Mark Pruzanski, MA, MD

Our partner Eddie Eltoukhy has identified these opportunities in Biotech. Eddie has a PhD in bioengineering from Massachusetts Institute of Technology and over a decade experience as an operator. Reach out to him if you are working on these areas of biotech. Pear VC - Technology-Driven Therapeutic Platforms Companies developing therapeutic assets with a core product engine Proprietary tool, workflow, or samples leading to novel biological data sets Preference for omics platforms or high throughput screening / engineering workflows First-in-class or best-in-class drugs - Next-Generation Therapeutic Modalities Technologies to improve the efficacy, safety, access, or reach of next-gen modalities including the following: Genomic medicines (gene tx & gene editing) Cell therapies Targeted protein degraders Antibody-drug conjugates Radiopharma - Precision Medicine New technologies supporting the discovery of novel biomarkers and the generation of proprietary data sets for applications in: Disease screening Therapy selection Recurrence monitoring - Life Sciences + AI Software Platforms Software & AI-driven platforms to improve all aspects of life sciences R&D, including: Target discovery and validation Drug design and optimization Manufacturing Regulatory Clinical development

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Looking back at the past 30 years, I remember myself doing science about 55-60 hours a week, and then helping venture capitalists and biotech start-ups about 70-80 h/week. Usually unsatisfied, sometimes exhausted, but pleased overall. This overexciting workaholism was somehow interrupted last year. I had less work and a lot of mountaineering, - climbed about 5.5 Chomolungma attitudes during the year. It feels like I have reached the stage at which it is a time to start sharing experiences and understanding of the universe. This week, I started to share by publishing an analytic report at SeekigAlpha about TG Therapeutics. This small biotech company has developed a third-to-market anti-CD20 mAb for the treatment of multiple sclerosis (MS). Along with the company, this report briefly touches upon current treatments for MS, the competitive landscape of therapeutics, and the uncertainties surrounding the development of new BTK inhibitors. https://lnkd.in/drAFx9vt

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The healthcare landscape is rapidly evolving, driven by advancements in technology and a deeper understanding of patient care. I had the pleasure of speaking with Ambar Bhattacharyya, Co-Managing Partner at Maverick Ventures, on the latest episode of The Full Ratchet. Ambar has partnered with numerous billion-dollar companies like hims & hers, Cityblock Health, Devoted Health, and ConcertAI. His unique journey from rural America to becoming a prominent figure in venture capital offers invaluable insights into the future of healthcare and technology. We discuss his investment strategy at Maverick Ventures, the megatrends shaping healthcare, the impact of AI on the industry, and the importance of integrated care. Ambar also shares his thoughts on the challenges and opportunities in healthcare investment, offering a comprehensive view of what lies ahead. Check out TFR Episode 438 to catch our conversation. You'll be glad you listened.

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Abby Levy talks about venture's role in US healthcare and what we can expect to see as technology impacts the space on TFR. Check out the rest of the conversation with Abby & Alan Patricof of Primetime Partners on Episode 433.

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This week Mikal Ventures brings you a 4-week breakdown of the US capital market with an emphasis on the Mikal verticals. Over the 4-week period ending April 15, just over 900 new companies were added, with 94,109 companies included in the US Health Tech, Med Tech, Fin Tech, AI Tech, and Ed Tech verticals. AI Tech again saw the greatest percentage of growth in new companies and transactions, weighing in at over double the vertical averages for the period. The US Fin Tech vertical again led the way in SEC Filings and news articles. Mikal Ventures publishes these stats on a rolling 4-week basis to provide a perspective on how the verticals and new startups move through time. We hope you find them informative and thought-provoking. VC Investors are always adjusting their "Play Book" with a variety of options for investing. Mikal Ventures is one of those alternatives, offering curated solutions to real world problems. Reach out if you have questions on how we can be of assistance and bookmark https://mikalventures.com/ for additional insights and information.

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An investment memo on Laverock Therapeutics. This memo is for research purposes and reflects my interest in writing an investment blog. It should not be considered a recommendation for investment. I have no financial interest or gain from the company discussed, which was selected randomly for my series of memos. I plan to write one or two such memos every month. As this is for personal writing, I do not provide recommendations on investment amounts or deal summaries and hence I have not created exit scenarios analysing different outcomes with multiple probabilities, returns, and the Multiple of Invested Capital (MOIC) as is typical in some investment memos. #investmentmemo #biotech #lifesciences #investment #personalnarrative

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This will be a fascinating SynBioBeta talk - on how the combined tools of synthetic biology allowed Creyon Bio to build a successful drug in a few months 😳

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At Two Bear Capital our definition of value-add, lead, early-stage investing is to form a true partnership with the founders we back. We believe that only a small fraction of our return potential comes from us “picking right” when we make our first investment into a company – the vast majority comes from how effectively we can actively help our brilliant founders over the ensuing 3-7 years in achieving the passionate, ambitious, and positive-impact goals that drive them.

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The opioid crisis was a sad hallmark of my years working for the Baker Administration. In a time of extreme partisanship at the federal level, this was one area where public policy, civil discourse, and private enterprise seemed aligned and sufficiently motivated to find a solution. What we learned, however, is that dollars and access only go so far in combatting a disease that knows no so specific demographic. Instead, it's apparent that a battery of tools is needed to combat and prevent addiction--ranging from strong safety nets, to novel non-addictive pain therapies, and better technology. Introducing Marigold Health. Shrenik Jain, Ravi Shah, Tracey Cohen, MD, FASAM and team have built a proprietary NLP-based platform that--most significantly--improves the lives of those suffering from SUD/SMI. One customer we spoke with noted, "We needed a unique treatment intervention that had supportive research, fit into a CMS established model with a recognized service code, and that would provide positive clinical outcomes in an efficacious and fiscally responsible manner”. Another plainly said: "Marigold is our best hope to reach into the lives and help those who many have already given up on." Honored to join Bill Evans, Sean Day, and the entire syndicate in doing our part to scale a tool we believe will become essential in the fight against addiction. Marigold Health Innospark Ventures Rock Health KdT Ventures Matt Fates Lily Zarrella Venkat Srinivasan

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Discover 10 big pharma and biotech companies that have spun out their own venture capital arms to invest in startups in the industry. #venturecapital #veteranventures

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 📣Join Our Mission: Women's Health! Despite recent growth in the women’s health space, there is still unmet demand for products and services. Menopause has been a particularly overlooked segment of the market: only 5 percent of FemTech start-ups address menopause needs globally (McKinsey & Company, 2024). Nevertheless, the acceleration of advances in women’s healthcare holds considerable implications for investors and stakeholders across the value chain and beyond. At KRING, we're pioneering innovative solutions in women's health, focusing on cognitive health, sleep management, menopause, fertility, and more - with Menopause, an active health challenge we are currently exploring. While diving into Validation, our concept has garnered significant interest across the health innovation ecosystem, corporate partners, and investors. ✅ Chief Commercial Officer (Co-founder) We're seeking dynamic Commercial Co-founders with robust entrepreneurial backgrounds with experience of scratch to commercialization, and exceptional leadership skills. Experience in negotiating complex agreements is advantageous, but a passion for women's health is essential. https://lnkd.in/dVRwJ6i8 ✅ Menopause Expert: Chief Product Officer (Co-founder) We're looking for a scientific expert with a deep understanding of medical science, clinical research, and regulatory requirements, to lead the development of innovative healthcare solutions for women's health. https://lnkd.in/dXX3RWQY 🧠 The Concept: Building a Digital Platform for Women's Health Our digital platform helps women tackle midlife challenges, including menopause, by enhancing sleep quality, addressing weight gain, and boosting self-confidence. Components include data gathering, tailored recommendations, personalized wellness programs, and a supportive community. 📍Join Us in Copenhagen Our team is headquartered in Copenhagen, offering an exciting opportunity for individuals based in these cities or open to relocation. If you're intrigued by this opportunity, we'd love to hear from you. Reach out to Marina Miteva and Agnes A. to learn more. Join Entrepreneurs, Innovators, and Investors like Britt Meelby Jensen, Kristine Leerbeck, Christina Høgh Selmer Kirk, Anne Mette Bang, Benjamin Suhr, Anja Monrad, Sonal Pendharkar Kulkarni, Ella Smoraczewska Harris, Fanny Hauterat, Sumeya Hassan, Rosemarie Wedell-Wedellsborg, Jane Kudsk, Susanne Brønnum, Pernille Foss, Sara Maria Franch-Mærkedahl, Gitte Nipper, Jenny-Ann Axson Johnson, and more in revolutionizing healthcare and shaping the future of women's health. Apply now.

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The FDA greenlighted one of our portfolio companies to move a novel antidepressant drug to Phase 2a clinical trial! I am excited to share important positive news from Freedom Biosciences, a San Francisco-based clinical-stage biotech we have invested in via LongeVC back in 2023. The company has just announced FDA approval of investigational new drug (IND) application for their FREE001 Phase 2a program in patients with treatment-resistant depression (TRD). Freedom Bio plans to initiate its Phase 2a clinical trial in the first half of this year, which has the potential to address a critical unmet medical need in patients suffering from TRD. FREE001 is a ketamine-based combination therapy for the treatment of TRD, which builds on John Krystal work in Yale University. He showed that the combination may extend the antidepressant effects of ketamine from 2-7 days up to 2 to 3 weeks. Major depressive disorder (MDD) is a debilitating and chronic condition with limited effective treatment options, and Freedom Bio tries to tackle its specific case, treatment-resistant depression, when a person diagnosed with MDD does not respond adequately to a course of appropriate antidepressant medication within a certain time frame. MDD is one of the most common mental health disorders in the United States (US), with an estimated 21.0 million adults (8.3% of all adults) having at least 1 major depressive episode in 2020 (link to statistics in the comments). MDD also impacts physical health, worsens outcomes of other medical conditions, and, on average, results in a 10-year reduction in life expectancy. I am inspired by the achievements of Dina Burkitbayeva and Freedom Bio’s team in this truly challenging and notoriously hard area of drug discovery! Way to go, folks. #neuroscience #drugdiscovery #FDA

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In Episode 3 of the "Brain Cancer Science Talk" series on #MissionGBM, we chat with John de Groot, MD (Division Chief of Neuro-Oncology, UCSF) about immunotherapies, the need for combination protocols, Focused Ultrasound, and necessary improvements to clinical trial design and Regulatory framework to advance the development of treatment options for #braincancer patients. #FUS #ImmunoOncology #GBM #Onward #Nof1onBehalfofAll

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This week Mikal Ventures brings you a 4-week breakdown of the US capital market with an emphasis on the Mikal verticals. Over the 4-week period ending June 10, just over 590 new companies were added, resulting in 95,661 companies included in the US Health Tech, Med Tech, Fin Tech, AI Tech, and Ed Tech verticals. AI Tech maintained its most active status, seeing the greatest percentage of growth in both new companies and transactions. The US Fin Tech vertical led the way in SEC Filings and news articles. Mikal Ventures publishes these stats to provide a perspective on how the verticals and new startups move through time. We hope you find them informative and thought-provoking. VC Investors are always adjusting their "Play Book" with a variety of options for investing. Mikal Ventures is one of those alternatives, offering curated solutions to real world problems. Reach out if you have questions on how we can be of assistance and bookmark https://mikalventures.com/ for additional insights and information.

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I love this! Thank you to Rachel Brown from Beauty Independent to kick-off this exchange with Andrew Ross' provocative thesis and have us all react to it. I truly enjoyed reading everyone's thoughts on the topic of the shortening lifecycle of beauty brands. Here is a snippet of mine: "Because beauty brand lifespans are shortening, it is important that we are able to differentiate brands with staying power from brands that will end up being a flash in the pan. There are much more of the latter than the former in the market right now, and if a brand is not well-positioned, it will be challenging for that brand to survive over the long-term. That’s why we focus on understanding each brand’s differentiators and long-term relevance." See more here: https://lnkd.in/esVbwnu2 and you will discover what Kevin Murphy, Odile Roujol, Rich Gersten, Tina Henry Bou-Saba, Oliver Nordlinger, Claire Chang, Manica Blain, Sonya Brown, George Birman had to say. #beautyindustry #beautyinvesting Stride Consumer Partners

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This week Mikal Ventures brings you a 2-week breakdown of the US capital market with an emphasis on the Mikal verticals. Over the 2-week period ending May 13, 450 new companies were added, with just under 95,000 companies included in the US Health Tech, Med Tech, Fin Tech, AI Tech, and Ed Tech verticals. AI Tech again saw the greatest percentage of growth in new companies and transactions, weighing in at over double the vertical averages for the period. The US Med Tech vertical led the way in SEC Filings, with Fin Tech leading in news articles. Mikal Ventures publishes these stats to provide a perspective on how the verticals and new startups move through time. We hope you find them informative and thought-provoking. VC Investors are always adjusting their "Play Book" with a variety of options for investing. Mikal Ventures is one of those alternatives, offering curated solutions to real world problems. Reach out if you have questions on how we can be of assistance and bookmark https://mikalventures.com/ for additional insights and information.

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From 2 to 90 customers and $800k to $6M ARR since leading their Series A just over a year ago, Hydrolix's growth speaks for itself. And this is just the beginning! Proud that Nava Ventures is joining forces with industry leaders like S3 Ventures (Aaron Perman), AV8 Ventures (Baris Aksoy), Wing Venture Capital (Peter Wagner), and Oregon Venture Fund (Matt Compton and Scott Grout) in this heavily oversubscribed Series B. Here's to Marty Kagan and the Hydrolix team, pioneering a new era in data observability within the enterprise! Check out the announcements in the comments

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Is private equity owned healthcare a positive or a negative in regard to real health outcomes for patients? I asked Ambar Bhattacharyya of Maverick Ventures this question and more on Episode 438 of The Full Ratchet. Tune into the show to catch our discussion.

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Good for the entire ecosystem

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