About
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The goal of our Open Innovation Team is to partner with the best in different fields to help us propel to our ambitions for the future of beauty…
The goal of our Open Innovation Team is to partner with the best in different fields to help us propel to our ambitions for the future of beauty…
Shared by Guive Balooch
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Docusign was just named the #1 Most Trusted Software company in America by Newsweek! We are humbled to have the confidence of our customers to earn…
Docusign was just named the #1 Most Trusted Software company in America by Newsweek! We are humbled to have the confidence of our customers to earn…
Liked by Guive Balooch
Experience & Education
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L'Oréal
View Guive’s full experience
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Volunteer Experience
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Volunteer
Upwardly Global
- 7 years 1 month
Helping foreign professionals with advanced degrees (MD, PhD, MBA) coming from countries outside of the USA to find jobs in the US market.
Publications
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Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling.
Development
See publicationList of Authors:
Cyril C Charles, Maria M Hovorakova, Youngwook Y Ahn, David B DB Lyons, Pauline P Marangoni, Svatava S Churava, Brian B Biehs, Andrew A Jheon, Hervé H Lesot, Guive G Balooch, Robb R Krumlauf, Laurent L Viriot, Renata R Peterkova, Ophir D OD Klein -
Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-β and Runx2 is required for hearing
EMBO Reports
Physical cues, such as extracellular matrix stiffness, direct cell differentiation and support tissue-specific function. Perturbation of these cues underlies diverse pathologies, including osteoarthritis, cardiovascular disease and cancer. However, the molecular mechanisms that establish tissue-specific material properties and link them to healthy tissue function are unknown. We show that Runx2, a key lineage-specific transcription factor, regulates the material properties of bone matrix…
Physical cues, such as extracellular matrix stiffness, direct cell differentiation and support tissue-specific function. Perturbation of these cues underlies diverse pathologies, including osteoarthritis, cardiovascular disease and cancer. However, the molecular mechanisms that establish tissue-specific material properties and link them to healthy tissue function are unknown. We show that Runx2, a key lineage-specific transcription factor, regulates the material properties of bone matrix through the same transforming growth factor-β (TGFβ)-responsive pathway that controls osteoblast differentiation. Deregulated TGFβ or Runx2 function compromises the distinctly hard cochlear bone matrix and causes hearing loss, as seen in human cleidocranial dysplasia. In Runx2+/− mice, inhibition of TGFβ signalling rescues both the material properties of the defective matrix, and hearing. This study elucidates the unknown cause of hearing loss in cleidocranial dysplasia, and demonstrates that a molecular pathway controlling cell differentiation also defines material properties of extracellular matrix. Furthermore, our results suggest that the careful regulation of these properties is essential for healthy tissue function.
Other authors -
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Pharmacologic inhibition of the TGF-beta type I receptor kinase has anabolic and anti-catabolic effects on bone
PLoS One
See publicationList of Authors: Khalid S Mohammad, Carol G Chen, Guive Balooch, Elizabeth Stebbins, C Ryan McKenna, Holly Davis, Maria Niewolna, Xiang Hong Peng, Daniel H N Nguyen, Sophi S Ionova-Martin, John W Bracey, William R Hogue, Darren H Wong, Robert O Ritchie, Larry J Suva, Rik Derynck, Theresa A Guise, Tamara Alliston
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TGF-β regulates the mechanical properties and composition of bone matrix
PNAS
The characteristic toughness and strength of bone result from the nature of bone matrix, the mineralized extracellular matrix produced by osteoblasts. The mechanical properties and composition of bone matrix, along with bone mass and architecture, are critical determinants of a bone's ability to resist fracture. Several regulators of bone mass and architecture have been identified, but factors that regulate the mechanical properties and composition of bone matrix are largely unknown. We used a…
The characteristic toughness and strength of bone result from the nature of bone matrix, the mineralized extracellular matrix produced by osteoblasts. The mechanical properties and composition of bone matrix, along with bone mass and architecture, are critical determinants of a bone's ability to resist fracture. Several regulators of bone mass and architecture have been identified, but factors that regulate the mechanical properties and composition of bone matrix are largely unknown. We used a combination of high-resolution approaches, including atomic-force microscopy, x-ray tomography, and Raman microspectroscopy, to assess the properties of bone matrix independently of bone mass and architecture. Properties were evaluated in genetically modified mice with differing levels of TGF-β signaling. Bone matrix properties correlated with the level of TGF-β signaling. Smad3+/– mice had increased bone mass and matrix properties, suggesting that the osteopenic Smad3–/– phenotype may be, in part, secondary to systemic effects of Smad3 deletion. Thus, a reduction in TGF-β signaling, through its effector Smad3, enhanced the mechanical properties and mineral concentration of the bone matrix, as well as the bone mass, enabling the bone to better resist fracture. Our results provide evidence that bone matrix properties are controlled by growth factor signaling.
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Patents
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Cosmetic Compositions containing at least one hydrotope and at lest one active compound
Issued EU
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Cosmetic compositions for increasing bioavailability of the active compounds baicalin and/or vitamin C
Issued EU 9018177
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Systems and Methods for Measuring Spectra of Skin and Other Objects and Materials and Making Predictions Based Thereon
Issued US 20150085279
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