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TruDiagnostic is featured in the The Wall Street Journal covering the Rejuvenation Olympics along with Bryan Johnson, Siim Land, and other leaders on…
TruDiagnostic is featured in the The Wall Street Journal covering the Rejuvenation Olympics along with Bryan Johnson, Siim Land, and other leaders on…
Posted by Hannah Went
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📣We're thrilled to invite you to #RAADfest2024, the world’s largest event focused on super-longevity!🧬 Join our Founders, Hannah Went and Ryan…
📣We're thrilled to invite you to #RAADfest2024, the world’s largest event focused on super-longevity!🧬 Join our Founders, Hannah Went and Ryan…
Liked by Hannah Went
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https://conta.cc/3VTv6vk These Frozen Steaks are well below Market-Let’s Talk
https://conta.cc/3VTv6vk These Frozen Steaks are well below Market-Let’s Talk
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Experience & Education
Publications
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Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions
Aging-US
Senolytics, small molecules targeting cellular senescence, have emerged as potential therapeutics to enhance health span. However, their impact on epigenetic age remains unstudied. This study aimed to assess the effects of Dasatinib and Quercetin (DQ) senolytic treatment on DNA methylation (DNAm), epigenetic age, and immune cell subsets. In a Phase I pilot study, 19 participants received DQ for 6 months, with DNAm measured at baseline, 3 months, and 6 months. Significant increases in epigenetic…
Senolytics, small molecules targeting cellular senescence, have emerged as potential therapeutics to enhance health span. However, their impact on epigenetic age remains unstudied. This study aimed to assess the effects of Dasatinib and Quercetin (DQ) senolytic treatment on DNA methylation (DNAm), epigenetic age, and immune cell subsets. In a Phase I pilot study, 19 participants received DQ for 6 months, with DNAm measured at baseline, 3 months, and 6 months. Significant increases in epigenetic age acceleration were observed in first-generation epigenetic clocks and mitotic clocks at 3 and 6 months, along with a notable decrease in telomere length. However, no significant differences were observed in second and third-generation clocks. Building upon these findings, a subsequent investigation evaluated the combination of DQ with Fisetin (DQF), a well-known antioxidant and antiaging senolytic molecule. After one year, 19 participants (including 10 from the initial study) received DQF for 6 months, with DNAm assessed at baseline and 6 months. Remarkably, the addition of Fisetin to the treatment resulted in non-significant increases in epigenetic age acceleration, suggesting a potential mitigating effect of Fisetin on the impact of DQ on epigenetic aging. Furthermore, our analyses unveiled notable differences in immune cell proportions between the DQ and DQF treatment groups, providing a biological basis for the divergent patterns observed in the evolution of epigenetic clocks. These findings warrant further research to validate and comprehensively understand the implications of these combined interventions.
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Epigenetic clocks and risk assessment in adult spinal deformity: A novel association between pace of aging with frailty, disability, and postoperative complications
Journal of Neurosurgery
Michael M. Safaee MD, Varun B. Dwaraka PhD, Justin M. Lee BA, Marissa Fury BS, Tavis L. Mendez PhD, Ryan Smith BS, Jue Lin PhD, Dana L. Smith MS, John F. Burke MD, Justin K. Scheer MD, Hannah Went BS, Christopher P. Ames MD. (In review) Epigenetic clocks and risk assessment in adult spinal deformity: A novel association between pace of aging with frailty, disability, and postoperative complications. medRxiv
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Longitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA Vaccination
Frontiers
Pang APS, Higgins-Chen AT, Comite F, Raica I, Arboleda C, Went H, Mendez T, Schotsaert M, Dwaraka V, Smith R, Levine ME, Ndhlovu LC and Corley MJ (2022) Longitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA Vaccination. Front. Genet. 13:819749. doi: 10.3389/fgene.2022.819749
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Effects of homogenizing methods on accuracy and precision of equine strongylid egg counts.
Veterinary Parasitology
Went, H.A. “Effects of homogenizing methods on accuracy and precision of equine strongylid egg counts.” Veterinary Parasitology, vol. 261, 15 Sept. 2018. pp. 91-95.
More activity by Hannah
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First Look At The Next YT video! Which Nutrients Are Associated With A Younger Brain Age? https://lnkd.in/eE7R-CkS
First Look At The Next YT video! Which Nutrients Are Associated With A Younger Brain Age? https://lnkd.in/eE7R-CkS
Liked by Hannah Went
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Thanks for being on the podcast, Andrew DiNardo!
Thanks for being on the podcast, Andrew DiNardo!
Shared by Hannah Went
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updated news in epigenetics! TruDiagnostic launches SYMPHONYAge, the world's first organ-specific aging analysis. Developed by Yale scientists…
updated news in epigenetics! TruDiagnostic launches SYMPHONYAge, the world's first organ-specific aging analysis. Developed by Yale scientists…
Liked by Hannah Went
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TruDiagnostic has developed epigenetic aging analysis of individual #organsystems, using validated and system-specific trained clocks. #healthcare…
TruDiagnostic has developed epigenetic aging analysis of individual #organsystems, using validated and system-specific trained clocks. #healthcare…
Liked by Hannah Went
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E.505: Join us for an episode with the founder of Everything Epigenetics as we explore this complex topic and its emergence into the realm of the…
E.505: Join us for an episode with the founder of Everything Epigenetics as we explore this complex topic and its emergence into the realm of the…
Liked by Hannah Went
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Job posting!! Comfortable Living, is passionate about improving the quality of life for individuals with Acquired Brain Injuries and Developmental…
Job posting!! Comfortable Living, is passionate about improving the quality of life for individuals with Acquired Brain Injuries and Developmental…
Shared by Hannah Went
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