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Using gene copy flexibility to build adaptable synthetic microbial populations
Plasmid coupling creates heterogeneity in copy number and, therefore, expression across a microbial population. We demonstrate that plasmid-encoded fitness differences between individuals can then lead to adaptation of the population to specific environments and can promote both genetic stability and memory of past environmental exposures.
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Multikingdom and functional gut microbiota markers for autism spectrum disorder
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Pan-drug resistance and hypervirulence in a human fungal pathogen are enabled by mutagenesis induced by mammalian body temperature
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MHC class II proteins mediate sialic acid independent entry of human and avian H2N2 influenza A viruses
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Gut microbial factors predict disease severity in a mouse model of multiple sclerosis