Enzalutamide Viatris enzalutamide and Nilotinib Accord nilotinib received positive opinions as generic medicines. 🔍 More details in the news announcement on the website. #BioprocessUpdates #EMA #drugrecommendations #Balversa #Eurneffy #mResvia #Ordspono #Piasky #Tauvid #Winrevair #Steqeyma #EnzalutamideViatris #NilotinibAccord #pharmaceuticals #healthnews #genericmedicines ▷ Read the full article here: 📎 https://lnkd.in/d2d9v46g

📢 Revolutionizing Lentiviral Vector Production for Better Therapies 📰 Lentiviral vectors are important tools in cell and gene therapy, but current production processes have room for improvement. 🧬 Scalability, productivity, and process yield are some of the challenges faced in lentiviral vector production. 🔬 Bioprocessing technologies such as high-titer suspension cells and single-use bioreactors can help optimize the production process. 💻 Process control software and artificial intelligence AI can also assist in improving vector quality and efficiency. 🚀 The ultimate goal is to create a robust and easily scalable manufacturing platform to ensure safety and efficacy of therapies. 🔬🧪🧬 #LentiviralVectors #Bioprocessing #CellTherapy #GeneTherapy #AI #BioprocessUpdates #LentiviralVectors #Bioprocessing #CellTherapy #GeneTherapy #AI #Scalability #Productivity #ProcessYield #HighTiterSuspensionCells #SingleUseBioreactors #ProcessControlSoftware #ArtificialIntelligence #VectorQuality #Efficiency #ManufacturingPlatform #SafetyAndEfficacy ▷ Read the full article here: 📎 https://lnkd.in/dhR8dRWV