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Drug Addiction and Drug Dependency
Drug abuse and dependency liability assessments are important components of the discovery, development, and evaluation of novel drug entities and are...
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Metagenomics for Drug Discovery
In the twenty-first century, approximately 100 years since the discovery and use of the first drug penicillin, antimicrobial resistance has become...
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Drug Resistance
There are concerns regarding the potential development of drug resistance in scabies. Recently, there has been a substantial increase in the global...
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Considerations Around Structure-Based Drug Discovery for KRAS Using DOCK
Molecular docking is a popular computational tool in drug discovery. Leveraging structural information, docking software predicts binding poses of...
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Role of Genomics and Proteomics in Drug Discovery
Genomics and proteomics are two powerful technologies that are revolutionizing the drug discovery process. Genomics is the study of the entire genome...
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Drug Delivery in Biotechnology: Present and Future
Nanobiotechnology is the integration of nanotechnology with biotechnology, with a specific emphasis on the utilisation of nanoscale techniques in...
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Biomaterials for Controlled Drug Delivery Applications
A drug delivery system (DDS) is by definition a platform that can transfer a therapeutic agent to the disease site in order to elicit and improve the...
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Acquisition of cocaine reinforcement using fixed-ratio and concurrent choice schedules in socially housed female and male monkeys
RationalePrevious studies in socially housed monkeys examining acquisition of cocaine self-administration under fixed-ratio (FR) schedules of...
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Mucoadhesive Films of Docetaxel with Ceramide as an Adjuvant Monitoring Polymer-Drug Partitioning for Optimal Drug Release
BackgroundMillions of individuals worldwide are affected by cancer, with increasing instances by 1% annually and strikingly high mortality rates of...
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How drug onset rate and duration of action affect drug forgiveness
Medication nonadherence is one of the largest problems in healthcare today, particularly for patients undergoing long-term pharmacotherapy. To combat...
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Drug Resistance in Hepatocellular Carcinoma
At present, the burden of cancer morbidity and mortality is increasing all over the world. Among all kinds of cancer, primary liver cancer is...
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Chemotherapy for Drug-Susceptible Tuberculosis
The decade of 1940s brought one of the major achievements when streptomycinStreptomycin was discovered to treat tuberculosis (TB)–the first effective...
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An economon model of drug addiction
The term “economon” (i:’ka.nə.muhn; plural: economa) is introduced here to describe an economic unit composed of two participants engaged in mutually...
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Piloting a forced-choice task to elicit treatment preferences in geographic atrophy
ObjectiveGeographic Atrophy (GA) is the advanced form of the non-neovascular (‘dry’) type of age-related macular degeneration (AMD) and responsible...
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Goal-Directed and Habitual Control in Human Drug Addiction
Learning theory has proposed that everyday actions are controlled by at least two dissociable systems: one that governs deliberate goal-directed...
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Accelerating Molecular Dynamics Simulations for Drug Discovery
Accurate prediction of ligand binding thermodynamics and kinetics is crucial in drug design. However, it remains challenging for conventional...
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Nanoemulsions as Drug Carriers to Combat AMR
Antimicrobial resistance (AMR) is an important health issue around the world. The substantial increase in AMR has severely restricted the existing...
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Impact of Apparatus and Adapter on In vitro Drug Release of Ophthalmic Semisolid Drug Products
PurposeIn vitro release testing (IVRT) is a widely used tool for evaluating the quality and performance of drug products. However, standardized...
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Drug Properties
Drug discoveryDrug discovery remains a complex and iterative process accompanied with a high failure rate. Before compounds enter the clinic,...
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Tumor Microenvironment-Responsive Nanoplatforms for Triggering Drug Delivery
Cancer is the second leading cause of mortality among nontransmissible diseases globally. Despite the advances in chemotherapy, the insufficient drug...
