Cold Spring Harbor Laboratory Press

New article in Genes & Development explores how the oocyte-specific protein PADI6 controls DNA methylation essential for early embryogenesis. Access this article at the G&D Stem Cell Collection, and learn more about submitting your own research: bit.ly/GD_StemCells

The new issue of Genome Research is now live. Follow the link to new research describing a harmonized resource of diverse human genomes, a review on cat genomes, and more. https://lnkd.in/dEqXBk_Q

Debate surrounds the function of the most abundant modified nucleotide in mRNA, m6A, and the m6A-binding proteins YTHDF1, 2, and 3. This Perspective from the #RNASpecialIssue examines the emerging data, and our changing understanding of YTHDF proteins and the function of m6A. bit.ly/3UvuVqr #RNAEpitranscriptomics

New methods for high-throughput Nm mapping have been developed in recent years, but challenges remain in accurate mapping and manipulation of Nm to understand its function and disease relevance http://bit.ly/4aUERje #RNASpecialIssue #RNAEpitranscriptomics

In the realm of plant epitranscriptomics, N6-methyladenosine is recognized as the most widespread and extensively studied internal RNA modification found across diverse plant species. This paper highlights its functional mechanisms governing gene expression regulation, and summarizes recent studies regarding its critical roles in plant development, environmental stress response, and crop trial implication. Access now: bit.ly/3UzT9A4 #RNASpecialIssue #RNAEpitranscriptomics

NaBH4 reduction of m1A improves the mutation and readthrough rates in reverse transcription, while promoted Dimroth rearrangement enhances conversion of m1A to m6A, allowing efficient m1A detection in human tRNAs http://bit.ly/3xMLyFb #RNASpecialIssue #RNAEpitranscriptomics

This perspective from the #RNASpecialIssue provides a detailed discussion on how A-to-I editing by ADARs can affect the structure and stability of mRNAs, thereby regulating mRNA function. http://bit.ly/49SuqLq #RNAEpitranscriptomics #ADARs

Multifaceted roles of RNA editing enzyme ADAR1 in innate immunity The latest article from the #RNASpecialIssue explores the genetic and mechanistic evidence for ADAR1’s multipronged role in suppressing dsRNA-mediated autoimmunity, and the evolving roles of ADAR1 as an immuno-oncology target. Access now: bit.ly/49Qf9e3 #RNAEpitranscriptomics #ADAR1

Challenges to mapping and defining m6A function in viral RNA The latest article from the #RNASpecialIssue describes challenges to defining the function of m6A in viral RNA molecules, and provides a framework for future studies to understand how m6A regulates viral infection. Access now: bit.ly/3xY1vZ4 #RNAEpitranscriptomics #ViralRNA #m6A

The presence of 5-methylcytosine as a sparse internal modification of mRNA was first mapped during the epitranscriptomics ‘big bang’ in 2012. Better sequencing and bioinformatic tools now give confidence in the presence of several hundred 5-methylcytosine sites in mRNAs. This article summarizes the status quo of the field, outlines some of its current challenges, and suggests how to address them in future work: bit.ly/49TFb09 #RNASpecialIssue #RNAEpitranscriptomics #ProteinSynthesis