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Serotonin effects on human iPSC-derived neural cell functions: from mitochondria to depression
Depression’s link to serotonin dysregulation is well-known. The monoamine theory posits that depression results from impaired serotonin activity,...
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Serotonin syndrome: a rare undiagnosed cause of hyperpyrexia
Serotonin syndrome (SS) is a rare but potentially life-threatening condition, and it is caused by increasing serotonergic activities. It is an...
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Poorer aging trajectories are associated with elevated serotonin synthesis capacity
The dorsal raphe nucleus (DRN) is one of the earliest targets of Alzheimer’s disease-related tau pathology and is a major source of brain serotonin....
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Serotonin transporter binding in major depressive disorder: impact of serotonin system anatomy
Serotonin transporter (5-HTT) binding deficits are reported in major depressive disorder (MDD). However, most studies have not considered serotonin...
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Comparable roles for serotonin in rats and humans for computations underlying flexible decision-making
Serotonin is critical for adapting behavior flexibly to meet changing environmental demands. Cognitive flexibility is important for successful...
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LC-derived excitatory synaptic transmission to dorsal raphe serotonin neurons is inhibited by activation of alpha2-adrenergic receptors
In the central nervous system, noradrenaline transmission controls the degree to which we are awake, alert, and attentive. Aberrant noradrenaline...
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Serotonin reuptake inhibition for the prevention of vasovagal syncope: a systematic review and meta-analysis
PurposeVasovagal syncope is a common clinical condition that lacks effective medical therapies despite being associated with significant morbidity....
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Neuroleptic malignant syndrome and serotonin syndrome: a comparative bibliometric analysis
ObjectiveThis study aimed to analyze and map scientific literature on Neuroleptic Malignant Syndrome (NMS) and Serotonin Syndrome (SS) from...
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Clinical and Laboratory Factors Related to Seizure and Serotonin Toxicity in Tramadol Intoxication: An Egyptian Study
Background and ObjectivesTramadol is a centrally acting analgesic with a lower risk of addiction compared to opioids. Tramadol overdose is becoming a...
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The Role of the Serotonin Pathway of Tryptophan Metabolism in the Development of Neuroinflammation in Alzheimer’s Disease
AbstractDespite the fact that more than 90% of tryptophan is metabolized via the kynurenine pathway, the serotonin pathway is of great importance for...
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The ‘PSILAUT’ protocol: an experimental medicine study of autistic differences in the function of brain serotonin targets of psilocybin
BackgroundThe underlying neurobiology of the complex autism phenotype remains obscure, although accumulating evidence implicates the serotonin system...
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Analgesic effects of oral Yokukansan on acute postoperative pain and involvement of the serotonin nervous system: a mouse model study
BackgroundYokukansan, a traditional Japanese medicine (Kampo), has been widely used to treat neurosis, dementia, and chronic pain. Previous in vitro...
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Association of serotonin receptor gene polymorphisms with anorexia nervosa: a systematic review and meta-analysis
PurposeSeveral studies have investigated the association between anorexia nervosa and polymorphisms of genes regulating serotonin neurotransmission,...
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Beyond the serotonin deficit hypothesis: communicating a neuroplasticity framework of major depressive disorder
The serotonin deficit hypothesis explanation for major depressive disorder (MDD) has persisted among clinicians and the general public alike despite...
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The serotonin theory of depression: a systematic umbrella review of the evidence
The serotonin hypothesis of depression is still influential. We aimed to synthesise and evaluate evidence on whether depression is associated with...
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Impact of genetic variants within serotonin turnover enzymes on human cerebral monoamine oxidase A in vivo
Variants within the monoamine oxidase A (MAO-A, MAOA ) and tryptophan hydroxylase 2 (TPH2 ) genes, the main enzymes in cerebral serotonin (5-HT)...
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Investigation of the effect of Ramadan fasting on serum levels of melatonin, cortisol, and serotonin: the case of Turkey
IntroductionThe aim of this study is to examine the effects of Ramadan fasting on melatonin, cortisol, and serotonin levels.
MethodsIn this study,...
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General and anxiety-linked influences of acute serotonin reuptake inhibition on neural responses associated with attended visceral sensation
Ordinary sensations from inside the body are important causes and consequences of our affective states and behaviour, yet the roles of...
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Regulation of social hierarchy learning by serotonin transporter availability
Learning one’s status in a group is a fundamental process in building social hierarchies. Although animal studies suggest that serotonin (5-HT)...
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Effect modification of tumor necrosis factor-α on the kynurenine and serotonin pathways in major depressive disorder on type 2 diabetes mellitus
Major depressive disorder (MDD) is strongly associated with type 2 diabetes mellitus (T2DM). The kynurenine and serotonin pathways, as well as...
