Abstract
Introduction
The aim of this study is to examine the effects of Ramadan fasting on melatonin, cortisol, and serotonin levels.
Methods
In this study, the blood of 19 healthy male individuals between the ages of 26 and 51, registered in Agri (Turkey) Family Health Center and fasting during Ramadan, was studied. The study was carried out in 2021–2022. The SPSS-22 package program was used in the analysis of the data. Wilcoxon analysis was used in the study.
Results
It was determined that the pre-test-post-test melatonin and cortisol levels of the individuals were not statistically significant (p>0.05). It was determined that the pre-test-post-test serotonin difference of the individuals was statistically significant (p<0.05).
Conclusion
It has been determined that Ramadan fasting increases the serotonin level of individuals but does not change the levels of melatonin and cortisol. It was determined that the level of happiness of individuals increased after Ramadan fasting. Longitudinal studies on the effects of Ramadan fasting are recommended.
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Data availability
Data may be used with permission from the authors.
References
Trepanowski JF, Bloomer RJ (2010) The impact of religious fasting on human health. Nutr J 9:1–9
Stockman M, Thomas D, Burke J, Apovian CM Intermittent fasting: is the wait worth the weight. 172-185
Venegas-Borsellino C, Sonikpreet Martindale RG (2018) From religion to secularism: the benefits of fasting. Curr Nutr Rep 7:131–138
Kawakami R, Sunaga H, Iso T et al (2022) Ketone body and FGF21 coordinately regulate fasting-induced oxidative stress response in the heart. Sci Rep 12:7338
Zang B-Y, He L-X, Xue L (2022) Intermittent fasting: potential bridge of obesity and diabetes to health? Nutrients 14:981
Visioli F, Mucignat-Caretta C, Anile F, Panaite S-A (2022) Traditional and medical applications of fasting. Nutrients 14:433
Hassanein M, Al-Arouj M, Hamdy O et al (2017) Diabetes and Ramadan: practical guidelines. Diabetes Res Clin Pract 126:303–316
Ahmed HB, Allouche E, Bouzid K et al (2022) Impact of Ramadan fasting on lipid profile and cardiovascular risk factors in patients with stable coronary artery disease. In: Annales de Cardiologie et d’Angéiologie, vol 1. Elsevier, pp 36-40
Patterson RE, Sears DD (2017) Metabolic effects of intermittent fasting. Annu Rev Nutr 37
Posadzki PP, Bajpai R, Kyaw BM et al (2018) Melatonin and health: an umbrella review of health outcomes and biological mechanisms of action. BMC Med 16:1–18
Scarinci E, Tropea A, Notaristefano G et al (2019) “Hormone of darkness” and human reproductive process: direct regulatory role of melatonin in human corpus luteum. J Endocrinol Invest 42:1191–1197
Nous A, Engelborghs S, Smolders I (2021) Melatonin levels in the Alzheimer’s disease continuum: a systematic review. Alzheimer’s Res Ther 13:1–12
Katsu Y, Baker ME (2021) Cortisol. In: Handbook of hormones. Elsevier, pp 947-949
Gardner DG, Shoback DM (2017) Greenspan’s basic and clinical endocrinology. McGraw-Hill Education
Jones LA, Sun EW, Martin AM, Keating DJ (2020) The ever-changing roles of serotonin. Int J Biochem Cell Biol 125:105776
De Deurwaerdere P, Di Giovanni G (2021) 5-HT interaction with other neurotransmitters: an overview. Prog Brain Res 259:1–5
Giniatullin R (2021) Serotonin in migraine: the puzzling role of ionotropic 5-HT 3 receptor in the context of established therapeutic effect of metabotropic 5-HT 1 subtypes. Br J Pharmacol
Almeneessier AS, Bahammam AS, Sharif MM et al (2017) The influence of intermittent fasting on the circadian pattern of melatonin while controlling for caloric intake, energy expenditure, light exposure, and sleep schedules: a preliminary report. Ann Thorac Med 12:183
Besbes A, Khemiss M, Bragazzi N, Ben Saad H (2022) The Impacts of Ramadan intermittent fasting on saliva flow-rate and metabolic data: a systematic review. Front Nutr 9:576
Bahammam A (2004) Effect of fasting during Ramadan on sleep architecture, daytime sleepiness and sleep pattern. Sleep Biol Rhythms 2:135–143
Roky R, Houti I, Moussamih S et al (2004) Physiological and chronobiological changes during Ramadan intermittent fasting. Ann Nutr Metab 48:296–303
Selmaoui B, Touitou Y (2003) Reproducibility of the circadian rhythms of serum cortisol and melatonin in healthy subjects: a study of three different 24-h cycles over six weeks. Life Sci 73:3339–3349
Brzezinski A (1997) Melatonin in humans. N Engl J Med 336:186–195
Berga SL, Loucks TL, Cameron JL (2001) Endocrine and chronobiological effects of fasting in women. Fertil Steril 75:926–932
Al-Hadramy M, Zawawi T, Abdelwahab S (1988) Altered cortisol levels in relation to Ramadan. Eur J Clin Nutr 42:359–362
Bahijri S, Borai A, Ajabnoor G et al (2013) Relative metabolic stability, but disrupted circadian cortisol secretion during the fasting month of Ramadan. PLoS ONE 8:e60917
McAllister MJ, Pigg BL, Renteria LI, Waldman HS (2020) Time-restricted feeding improves markers of cardiometabolic health in physically active college-age men: a 4-week randomized pre-post pilot study. Nutr Res 75:32–43
Jamshed H, Beyl RA, Della Manna DL et al (2019) Early time-restricted feeding improves 24-hour glucose levels and affects markers of the circadian clock, aging, and autophagy in humans. Nutrients 11:1234
Kirschbaum C, Bono EG, Rohleder N et al (1997) Effects of fasting and glucose load on free cortisol responses to stress and nicotine. J Clin Endocrinol Metab 82:1101–1105
Ishida A, Nakajima W, Takada G (1997) Short-term fasting alters neonatal rat striatal dopamine levels and serotonin metabolism: an in vivo microdialysis study. Dev Brain Res 104:131–136
Longo VD, Mattson MP (2014) Fasting: molecular mechanisms and clinical applications. Cell Metab 19:181–192
Zhang Y, Liu C, Zhao Y et al (2015) The effects of calorie restriction in depression and potential mechanisms. Curr Neuropharmacol 13:536–542
Huether G, Zhou D, Rüther E (1997) Long-term modulation of presynaptic 5-HT-output: experimentally induced changes in cortical 5-HT-transporter density, tryptophan hydroxylase content and 5-HT innervation density. J Neural Transm 104:993–1004
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Şentürk, E., Yıldız, M., Şentürk, M. et al. Investigation of the effect of Ramadan fasting on serum levels of melatonin, cortisol, and serotonin: the case of Turkey. Ir J Med Sci 193, 1073–1077 (2024). https://doi.org/10.1007/s11845-023-03532-1
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DOI: https://doi.org/10.1007/s11845-023-03532-1