Search
Search Results
-
Intrinsic disorder in PRAME and its role in uveal melanoma
IntroductionThe PReferentially expressed Antigen in MElanoma ( PRAME) protein has been shown to be an independent biomarker for increased risk of...
-
Enrichment patterns of intrinsic disorder in proteins
Intrinsically disordered regions in proteins have been shown to be important in protein function. However, not all proteins contain the same amount...
-
DisoFLAG: accurate prediction of protein intrinsic disorder and its functions using graph-based interaction protein language model
Intrinsically disordered proteins and regions (IDPs/IDRs) are functionally important proteins and regions that exist as highly dynamic conformations...
-
Tutorial: a guide for the selection of fast and accurate computational tools for the prediction of intrinsic disorder in proteins
Intrinsic disorder is instrumental for a wide range of protein functions, and its analysis, using computational predictions from primary structures,...
-
Intrinsic disorder in flaviviral capsid proteins and its role in pathogenesis
A high level of disorder in many viral proteins is a direct consequence of their small genomes, which makes interaction with multiple binding...
-
The pathogen-encoded signalling receptor Tir exploits host-like intrinsic disorder for infection
The translocated intimin receptor (Tir) is an essential type III secretion system (T3SS) effector of attaching and effacing pathogens contributing to...
-
Intrinsic disorder in proteins associated with oxidative stress-induced JNK signaling
The c-Jun N-terminal kinase (JNK) signaling cascade is a mitogen-activated protein kinase (MAPK) signaling pathway that can be activated in response...
-
Lighting up Nobel Prize-winning studies with protein intrinsic disorder
Intrinsically disordered proteins and regions (IDPs and IDRs) and their importance in biology are becoming increasingly recognized in biology,...
-
Critical assessment of protein intrinsic disorder prediction
Intrinsically disordered proteins, defying the traditional protein structure–function paradigm, are a challenge to study experimentally. Because a...
-
Relation between flexibility and intrinsically disorder regions in thermosensitive TRP channels reveal allosteric effects
How a protein propagates the conformational changes throughout its structure remains largely unknown. In thermosensitive TRP channels, this...
-
The protein disorder cycle
This mini-review represents a brief, disorder-centric consideration of the interplay between order and disorder in proteins. The goal here is to show...
-
Correction to: Budding yeast Rad51: a paradigm for how phosphorylation and intrinsic structural disorder regulate homologous recombination and protein homeostasis
The article: Budding yeast Rad51: a paradigm for how phosphorylation and intrinsic structural disorder regulate homologous recombination and protein...
-
Intrinsic disorder is an essential characteristic of components in the conserved circadian circuit
IntroductionThe circadian circuit, a roughly 24 h molecular feedback loop, or clock, is conserved from bacteria to animals and allows for enhanced...
-
IDPology of the living cell: intrinsic disorder in the subcellular compartments of the human cell
Intrinsic disorder can be found in all proteomes of all kingdoms of life and in viruses, being particularly prevalent in the eukaryotes. We conduct a...
-
Exploring Protein Intrinsic Disorder with MobiDB
Nowadays, it is well established that many proteins or regions under physiological conditions lack a fixed three-dimensional structure and are...
-
Disorder and amino acid composition in proteins: their potential role in the adaptation of extracellular pilins to the acidic media, where Acidithiobacillus thiooxidans grows
There are few biophysical studies or structural characterizations of the type IV pilin system of extremophile bacteria, such as the acidophilic Acidith...
-
Molecular determinants of intrinsic cellular stiffness in health and disease
In recent years, the role of intrinsic biophysical features, especially cellular stiffness, in diverse cellular and disease processes is being...
-
Budding yeast Rad51: a paradigm for how phosphorylation and intrinsic structural disorder regulate homologous recombination and protein homeostasis
The RecA-family recombinase Rad51 is the central player in homologous recombination (HR), the faithful pathway for repairing DNA double-strand breaks...
-
Multikingdom and functional gut microbiota markers for autism spectrum disorder
Associations between the gut microbiome and autism spectrum disorder (ASD) have been investigated although most studies have focused on the bacterial...
