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Neurocytology: Cells of the CNS
There are two major cell types that form the nervous system: supporting cells and conducting cells. The supporting cells of the peripheral nervous...
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Mechanistic basis of MAGUK-organized complexes in synaptic development and signalling
Membrane-associated guanylate kinases (MAGUKs) are a family of scaffold proteins that are highly enriched in synapses and are responsible for...
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Psychiatric Conditions and Touch
Touch is an understudied sensory modality that has a significant neuroregulatory impact on social and emotional behavior relevant to psychiatric...
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Neuronal mechanisms and circuits underlying repetitive behaviors in mouse models of autism spectrum disorder
Autism spectrum disorder (ASD) refers to a broad spectrum of neurodevelopmental disorders characterized by three central behavioral symptoms:...
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Endocannabinoid-Dependent Synaptic Plasticity in the Striatum
The striatum plays a critical role in mediating the goal-directed and habitual behaviors involved in the development of drug abuse and addiction....
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Neurobiology of social behavior abnormalities in autism and Williams syndrome
Social behavior is a basic behavior mediated by multiple brain regions and neural circuits, and is crucial for the survival and development of...
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Future Directions for Animal Models in Behavior Genetics
The coming decades hold great promise and excitement for the field of behavioral genetics. Advances in sequencing technology have unraveled the...
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Reconstruction of the molecular interactome of glutamatergic synapses
The subunit composition of ionotropic glutamate receptors is of great significance for synapse functioning. NMDA receptors mediate fast excitatory...
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Posttranslational Modifications Regulate the Postsynaptic Localization of PSD-95
The postsynaptic density (PSD) consists of a lattice-like array of interacting proteins that organizes and stabilizes synaptic receptors, ion...
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The Postsynaptic Density
The postsynaptic density is a dense, submembranous filamentous structure beneath the postsynaptic membrane. It is a disklike structure that may or...
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Immune mediators in the brain and peripheral tissues in autism spectrum disorder
Increasing evidence points to a central role for immune dysregulation in autism spectrum disorder (ASD). Several ASD risk genes encode components of...
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Visualizing the Ultrastructures and Dynamics of Synapses by Single-Molecule Nanoscopy
Nanoscopic imaging techniques provide a powerful set of tools for static and dynamic fluorescence microscopy below the diffraction limit of light....
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GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling
How does chronic activity modulation lead to global remodeling of proteins at synapses and synaptic scaling? Here we report that guanylate...
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Proteostasis in complex dendrites
Like all cells, neurons are made of proteins that have characteristic synthesis and degradation profiles. Unlike other cells, however, neurons have a...
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Glutamatergic Postsynaptic Density Protein Dysfunctions in Synaptic Plasticity and Dendritic Spines Morphology: Relevance to Schizophrenia and Other Behavioral Disorders Pathophysiology, and Implications for Novel Therapeutic Approaches
Emerging researches point to a relevant role of postsynaptic density (PSD) proteins, such as PSD-95, Homer, Shank, and DISC-1, in the pathophysiology...
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The Postsynaptic Density
The postsynaptic density is a dense, submembranous filamentous structure beneath the postsynaptic membrane. It is a disklike structure that may or...
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Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 knockin mice
BackgroundPostsynaptic density (PSD)-95-like membrane-associated guanylate kinases (PSD-MAGUKs) are scaffold proteins in PSDs that cluster signaling...
