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Genetic Testing in Reproductive Medicine

  • Textbook
  • © 2023

Overview

Editors:
  1. Rajender Singh

    1. Endocrinology Division, Central Drug Research Institute, Lucknow, India

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  • Covers genetic diagnosis for various reproductive disorders
  • Describes molecular approaches in the diagnosis of reproductive diseases
  • Presents ethical and legal aspects of genetic testing in reproductive medicine

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About this book

This textbook illustrates the importance and significance of molecular genetic testing in reproductive disorders. The present book covers the genetic testing in various reproductive system anomalies, including disorders of sexual development, male infertility (Y deletions, autosomal mutations, sperm DNA fragmentation), female infertility (PCOS and POF), mitochondrial DNA testing for oocyte quality, recurrent pregnancy loss, pre-term birth, endometrial receptivity, prenatal genetic screening, reproductive carrier screening, preimplantation genetic screening, endometrial cancer, cervical cancer and other related reproductive health disorders. Microbiome testing and its contribution to genetic testing in reproductive medicine are also discussed. Genetic testing in some of these has already come into practice, genetic testing for others is established but not clinically practiced, and genetic testing for others is yet in infancy as there is only limited data available. For the disorderswhere sufficient genetic data to undertake genetic testing is not available, we have tried to put together the evidence for proposing such tests in the near future. Apart from this, the book also covers ethical, moral and technical challenges in genetic testing in reproductive medicine. The book aims to set up a standard with regard to genetic testing in the reproductive medicine field, encourage further data generation, and provide food for thought in the areas of lacunae. The book serves graduate students, researchers, clinicians, professors, and patients in the field of reproductive medicine.​

Keywords

Table of contents (20 chapters)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. Genetic Testing in Disorders of Sexual Development

    • Vertika Singh, Ankur Saharan, David Handelsman, Rajender Singh
    Pages 1-16

  3. Y-Chromosome Deletion Testing in Infertility

    • Shruti Sethi, Rajender Singh
    Pages 17-29

  4. Genetic Testing in Male Infertility

    • Shruti Sethi, Rajender Singh
    Pages 31-46

  5. Sperm DNA Fragmentation Testing in Infertility

    • Pallav Sengupta, Sulagna Dutta, Antony V. Samrot
    Pages 47-66

  6. Microbiome Testing in Male Infertility

    • George Anifandis, Christina I. Messini, Katerina Chatzimeletiou, Alexandros Daponte, Ioannis E. Messinis
    Pages 67-79

  7. Genetic Testing in Polycystic Ovary Syndrome

    • Ankur Saharan, Vertika Singh, Rajender Singh
    Pages 81-103

  8. Genetic Testing in Premature Ovarian Failure

    • Anam Ara, Poonam Mehta, Rajender Singh
    Pages 105-132

  9. Microbiome Testing in Female Infertility

    • Anshita Sharma, Rajender Singh
    Pages 133-144

  10. Preimplantation Genetic Testing

    • Sarabpreet Singh, Fiona Olvitta D’Souza
    Pages 145-161

  11. Mitochondrial DNA Testing in Assisted Reproduction

    • Kajal Khodamoradi, Alexandra Dullea, Yaima C. Valdes, Zahra Khosravizadeh, Isabelle Catherine Issa, Ineabelle Collazo et al.
    Pages 163-183

  12. Genetic Testing for Endometrial Receptivity

    • Anshita Sharma, Rajender Singh
    Pages 185-196

  13. Prenatal Genetic Testing

    • Fiona Olvitta D’Souza, Sarabpreet Singh
    Pages 197-210

  14. Genetic Testing in Recurrent Pregnancy Loss

    • Priyanka Verma
    Pages 211-221

  15. Genetic Testing in Pregnancy to Assess the Risk of Preterm Birth

    • Renu Bala, Rajender Singh
    Pages 223-234

  16. Reproductive Carrier Screening

    • Anam Ara, Poonam Mehta, Rajender Singh
    Pages 235-250

  17. Genetic Testing in Endometrial Cancer

    • Vertika Singh, Anshita Sharma, Rajender Singh
    Pages 251-264

  18. Genetic Testing in Cervical Cancer

    • Anshita Sharma, Rajender Singh
    Pages 265-278

  19. Ethical Solicitude in Reproductive Carrier Screening

    • Anam Ara, Poonam Mehta, Rajender Singh
    Pages 279-289

  20. Genetic Counseling in Reproductive Medicine

    • Sarabpreet Singh, B. Suruthi Abirami, Fiona Olvitta D’Souza, Rajni Khajuria
    Pages 291-308
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Editors and Affiliations

  • Endocrinology Division, Central Drug Research Institute, Lucknow, India

    Rajender Singh

About the editor

Dr. Rajender Singh is a Senior Principal Scientist and Professor of Biology at the Central Drug Research Institute (CDRI), Lucknow, India. He has been working as a scientist in this institute for the last 16 years. His research interests lie in genetics and genomics of male reproduction and infertility with specific emphasis on sperm RNAs and epigenome. Dr. Singh has published more than 150 research articles, 36 book chapters and 3 books in the area of reproductive biology. Dr. Singh is serving as an associate editor for Reproductive Biology and Endocrinology, Reproductive Health and Andrologia journals, and as Andrology Specialty Chief Editor for Frontiers in Reproductive Health journal. His work has been recognized by a number of prestigious scientific bodies in the form of Haryana Yuva Vigyan Ratna Award (2018), the INDO US Post-doctoral Research Fellowship at the University of Alabama at Birmingham (2017), the Innovative Young Biotechnologist Award from the Department of Biotechnology (2015), the Young Scientist Award from the Council of Scientific and Industrial Research (2014), the Young Scientist Award from the Indian Science Congress Association (2012), the Young Scientist Award from the Indian National Scientific Academy (2011) and the Young Scientist Award from the Indian Society of Human Genetics (2006). He is a member of the Indian Society for the study of Reproduction and Fertility (ISSRF), Indian Fertility Society (IFS), the Indian Society of Human Genetics (ISHG). ​

Bibliographic Information

  • Book Title: Genetic Testing in Reproductive Medicine

  • Editors: Rajender Singh

  • DOI: https://doi.org/10.1007/978-981-99-7028-5

  • Publisher: Springer Singapore

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2023

  • Hardcover ISBN: 978-981-99-7027-8Published: 01 March 2024

  • Softcover ISBN: 978-981-99-7030-8Due: 15 April 2024

  • eBook ISBN: 978-981-99-7028-5Published: 29 February 2024

  • Edition Number: 1

  • Number of Pages: XIII, 317

  • Number of Illustrations: 1 b/w illustrations

  • Topics: Genetics and Genomics, Reproductive Medicine, Human Genetics, Human Genetics

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