Abstract
The subunit composition of ionotropic glutamate receptors is of great significance for synapse functioning. NMDA receptors mediate fast excitatory neurotransmission and are capable of converting specific patterns of neuronal activity into long-term changes in synaptic structure and function. The principal functional properties (ion conductivity, glutamate sensitivity, agonists, and magnesium ions, and deactivation time), spatial location, membrane anchoring, and the response to pharmacological agents depend on subunit composition of the receptors. The analysis of protein–protein interactions in macrocomplexes, including NMDA receptor subunits, is an urgent task, because the results of research in this area will contribute to a better understanding of the principles and molecular mechanisms underlying the basic functions of neurons and the development of pathologies and facilitate the search for pharmacological and therapeutic targets for the correction of pathologies. The goal of the present work consisted of analyzing and reconstructing protein–protein interactions involving NMDA receptor subunits and providing for the mobility of NMDA receptors, the incorporation of these molecules into the membranes, and receptor functions related to modification and maintenance of synaptic transmission efficiency in the hippocampus. Three groups of proteins involved in the formation of NMDA receptor macrocomplexes in hippocampal glutamatergic synapses were identified. The proteins were divided into groups according to their function in the complexes; the functions were inferred from the information presented in various databases and research articles that reported gene and protein structures, expression profiles in the brain, and the role of specific genes and proteins in synaptic plasticity. Particular attention was paid to proteins for which a association with various cognitive disturbances was reported.
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Original Russian Text © A.L. Proskura, S.O. Vechkapova, T.A. Zapara, A.S. Ratushnyak, 2014, published in Vavilovskii Zhurnal Genetiki i Selektsii, 2014, Vol. 18, No. 4/3, pp. 1205–1218.
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Proskura, A.L., Vechkapova, S.O., Zapara, T.A. et al. Reconstruction of the molecular interactome of glutamatergic synapses. Russ J Genet Appl Res 5, 616–625 (2015). https://doi.org/10.1134/S2079059715060118
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DOI: https://doi.org/10.1134/S2079059715060118